DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp83 and HSP81-2

DIOPT Version :9

Sequence 1:	NP_001261362.1	Gene:	Hsp83 / 38389	FlyBaseID:	FBgn0001233	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001190553.1	Gene:	HSP81-2 / 835701	AraportID:	AT5G56030	Length:	728	Species:	Arabidopsis thaliana

Alignment Length:	745	Identity:	480/745 - (64%)
Similarity:	592/745 - (79%)	Gaps:	50/745 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EAETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASD-------------------------- 42
            :||||||||||.||:|||||||||||||||||||||:||
plant     3 DAETFAFQAEINQLLSLIINTFYSNKEIFLRELISNSSDVRSLSLSTLLYTCVSRLIDLADGSVD 67

  Fly    43 ---ALDKIRYESLTDPSKLDSGKELYIKLIPNKTAGTLTIIDTGIGMTKSDLVNNLGTIAKSGTK 104
               ||||||:|||||.||||...||:|.:||:||..||||||:||||||:||||||||||:||||
plant    68 LGLALDKIRFESLTDKSKLDGQPELFIHIIPDKTNNTLTIIDSGIGMTKADLVNNLGTIARSGTK 132

  Fly   105 AFMEALQAGADISMIGQFGVGFYSAYLVADKVTVTSKNNDDEQYVWESSAGGSFTVRADNS-EPL 168
            .|||||.||||:||||||||||||||||||||.||:|:||||||||||.|||||||..|.| |.|
plant   133 EFMEALAAGADVSMIGQFGVGFYSAYLVADKVVVTTKHNDDEQYVWESQAGGSFTVTRDTSGETL 197

  Fly   169 GRGTKIVLYIKEDQTDYLEESKIKEIVNKHSQFIGYPIKLLVEKEREKEVSDDEADDEKKEGDEK 233
            |||||:|||:||||.:||||.::|::|.|||:||.|||.|.:||..|||:||||.::|||:
plant   198 GRGTKMVLYLKEDQLEYLEERRLKDLVKKHSEFISYPISLWIEKTIEKEISDDEEEEEKKD---- 258

  Fly   234 KEMETDEPKIEDVGEDEDADKKDKDAKKKKTIKEKYTEDEELNKTKPIWTRNPDDISQEEYGEFY 298
                 :|.|:|:|.|:     |:|:.||||.|||...|.:.:||.||||.|.|::|::|||..||
plant   259 -----EEGKVEEVDEE-----KEKEEKKKKKIKEVSHEWDLVNKQKPIWMRKPEEINKEEYAAFY 313

  Fly   299 KSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRTPFDLFENQKKRNNIKLYVRRVFIMDNCEDLI 363
            |||:||||:|||||||||||||||:|:||:|:|.|||||:.:||.||||||||||||||||||:|
plant   314 KSLSNDWEEHLAVKHFSVEGQLEFKAILFVPKRAPFDLFDTKKKPNNIKLYVRRVFIMDNCEDII 378

  Fly   364 PEYLNFMKGVVDSEDLPLNISREMLQQNKVLKVIRKNLVKKTMELIEELTEDKENYKKFYDQFSK 428
            ||||.|:||:|||||||||||||.|||||:|||||||||||.:||..|:.|:||:|.|||:.|||
plant   379 PEYLGFVKGIVDSEDLPLNISRETLQQNKILKVIRKNLVKKCLELFFEIAENKEDYNKFYEAFSK 443

  Fly   429 NLKLGVHEDSNNRAKLADFLRFHTSASGDDFCSLADYVSRMKDNQKHVYFITGESKDQVSNSAFV 493
            |||||:||||.||.|:|:.||:|::.|||:..||.|||:|||:.|..:::||||||..|.||.|:
plant   444 NLKLGIHEDSQNRTKIAELLRYHSTKSGDELTSLKDYVTRMKEGQNDIFYITGESKKAVENSPFL 508

  Fly   494 ERVKARGFEVVYMTEPIDEYVIQHLKEYKGKQLVSVTKEGLELPEDESEKKKREEDKAKFESLCK 558
            |::|.:|.||:||.:.||||.|..|||::||:|||.|||||:|.|.|.||||:||.|.|||.|||
plant   509 EKLKKKGIEVLYMVDAIDEYAIGQLKEFEGKKLVSATKEGLKLDETEDEKKKKEELKEKFEGLCK 573

  Fly   559 LMKSILDNKVEKVVVSNRLVDSPCCIVTSQFGWSANMERIMKAQALRDTATMGYMAGKKQLEINP 623
            ::|.:|.:|||||:||:|:||||||:||.::||:||||||||||||||::..|||:.||.:||||
plant   574 VIKDVLGDKVEKVIVSDRVVDSPCCLVTGEYGWTANMERIMKAQALRDSSMAGYMSSKKTMEINP 638

  Fly   624 DHPIVETLRQKADADKNDKAVKDLVILLFETSLLSSGFSLDSPQVHASRIYRMIKLGLGIDEDEP 688
            ::.|::.||::||||||||:|||||:|||||:||:||||||.|....|||:||:||||.||:|:.
plant   639 ENSIMDELRKRADADKNDKSVKDLVLLLFETALLTSGFSLDEPNTFGSRIHRMLKLGLSIDDDDA 703

  Fly   689 MTTDDAQSAGDAPSLVEDTE-DASHMEEVD 717
            :..|     .:.|.|.:|.: :.|.|||||
plant   704 VEAD-----AEMPPLEDDADAEGSKMEEVD 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp83	NP_001261362.1	PTZ00272	6..717	CDD:240341	477/741 (64%)
		HATPase_c	28..179	CDD:214643	123/180 (68%)
		HSP90	184..706	CDD:278607	325/521 (62%)
HSP81-2	NP_001190553.1	PTZ00272	5..728	CDD:240341	477/741 (64%)
		HATPase_c	<94..210	CDD:280651	93/115 (81%)
		HSP90	213..728	CDD:278607	330/533 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	681	1.000	Domainoid score	I18
eggNOG	1	0.900	-	-		E1_COG0326
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	978	1.000	Inparanoid score	I47
OMA	1	1.010	-	-		QHG62690
OrthoDB	1	1.010	-	-		D924636at2759
OrthoFinder	1	1.000	-	-		FOG0000295
OrthoInspector	1	1.000	-	-		otm2837
orthoMCL	1	0.900	-	-		OOG6_100204
Panther	1	1.100	-	-	O	PTHR11528
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X234
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840