DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp83 and Hsp90ab1

DIOPT Version :9

Sequence 1:	NP_001261362.1	Gene:	Hsp83 / 38389	FlyBaseID:	FBgn0001233	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001004082.3	Gene:	Hsp90ab1 / 301252	RGDID:	1303075	Length:	724	Species:	Rattus norvegicus

Alignment Length:	716	Identity:	564/716 - (78%)
Similarity:	638/716 - (89%)	Gaps:	2/716 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EEAETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELYIK 67
            ||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|.
  Rat    10 EEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKID 74

  Fly    68 LIPNKTAGTLTIIDTGIGMTKSDLVNNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLV 132
            :|||....|||::||||||||:||:||||||||||||||||||||||||||||||||||||||||
  Rat    75 IIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLV 139

  Fly   133 ADKVTVTSKNNDDEQYVWESSAGGSFTVRADNSEPLGRGTKIVLYIKEDQTDYLEESKIKEIVNK 197
            |:||.|.:|:||||||.||||||||||||||:.||:|||||::|::|||||:||||.::||:|.|
  Rat   140 AEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKK 204

  Fly   198 HSQFIGYPIKLLVEKEREKEVSDDEADDEKKEGDEKKEMETDEPKIEDVGEDEDADKKDKDAKKK 262
            |||||||||.|.:|||||||:|||||::||.|.:|:.:.:.::|||||||.||: |...||.|||
  Rat   205 HSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEEDKEDEEKPKIEDVGSDEE-DDSGKDKKKK 268

  Fly   263 -KTIKEKYTEDEELNKTKPIWTRNPDDISQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALL 326
             |.|||||.:.|||||||||||||||||:||||||||||||||||||||||||||||||||||||
  Rat   269 TKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALL 333

  Fly   327 FIPRRTPFDLFENQKKRNNIKLYVRRVFIMDNCEDLIPEYLNFMKGVVDSEDLPLNISREMLQQN 391
            |||||.|||||||:||:||||||||||||||:|::||||||||::|||||||||||||||||||:
  Rat   334 FIPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQS 398

  Fly   392 KVLKVIRKNLVKKTMELIEELTEDKENYKKFYDQFSKNLKLGVHEDSNNRAKLADFLRFHTSASG 456
            |:|||||||:|||.:||..||.||||||||||:.||||||||:||||.||.:|::.||:|||.||
  Rat   399 KILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSG 463

  Fly   457 DDFCSLADYVSRMKDNQKHVYFITGESKDQVSNSAFVERVKARGFEVVYMTEPIDEYVIQHLKEY 521
            |:..||::||||||:.||.:|:||||||:||:||||||||:.|||||||||||||||.:|.|||:
  Rat   464 DEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEF 528

  Fly   522 KGKQLVSVTKEGLELPEDESEKKKREEDKAKFESLCKLMKSILDNKVEKVVVSNRLVDSPCCIVT 586
            .||.|||||||||||||||.||||.||.|||||:||||||.|||.|||||.:|||||.|||||||
  Rat   529 DGKSLVSVTKEGLELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVT 593

  Fly   587 SQFGWSANMERIMKAQALRDTATMGYMAGKKQLEINPDHPIVETLRQKADADKNDKAVKDLVILL 651
            |.:||:||||||||||||||.:|||||..||.|||||||||||||||||:||||||||||||:||
  Rat   594 STYGWTANMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLL 658

  Fly   652 FETSLLSSGFSLDSPQVHASRIYRMIKLGLGIDEDEPMTTDDAQSAGDAPSLVEDTEDASHMEEV 716
            |||:||||||||:.||.|::||||||||||||||||....:.:.:..|....:|..||||.||||
  Rat   659 FETALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVTAEEPSAAVPDEIPPLEGDEDASRMEEV 723

  Fly   717 D 717
            |
  Rat   724 D 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp83	NP_001261362.1	PTZ00272	6..717	CDD:240341	560/711 (79%)
		HATPase_c	28..179	CDD:214643	127/150 (85%)
		HSP90	184..706	CDD:278607	398/522 (76%)
Hsp90ab1	NP_001004082.3	Interaction with TP53. /evidence=ECO:0000250\|UniProtKB:P08238	2..527		412/517 (80%)
		Interaction with BIRC2. /evidence=ECO:0000250\|UniProtKB:P08238	2..214		172/203 (85%)
		Interaction with NR3C1. /evidence=ECO:0000250\|UniProtKB:P11499	9..231		185/220 (84%)
		HSP90	14..724	CDD:332554	559/710 (79%)
		Interaction with AHSA1. /evidence=ECO:0000250\|UniProtKB:P08238	215..552		260/337 (77%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	222..270		27/48 (56%)
		Interaction with NR3C1. /evidence=ECO:0000250\|UniProtKB:P11499	264..608		277/343 (81%)
		Interaction with NR1D1. /evidence=ECO:0000250\|UniProtKB:P11499	620..723		72/102 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	694..724		10/29 (34%)
		TPR repeat-binding	720..724		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340909
Domainoid	1	1.000	821	1.000	Domainoid score	I62
eggNOG	1	0.900	-	-		E1_COG0326
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74306
Inparanoid	1	1.050	1144	1.000	Inparanoid score	I201
OMA	1	1.010	-	-		QHG62690
OrthoDB	1	1.010	-	-		D174605at33208
OrthoFinder	1	1.000	-	-		FOG0000295
OrthoInspector	1	1.000	-	-		otm46134
orthoMCL	1	0.900	-	-		OOG6_100204
Panther	1	1.100	-	-	LDO	PTHR11528
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X234
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770