DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp83 and Hsp90b1

DIOPT Version :9

Sequence 1:	NP_001261362.1	Gene:	Hsp83 / 38389	FlyBaseID:	FBgn0001233	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001012197.2	Gene:	Hsp90b1 / 362862	RGDID:	1310482	Length:	804	Species:	Rattus norvegicus

Alignment Length:	728	Identity:	349/728 - (47%)
Similarity:	484/728 - (66%)	Gaps:	35/728 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EEAETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELYIK 67
            |::|.||||||:.::|.||||:.|.|||||||||||||||||||||..||||.:.|...:||.:|
  Rat    71 EKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALAGNEELTVK 135

  Fly    68 LIPNKTAGTLTIIDTGIGMTKSDLVNNLGTIAKSGTKAFM----EALQAGADIS-MIGQFGVGFY 127
            :..::....|.:.|||:|||:.:||.||||||||||..|:    ||.:.|...| :|||||||||
  Rat   136 IKCDREKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFY 200

  Fly   128 SAYLVADKVTVTSKNNDDEQYVWESSAGGSFTVRAD-NSEPLGRGTKIVLYIKEDQTDYLEESKI 191
            ||:||||||.||||:|:|.|::|||.: ..|:|.|| ....|||||.|.|.:||:.:||||...|
  Rat   201 SAFLVADKVIVTSKHNNDTQHIWESDS-NEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTI 264

  Fly   192 KEIVNKHSQFIGYPIKLLVEKER--EKEVSDDE-ADDEKKEGDEKKEMETDEPKIEDVGEDEDAD 253
            |.:|.|:||||.:||.:...|..  |:.:.:|| |.:||:|.|       ||..:    |:|:.:
  Rat   265 KNLVRKYSQFINFPIYVWSSKTETVEEPLEEDETAQEEKEEAD-------DEAAV----EEEEEE 318

  Fly   254 KKDKDAKKKKTIKEKYTEDEELNKTKPIWTRNPDDISQEEYGEFYKSLTNDWEDHLAVKHFSVEG 318
            ||.|..|.:||:    .:.|.:|..||||.|...::.::||..||||.:.:.:|.:|..||:.||
  Rat   319 KKPKTKKVEKTV----WDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEG 379

  Fly   319 QLEFRALLFIPRRTPFDLFE--NQKKRNNIKLYVRRVFIMDNCEDLIPEYLNFMKGVVDSEDLPL 381
            ::.|:::||:|...|..||:  ..||.:.||||||||||.|:..|::|:||||:||||||:||||
  Rat   380 EVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPL 444

  Fly   382 NISREMLQQNKVLKVIRKNLVKKTMELIEELTEDKENYKKFYDQFSKNLKLGVHEDSNNRAKLAD 446
            |:|||.|||:|:||||||.||:||:::|:::.::|.| ..|:.:|..|:||||.||.:||.:||.
  Rat   445 NVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADEKYN-DTFWKEFGTNIKLGVIEDHSNRTRLAK 508

  Fly   447 FLRFHTSASGDDFCSLADYVSRMKDNQKHVYFITGESKDQVSNSAFVERVKARGFEVVYMTEPID 511
            .|||.:|....|..||..||.|||:.|..:||:.|.|:.:..:|.||||:..:|:||:|:|||:|
  Rat   509 LLRFQSSHHSTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVD 573

  Fly   512 EYVIQHLKEYKGKQLVSVTKEGLELPEDESEKKKREEDKAKFESLCKLMK-SILDNKVEKVVVSN 575
            ||.||.|.|:.||:..:|.|||::..|.|..|:.||..:.:||.|...|| ..|.:|:||.|||.
  Rat   574 EYCIQALPEFDGKRFQNVAKEGVKFDESEKSKESREATEKEFEPLLNWMKDKALKDKIEKAVVSQ 638

  Fly   576 RLVDSPCCIVTSQFGWSANMERIMKAQAL---RDTATMGYMAGKKQLEINPDHPIVETLRQKADA 637
            ||.:|||.:|.||:|||.||||||||||.   :|.:|..|.:.||..||||.||::..:.::...
  Rat   639 RLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRVKE 703

  Fly   638 DKNDKAVKDLVILLFETSLLSSGFSLDSPQVHASRIYRMIKLGLGIDEDEPMTTDDAQSAGDAPS 702
            |::||.|.||.::||||:.|.||:.|...:.:..||.||::|.|.||.:..:..:..:...|.
  Rat   704 DEDDKTVMDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPEAQVEEEPEEEPEDT-- 766

  Fly   703 LVEDTEDASHMEE 715
             .|||.|.|..:|
  Rat   767 -TEDTTDDSEQDE 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp83	NP_001261362.1	PTZ00272	6..717	CDD:240341	348/725 (48%)
		HATPase_c	28..179	CDD:214643	91/156 (58%)
		HSP90	184..706	CDD:278607	236/530 (45%)
Hsp90b1	NP_001012197.2	HATPase_Hsp90-like	83..275	CDD:340404	109/192 (57%)
		HSP90	257..755	CDD:395131	235/513 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	288..323		14/45 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	749..804		9/33 (27%)
		Prevents secretion from ER. /evidence=ECO:0000255	801..804
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0326
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D174605at33208
OrthoFinder	1	1.000	-	-		FOG0000295
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100204
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X234
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.720