DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp83 and hsp90ab1

DIOPT Version :9

Sequence 1:	NP_001261362.1	Gene:	Hsp83 / 38389	FlyBaseID:	FBgn0001233	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_571385.2	Gene:	hsp90ab1 / 30573	ZFINID:	ZDB-GENE-990415-95	Length:	725	Species:	Danio rerio

Alignment Length:	718	Identity:	571/718 - (79%)
Similarity:	642/718 - (89%)	Gaps:	4/718 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EEAETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELYIK 67
            ||||||||||||||||||||||||||||||||||:||||||||||||||||||:||||||:|.|.
Zfish     9 EEAETFAFQAEIAQLMSLIINTFYSNKEIFLRELVSNASDALDKIRYESLTDPTKLDSGKDLKID 73

  Fly    68 LIPNKTAGTLTIIDTGIGMTKSDLVNNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLV 132
            :|||....|||:|||||||||:||:||||||||||||||||||||||||||||||||||||||||
Zfish    74 IIPNVQERTLTLIDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLV 138

  Fly   133 ADKVTVTSKNNDDEQYVWESSAGGSFTVRADNSEPLGRGTKIVLYIKEDQTDYLEESKIKEIVNK 197
            |:||||.:|:||||||.|||||||||||:.|:.||:|||||::|::|||||:|:||.::||:|.|
Zfish   139 AEKVTVITKHNDDEQYAWESSAGGSFTVKVDHGEPIGRGTKVILHLKEDQTEYIEEKRVKEVVKK 203

  Fly   198 HSQFIGYPIKLLVEKEREKEVSDDEADDEKKEGDEKKEMETDEPKIEDVGEDEDADKKDKDAKKK 262
            |||||||||.|.|||||:||:|||||::||.|.:||:|...|:|||||||.|::.|.||||.|||
Zfish   204 HSQFIGYPITLYVEKERDKEISDDEAEEEKAEKEEKEEEGEDKPKIEDVGSDDEEDTKDKDKKKK 268

  Fly   263 KTIKEKYTEDEELNKTKPIWTRNPDDISQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLF 327
            |.|||||.:.||||||||||||||||||.||||||||||||||||||||||||||||||||||||
Zfish   269 KKIKEKYIDQEELNKTKPIWTRNPDDISNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLF 333

  Fly   328 IPRRTPFDLFENQKKRNNIKLYVRRVFIMDNCEDLIPEYLNFMKGVVDSEDLPLNISREMLQQNK 392
            ||||.|||||||:||:|||||||||||||||||:||||||||::|||||||||||||||||||:|
Zfish   334 IPRRAPFDLFENKKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSK 398

  Fly   393 VLKVIRKNLVKKTMELIEELTEDKENYKKFYDQFSKNLKLGVHEDSNNRAKLADFLRFHTSASGD 457
            :|||||||:|||.:||..||.|||:|||||||.||||||||:||||.||.||::.||:.:|.|||
Zfish   399 ILKVIRKNIVKKCLELFAELAEDKDNYKKFYDAFSKNLKLGIHEDSQNRKKLSELLRYQSSQSGD 463

  Fly   458 DFCSLADYVSRMKDNQKHVYFITGESKDQVSNSAFVERVKARGFEVVYMTEPIDEYVIQHLKEYK 522
            :..||.:||||||:|||.:|:|||||||||::|||||||..|||||:|||||||||.:|.||::.
Zfish   464 EMTSLTEYVSRMKENQKSIYYITGESKDQVAHSAFVERVCKRGFEVLYMTEPIDEYCVQQLKDFD 528

  Fly   523 GKQLVSVTKEGLELPEDESEKKKREEDKAKFESLCKLMKSILDNKVEKVVVSNRLVDSPCCIVTS 587
            ||.|||||||||||||||.||||.||||||||:||||||.|||.|||||.||||||.||||||||
Zfish   529 GKSLVSVTKEGLELPEDEDEKKKMEEDKAKFENLCKLMKEILDKKVEKVTVSNRLVSSPCCIVTS 593

  Fly   588 QFGWSANMERIMKAQALRDTATMGYMAGKKQLEINPDHPIVETLRQKADADKNDKAVKDLVILLF 652
            .:||:||||||||||||||.:|||||..||.|||||||||:|||||||:||||||||||||||||
Zfish   594 TYGWTANMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIMETLRQKAEADKNDKAVKDLVILLF 658

  Fly   653 ETSLLSSGFSLDSPQVHASRIYRMIKLGLGIDEDEPMTTDDAQSAG---DAPSLVEDTEDASHME 714
            ||:|||||||||.||.|::||||||||||||||||.:..::..||.   |.|.| |..:|||.||
Zfish   659 ETALLSSGFSLDDPQTHSNRIYRMIKLGLGIDEDEDVPVEEPSSAAAPEDIPPL-EGDDDASRME 722

  Fly   715 EVD 717
            |||
Zfish   723 EVD 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp83	NP_001261362.1	PTZ00272	6..717	CDD:240341	566/713 (79%)
		HATPase_c	28..179	CDD:214643	124/150 (83%)
		HSP90	184..706	CDD:278607	408/524 (78%)
hsp90ab1	NP_571385.2	PTZ00272	13..725	CDD:240341	565/712 (79%)
		HATPase_c	34..185	CDD:214643	124/150 (83%)
		HSP90	190..715	CDD:278607	409/525 (78%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	220..269		30/48 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	691..725		15/34 (44%)
		TPR repeat-binding	721..725		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580777
Domainoid	1	1.000	834	1.000	Domainoid score	I64
eggNOG	1	0.900	-	-		E1_COG0326
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74306
Inparanoid	1	1.050	1156	1.000	Inparanoid score	I199
OMA	1	1.010	-	-		QHG62690
OrthoDB	1	1.010	-	-		D174605at33208
OrthoFinder	1	1.000	-	-		FOG0000295
OrthoInspector	1	1.000	-	-		otm25280
orthoMCL	1	0.900	-	-		OOG6_100204
Panther	1	1.100	-	-	LDO	PTHR11528
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R576
SonicParanoid	1	1.000	-	-		X234
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800