DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp83 and hsp90b1

DIOPT Version :9

Sequence 1:	NP_001261362.1	Gene:	Hsp83 / 38389	FlyBaseID:	FBgn0001233	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_937853.1	Gene:	hsp90b1 / 386590	ZFINID:	ZDB-GENE-031002-1	Length:	793	Species:	Danio rerio

Alignment Length:	731	Identity:	344/731 - (47%)
Similarity:	480/731 - (65%)	Gaps:	42/731 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EEAETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELYIK 67
            ::||..|||||:.::|.||||:.|.|||||||||||||||||||||..|||:...|...:||.||
Zfish    71 DKAEKHAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLLSLTNEDALAGNEELTIK 135

  Fly    68 LIPNKTAGTLTIIDTGIGMTKSDLVNNLGTIAKSGTKAFMEALQAGADIS-----MIGQFGVGFY 127
            :..:|....|.|.||||||||.:||.||||||||||..|:..:....|.|     :|||||||||
Zfish   136 IKSDKEKNMLHITDTGIGMTKEELVKNLGTIAKSGTSEFLNKMTEVQDDSQSTSELIGQFGVGFY 200

  Fly   128 SAYLVADKVTVTSKNNDDEQYVWESSAGGSFTVRADNSEPLGRGTKIVLYIKEDQTDYLEESKIK 192
            ||:||||||.||||:|:|.|::|||.:.....:.....:.|||||.|.|.:||:.:||||...||
Zfish   201 SAFLVADKVIVTSKHNNDTQHMWESDSNQFSVIEDPRGDTLGRGTTITLVMKEEASDYLELETIK 265

  Fly   193 EIVNKHSQFIGYPIKLLVEK-EREKEVSDDEADDEKKEGDEKKEMETDEPKIEDVGEDEDADKKD 256
            .:|.|:||||.:||.:...| |..:|..:|||:.||:|..|      ||.::|:       :::|
Zfish   266 NLVKKYSQFINFPIYVWSSKTETVEEPIEDEAEAEKEEATE------DEAEVEE-------EEED 317

  Fly   257 KDAKKKKTIKEKYTEDEELNKTKPIWTRNPDDISQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLE 321
            ||..|.|.:::...:.|.:|..||||.|...::.::||..|||:.:.|.::.|:..||:.||::.
Zfish   318 KDKPKTKKVEKTVWDWELMNDIKPIWQRPAKEVEEDEYTAFYKTFSRDTDEPLSHIHFTAEGEVT 382

  Fly   322 FRALLFIPRRTPFDLFE--NQKKRNNIKLYVRRVFIMDNCEDLIPEYLNFMKGVVDSEDLPLNIS 384
            |:::||:|...|..||:  ..||.:.|||:||||||.|:..|::|:||||:||||||:|||||:|
Zfish   383 FKSILFVPASAPRGLFDEYGTKKNDFIKLFVRRVFITDDFHDMMPKYLNFIKGVVDSDDLPLNVS 447

  Fly   385 REMLQQNKVLKVIRKNLVKKTMELIEELTEDKENYKKFYDQFSKNLKLGVHEDSNNRAKLADFLR 449
            ||.|||:|:||||||.||:||:::|:::.|::.| .||:.:|..|:||||.||.:||.:||..||
Zfish   448 RETLQQHKLLKVIRKKLVRKTLDMIKKIAEEQYN-DKFWKEFGTNIKLGVIEDHSNRTRLAKLLR 511

  Fly   450 FHTSASGDDFCSLADYVSRMKDNQKHVYFITGESKDQVSNSAFVERVKARGFEVVYMTEPIDEYV 514
            |.||.|.....||..||.|||:.|..:||:.|.|:.:..:|.|||::..:|:||||:|||:|||.
Zfish   512 FQTSHSDTVLSSLEQYVERMKEKQDKIYFMAGTSRKEAESSPFVEKLLKKGYEVVYLTEPVDEYC 576

  Fly   515 IQHLKEYKGKQLVSVTKEGLELPEDESEKKKREEDKAKFESLCKLMK-SILDNKVEKVVVSNRLV 578
            ||.|.|:.||:..:|.|||::..|.:..|:|||..:.:||.|...|| ..|..::||.|:|.||.
Zfish   577 IQALPEFDGKRFQNVAKEGVKFDESDKAKEKREALEKEFEPLTTWMKDKALKEQIEKAVLSQRLT 641

  Fly   579 DSPCCIVTSQFGWSANMERIMKAQAL---RDTATMGYMAGKKQLEINPDHPIVETLRQKADADKN 640
            :|||.:|.||:|||.||||||||||.   :|.:|..|.:.||.|||||.||:::.:.::.:.|..
Zfish   642 NSPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTLEINPKHPLIKEMLRRVNEDAE 706

  Fly   641 DKAVKDLVILLFETSLLSSGFSLDSPQVHASRIYRMIKLGLGID-----EDEPMTTDDAQSAGDA 700
            ||...||.::||||:.|.||:.|...:.:..||.||::|.:.:|     |:||....:
Zfish   707 DKTAADLAVVLFETATLRSGYQLQDTKAYGERIERMLRLSMNVDLDAQVEEEPEEEPE------- 764

  Fly   701 PSLVEDTEDASHMEEV 716
                |.||:|...|||
Zfish   765 ----EQTEEAEDEEEV 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp83	NP_001261362.1	PTZ00272	6..717	CDD:240341	343/728 (47%)
		HATPase_c	28..179	CDD:214643	89/155 (57%)
		HSP90	184..706	CDD:278607	233/533 (44%)
hsp90b1	NP_937853.1	PRK05218	74..746	CDD:235366	331/685 (48%)
		HATPase_c	98..216	CDD:238030	74/117 (63%)
		HSP90	257..755	CDD:278607	230/511 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0326
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D174605at33208
OrthoFinder	1	1.000	-	-		FOG0000295
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100204
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X234
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.720