DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp83 and hsp90aa1.1

DIOPT Version :9

Sequence 1:	NP_001261362.1	Gene:	Hsp83 / 38389	FlyBaseID:	FBgn0001233	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_571403.1	Gene:	hsp90aa1.1 / 30591	ZFINID:	ZDB-GENE-990415-94	Length:	726	Species:	Danio rerio

Alignment Length:	719	Identity:	543/719 - (75%)
Similarity:	633/719 - (88%)	Gaps:	9/719 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EEAETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELYIK 67
            ||.||||||||||||||||||||||||||||||||||:||||||||||||||||||||.|:|.|:
Zfish    13 EEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSCKDLKIE 77

  Fly    68 LIPNKTAGTLTIIDTGIGMTKSDLVNNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLV 132
            |||::...|||||||||||||:||:||||||||||||||||||||||||||||||||||||||||
Zfish    78 LIPDQKERTLTIIDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLV 142

  Fly   133 ADKVTVTSKNNDDEQYVWESSAGGSFTVRADNSEPLGRGTKIVLYIKEDQTDYLEESKIKEIVNK 197
            |:||||.:|:||||||:|||:|||||||:.|..|.:|||||::|::||||::|:||.:|||:|.|
Zfish   143 AEKVTVITKHNDDEQYIWESAAGGSFTVKPDFGESIGRGTKVILHLKEDQSEYVEEKRIKEVVKK 207

  Fly   198 HSQFIGYPIKLLVEKEREKEVSDDEADDEKKE----GDEKKEMETDEPKIEDVGEDEDADKKDKD 258
            |||||||||.|.:||:|||||..:|.:.:::|    |::|     |:|||||:|.|||.|.||..
Zfish   208 HSQFIGYPITLYIEKQREKEVDLEEGEKQEEEEVAAGEDK-----DKPKIEDLGADEDEDSKDGK 267

  Fly   259 AKKKKTIKEKYTEDEELNKTKPIWTRNPDDISQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFR 323
            .|:||.:||||.:.:||||||||||||||||:.||||||||||:|||||||||||||||||||||
Zfish   268 NKRKKKVKEKYIDAQELNKTKPIWTRNPDDITNEEYGEFYKSLSNDWEDHLAVKHFSVEGQLEFR 332

  Fly   324 ALLFIPRRTPFDLFENQKKRNNIKLYVRRVFIMDNCEDLIPEYLNFMKGVVDSEDLPLNISREML 388
            ||||:|||..||||||:||||||||||||||||||||:||||||||:||||||||||||||||||
Zfish   333 ALLFVPRRAAFDLFENKKKRNNIKLYVRRVFIMDNCEELIPEYLNFIKGVVDSEDLPLNISREML 397

  Fly   389 QQNKVLKVIRKNLVKKTMELIEELTEDKENYKKFYDQFSKNLKLGVHEDSNNRAKLADFLRFHTS 453
            ||:|:|||||||||||.::|..||.|||:||||:|:|||||:|||:||||.||.||:|.||::||
Zfish   398 QQSKILKVIRKNLVKKCLDLFTELAEDKDNYKKYYEQFSKNIKLGIHEDSQNRKKLSDLLRYYTS 462

  Fly   454 ASGDDFCSLADYVSRMKDNQKHVYFITGESKDQVSNSAFVERVKARGFEVVYMTEPIDEYVIQHL 518
            ||||:..||.||||||||.|||:|:||||:||||:|||||||::..|.||:||.||||||.:|.|
Zfish   463 ASGDEMVSLKDYVSRMKDTQKHIYYITGETKDQVANSAFVERLRKAGLEVIYMIEPIDEYCVQQL 527

  Fly   519 KEYKGKQLVSVTKEGLELPEDESEKKKREEDKAKFESLCKLMKSILDNKVEKVVVSNRLVDSPCC 583
            |||.||.|||||||||||||||.||||::|.|||:|:|||:||.|||.|:|||.||||||.||||
Zfish   528 KEYDGKNLVSVTKEGLELPEDEEEKKKQDELKAKYENLCKIMKDILDKKIEKVTVSNRLVSSPCC 592

  Fly   584 IVTSQFGWSANMERIMKAQALRDTATMGYMAGKKQLEINPDHPIVETLRQKADADKNDKAVKDLV 648
            ||||.:||:||||||||:|||||.:|||||..||.|||||.||||||||:||:|:||||||||||
Zfish   593 IVTSTYGWTANMERIMKSQALRDNSTMGYMTAKKHLEINPAHPIVETLREKAEAEKNDKAVKDLV 657

  Fly   649 ILLFETSLLSSGFSLDSPQVHASRIYRMIKLGLGIDEDEPMTTDDAQSAGDAPSLVEDTEDASHM 713
            ||||||:||||||:||.||.||:|||||||||||||:|:.:..:.:|.|.:...::|..:|.|.|
Zfish   658 ILLFETALLSSGFTLDDPQTHANRIYRMIKLGLGIDDDDSVVEEISQPAEEDMPVLEGDDDTSRM 722

  Fly   714 EEVD 717
            ||||
Zfish   723 EEVD 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp83	NP_001261362.1	PTZ00272	6..717	CDD:240341	539/714 (75%)
		HATPase_c	28..179	CDD:214643	123/150 (82%)
		HSP90	184..706	CDD:278607	384/525 (73%)
hsp90aa1.1	NP_571403.1	PTZ00272	16..726	CDD:240341	539/714 (75%)
		HATPase_c	38..189	CDD:214643	123/150 (82%)
		HSP90	194..716	CDD:278607	385/526 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	229..274		20/49 (41%)
		Required for homodimerization. /evidence=ECO:0000250\|UniProtKB:P07900	676..726		25/49 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	698..726		8/27 (30%)
		TPR repeat-binding. /evidence=ECO:0000250\|UniProtKB:P07900	717..726		5/8 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580778
Domainoid	1	1.000	834	1.000	Domainoid score	I64
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1156	1.000	Inparanoid score	I199
OMA	1	1.010	-	-		QHG62690
OrthoDB	1	1.010	-	-		D174605at33208
OrthoFinder	1	1.000	-	-		FOG0000295
OrthoInspector	1	1.000	-	-		otm25280
orthoMCL	1	0.900	-	-		OOG6_100204
Panther	1	1.100	-	-	O	PTHR11528
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X234
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910