DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp83 and hsp90aa1.2

DIOPT Version :9

Sequence 1:	NP_001261362.1	Gene:	Hsp83 / 38389	FlyBaseID:	FBgn0001233	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001038538.1	Gene:	hsp90aa1.2 / 565155	ZFINID:	ZDB-GENE-031001-3	Length:	734	Species:	Danio rerio

Alignment Length:	724	Identity:	564/724 - (77%)
Similarity:	644/724 - (88%)	Gaps:	11/724 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EEAETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELYIK 67
            ||.||||||||||||||||||||||||||||||||||:||||||||||||||||||||||:|.|:
Zfish    13 EEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKDLKIE 77

  Fly    68 LIPNKTAGTLTIIDTGIGMTKSDLVNNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLV 132
            :||||...|||||||||||||:||:||||||||||||||||||||||||||||||||||||||||
Zfish    78 IIPNKEERTLTIIDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLV 142

  Fly   133 ADKVTVTSKNNDDEQYVWESSAGGSFTVRADNSEPLGRGTKIVLYIKEDQTDYLEESKIKEIVNK 197
            |:||||.:|:.|||||.|||||||||||:.|||||:|||||::|::|||||:|:||.:|||||.|
Zfish   143 AEKVTVITKHLDDEQYAWESSAGGSFTVKVDNSEPIGRGTKVILHLKEDQTEYIEERRIKEIVKK 207

  Fly   198 HSQFIGYPIKLLVEKEREKEVSDDEADDEK---KEGDEKKEMETDEPKIEDVGEDED----ADKK 255
            |||||||||.|.|||||:||||||||::||   ||.:|:.|.:.|:|:|||||.|||    .||.
Zfish   208 HSQFIGYPITLFVEKERDKEVSDDEAEEEKEKEKEEEEEGEKDEDKPEIEDVGSDEDDHDHGDKC 272

  Fly   256 DKDAKKKKTIKEKYTEDEELNKTKPIWTRNPDDISQEEYGEFYKSLTNDWEDHLAVKHFSVEGQL 320
            ....||||.|||||.:.||||||||:||||||||:.|||||||||||||||||||||||||||||
Zfish   273 GDKKKKKKKIKEKYIDQEELNKTKPLWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQL 337

  Fly   321 EFRALLFIPRRTPFDLFENQKKRNNIKLYVRRVFIMDNCEDLIPEYLNFMKGVVDSEDLPLNISR 385
            |||||||:|||.|||||||:||:||||||||||||||||::||||||||:|||||||||||||||
Zfish   338 EFRALLFVPRRAPFDLFENKKKKNNIKLYVRRVFIMDNCDELIPEYLNFIKGVVDSEDLPLNISR 402

  Fly   386 EMLQQNKVLKVIRKNLVKKTMELIEELTEDKENYKKFYDQFSKNLKLGVHEDSNNRAKLADFLRF 450
            |||||:|:|||||||||||.:||..||.|||:||||:|:|||||:|||:||||.||.||::.||:
Zfish   403 EMLQQSKILKVIRKNLVKKCLELFTELAEDKDNYKKYYEQFSKNIKLGIHEDSQNRKKLSELLRY 467

  Fly   451 HTSASGDDFCSLADYVSRMKDNQKHVYFITGESKDQVSNSAFVERVKARGFEVVYMTEPIDEYVI 515
            :||||||:..||.|||:||||.|||:|:||||:||||:|||||||::..|.||:||.||||||.:
Zfish   468 YTSASGDEMVSLKDYVTRMKDTQKHIYYITGETKDQVANSAFVERLRKAGLEVIYMIEPIDEYCV 532

  Fly   516 QHLKEYKGKQLVSVTKEGLELPEDESEKKKREEDKAKFESLCKLMKSILDNKVEKVVVSNRLVDS 580
            |.|||::||.|||||||||||||||.||||:||.|:|||:|||:||.||:.|||||.||||||.|
Zfish   533 QQLKEFEGKNLVSVTKEGLELPEDEEEKKKQEEKKSKFENLCKIMKDILEKKVEKVTVSNRLVSS 597

  Fly   581 PCCIVTSQFGWSANMERIMKAQALRDTATMGYMAGKKQLEINPDHPIVETLRQKADADKNDKAVK 645
            |||||||.:||:||||||||||||||.:||||||.||.|||||||||||||||||:||||||:||
Zfish   598 PCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHPIVETLRQKAEADKNDKSVK 662

  Fly   646 DLVILLFETSLLSSGFSLDSPQVHASRIYRMIKLGLGIDEDEPMTTDDAQSA--GDAPSLVEDTE 708
            |||||||||:||||||:||.||.|::|||||||||||||||: ::.::..||  .:.|.| |..:
Zfish   663 DLVILLFETALLSSGFTLDDPQTHSNRIYRMIKLGLGIDEDD-LSAEEPSSAPIEEMPPL-EGDD 725

  Fly   709 DASHMEEVD 717
            |.|.|||||
Zfish   726 DTSRMEEVD 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp83	NP_001261362.1	PTZ00272	6..717	CDD:240341	560/719 (78%)
		HATPase_c	28..179	CDD:214643	128/150 (85%)
		HSP90	184..706	CDD:278607	399/530 (75%)
hsp90aa1.2	NP_001038538.1	PTZ00272	16..734	CDD:240341	560/719 (78%)
		HATPase_c	38..189	CDD:214643	128/150 (85%)
		HSP90	194..724	CDD:278607	400/531 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580776
Domainoid	1	1.000	834	1.000	Domainoid score	I64
eggNOG	1	0.900	-	-		E1_COG0326
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1156	1.000	Inparanoid score	I199
OMA	1	1.010	-	-		QHG62690
OrthoDB	1	1.010	-	-		D174605at33208
OrthoFinder	1	1.000	-	-		FOG0000295
OrthoInspector	1	1.000	-	-		otm25280
orthoMCL	1	0.900	-	-		OOG6_100204
Panther	1	1.100	-	-	O	PTHR11528
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R576
SonicParanoid	1	1.000	-	-		X234
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800