DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp83 and SHD

DIOPT Version :9

Sequence 1:	NP_001261362.1	Gene:	Hsp83 / 38389	FlyBaseID:	FBgn0001233	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_194150.1	Gene:	SHD / 828520	AraportID:	AT4G24190	Length:	823	Species:	Arabidopsis thaliana

Alignment Length:	741	Identity:	354/741 - (47%)
Similarity:	500/741 - (67%)	Gaps:	52/741 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 AETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGK----ELY 65
            ||.|.||||:::||.:|||:.||||:||||||||||||||||||:.:|||...|..|.    |:.
plant    76 AEKFEFQAEVSRLMDIIINSLYSNKDIFLRELISNASDALDKIRFLALTDKDVLGEGDTAKLEIQ 140

  Fly    66 IKLIPNKTAGTLTIIDTGIGMTKSDLVNNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAY 130
            |||  :|....|:|.|.||||||.||:.||||||||||.||:|.:|:..|:::||||||||||||
plant   141 IKL--DKAKKILSIRDRGIGMTKEDLIKNLGTIAKSGTSAFVEKMQSSGDLNLIGQFGVGFYSAY 203

  Fly   131 LVADKVTVTSKNNDDEQYVWESSAGGSFTVRADN-SEPLGRGTKIVLYIKEDQTDYLEESKIKEI 194
            ||||.:.|.||:|||.||||||.|.|.|.|..|. :|||||||:|.|:::::..:||||||:||:
plant   204 LVADYIEVISKHNDDSQYVWESKANGKFAVSEDTWNEPLGRGTEIRLHLRDEAGEYLEESKLKEL 268

  Fly   195 VNKHSQFIGYPIKLLVEKEREKE--VSDDEADDEKKEGDEKKEMETDEPKIEDVGEDEDADKKDK 257
            |.::|:||.:||.|...||.|.|  |.:||:.||     |.:...|:|.|.|| .|:||.:||.|
plant   269 VKRYSEFINFPISLWASKEVETEVPVEEDESADE-----ETETTSTEEEKEED-AEEEDGEKKQK 327

  Fly   258 DAKKKKTIKEKYTEDEELNKTKPIWTRNPDDISQEEYGEFYKSLTNDWEDH--LAVKHFSVEGQL 320
            ..|.|:|:.|.    |.||..|.||.|:|.::::|||.:||.||:.|:.|.  :|..||:.||.:
plant   328 TKKVKETVYEW----ELLNDVKAIWLRSPKEVTEEEYTKFYHSLSKDFTDEKPMAWSHFNAEGDV 388

  Fly   321 EFRALLFIPRRTPFDLFENQKKRN--NIKLYVRRVFIMDNCEDLIPEYLNFMKGVVDSEDLPLNI 383
            ||:|:|::|.:.|.||:|:....|  |:|||||||||.|..::|:|:||:|:||:|||:.||||:
plant   389 EFKAVLYVPPKAPHDLYESYYNSNKANLKLYVRRVFISDEFDELLPKYLSFLKGLVDSDTLPLNV 453

  Fly   384 SREMLQQNKVLKVIRKNLVKKTMELIEELTED----------------------KENYKKFYDQF 426
            |||||||:..||.|:|.|::|.:::|.:|.|:                      |..|.||:::|
plant   454 SREMLQQHSSLKTIKKKLIRKALDMIRKLAEEDPDEIHDDEKKDVEKSGENDEKKGQYTKFWNEF 518

  Fly   427 SKNLKLGVHEDSNNRAKLADFLRFHTSASGDDFCSLADYVSRMKDNQKHVYFITGESKDQVSNSA 491
            .|::|||:.||:.||.:||..|||.|:.|.....||..|:.|||.:||.:::|||.||:|:..|.
plant   519 GKSVKLGIIEDAANRNRLAKLLRFETTKSDGKLTSLDQYIKRMKKSQKDIFYITGSSKEQLEKSP 583

  Fly   492 FVERVKARGFEVVYMTEPIDEYVIQHLKEYKGKQLVSVTKEGLELPEDESEKKKREEDKAKFESL 556
            |:||:..:|:||::.|:|:|||::|:|.:|:.|:..:|:||||::.:|..:|:.:|    .|:.|
plant   584 FLERLIKKGYEVIFFTDPVDEYLMQYLMDYEDKKFQNVSKEGLKVGKDSKDKELKE----AFKEL 644

  Fly   557 CKLMK-SILDNKVEKVVVSNRLVDSPCCIVTSQFGWSANMERIMKAQALRDTATMGYMAGKKQLE 620
            .|..| ::....|:.|.:||||.|:||.:|||:|||||||||||::|.|.|.....||.||:.||
plant   645 TKWWKGNLASENVDDVKISNRLADTPCVVVTSKFGWSANMERIMQSQTLSDANKQAYMRGKRVLE 709

  Fly   621 INPDHPIVETLRQKADADKNDKAVKDLVILLFETSLLSSGFSLDSPQVHASRIYRMIKLGLGIDE 685
            |||.|||::.|:.:..:|..|::||:...|:::|:|:.|||.|..|:..|:|||..:|.||.|..
plant   710 INPRHPIIKELKDRIASDPEDESVKETAQLMYQTALIESGFILTDPKDFAARIYNSVKSGLNISP 774

  Fly   686 DEPMTTDDAQSAGDAPSLVEDTEDAS 711
            |  ...|:...|.:.|...|.||..|
plant   775 D--AVADEEIEAAEEPETSEATETKS 798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp83	NP_001261362.1	PTZ00272	6..717	CDD:240341	353/740 (48%)
		HATPase_c	28..179	CDD:214643	98/155 (63%)
		HSP90	184..706	CDD:278607	238/550 (43%)
SHD	NP_194150.1	PRK05218	74..763	CDD:235366	340/702 (48%)
		HATPase_c	104..253	CDD:280651	94/150 (63%)
		HSP90	258..775	CDD:278607	234/530 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0326
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D924636at2759
OrthoFinder	1	1.000	-	-		FOG0000295
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100204
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X234
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.720