DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp83 and Hsp90b1

DIOPT Version :9

Sequence 1:	NP_001261362.1	Gene:	Hsp83 / 38389	FlyBaseID:	FBgn0001233	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_035761.1	Gene:	Hsp90b1 / 22027	MGIID:	98817	Length:	802	Species:	Mus musculus

Alignment Length:	729	Identity:	350/729 - (48%)
Similarity:	485/729 - (66%)	Gaps:	31/729 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EEAETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELYIK 67
            |::|.||||||:.::|.||||:.|.|||||||||||||||||||||..||||.:.|...:||.:|
Mouse    71 EKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALAGNEELTVK 135

  Fly    68 LIPNKTAGTLTIIDTGIGMTKSDLVNNLGTIAKSGTKAFM----EALQAGADIS-MIGQFGVGFY 127
            :..:|....|.:.|||:|||:.:||.||||||||||..|:    ||.:.|...| :|||||||||
Mouse   136 IKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFY 200

  Fly   128 SAYLVADKVTVTSKNNDDEQYVWESSAGGSFTVRAD-NSEPLGRGTKIVLYIKEDQTDYLEESKI 191
            ||:||||||.||||:|:|.|::|||.: ..|:|.|| ....|||||.|.|.:||:.:||||...|
Mouse   201 SAFLVADKVIVTSKHNNDTQHIWESDS-NEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTI 264

  Fly   192 KEIVNKHSQFIGYPIKLLVEKER--EKEVSDDEADDEKKEGDEKKEMETDEPKIEDVGEDEDADK 254
            |.:|.|:||||.:||.:...|..  |:.:.:|||..|:||       |:|:   |...|:|:.:|
Mouse   265 KNLVRKYSQFINFPIYVWSSKTETVEEPLEEDEAAKEEKE-------ESDD---EAAVEEEEEEK 319

  Fly   255 KDKDAKKKKTIKEKYTEDEELNKTKPIWTRNPDDISQEEYGEFYKSLTNDWEDHLAVKHFSVEGQ 319
            |.|..|.:||:    .:.|.:|..||||.|...::.::||..||||.:.:.:|.:|..||:.||:
Mouse   320 KPKTKKVEKTV----WDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGE 380

  Fly   320 LEFRALLFIPRRTPFDLFE--NQKKRNNIKLYVRRVFIMDNCEDLIPEYLNFMKGVVDSEDLPLN 382
            :.|:::||:|...|..||:  ..||.:.||||||||||.|:..|::|:||||:||||||:|||||
Mouse   381 VTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLN 445

  Fly   383 ISREMLQQNKVLKVIRKNLVKKTMELIEELTEDKENYKKFYDQFSKNLKLGVHEDSNNRAKLADF 447
            :|||.|||:|:||||||.||:||:::|:::.::|.| ..|:.:|..|:||||.||.:||.:||..
Mouse   446 VSRETLQQHKLLKVIRKKLVRKTLDMIKKIADEKYN-DTFWKEFGTNIKLGVIEDHSNRTRLAKL 509

  Fly   448 LRFHTSASGDDFCSLADYVSRMKDNQKHVYFITGESKDQVSNSAFVERVKARGFEVVYMTEPIDE 512
            |||.:|....|..||..||.|||:.|..:||:.|.|:.:..:|.||||:..:|:||:|:|||:||
Mouse   510 LRFQSSHHSTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDE 574

  Fly   513 YVIQHLKEYKGKQLVSVTKEGLELPEDESEKKKREEDKAKFESLCKLMK-SILDNKVEKVVVSNR 576
            |.||.|.|:.||:..:|.|||::..|.|..|:.||..:.:||.|...|| ..|.:|:||.|||.|
Mouse   575 YCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREATEKEFEPLLNWMKDKALKDKIEKAVVSQR 639

  Fly   577 LVDSPCCIVTSQFGWSANMERIMKAQAL---RDTATMGYMAGKKQLEINPDHPIVETLRQKADAD 638
            |.:|||.:|.||:|||.||||||||||.   :|.:|..|.:.||..||||.||::..:.::...|
Mouse   640 LTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKED 704

  Fly   639 KNDKAVKDLVILLFETSLLSSGFSLDSPQVHASRIYRMIKLGLGIDEDEPMTTDDAQSAGDAPSL 703
            ::||.|.||.::||||:.|.||:.|...:.:..||.||::|.|.||.:..:..:..:...|....
Mouse   705 EDDKTVMDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPEAQVEEEPEEEPEDTSED 769

  Fly   704 VEDTEDASHMEEVD 717
            .||:|. ...||:|
Mouse   770 AEDSEQ-DEGEEMD 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp83	NP_001261362.1	PTZ00272	6..717	CDD:240341	348/724 (48%)
		HATPase_c	28..179	CDD:214643	92/156 (59%)
		HSP90	184..706	CDD:278607	236/529 (45%)
Hsp90b1	NP_035761.1	PRK05218	74..746	CDD:235366	338/687 (49%)
		HATPase_c	96..254	CDD:214643	93/158 (59%)
		HSP90	257..783	CDD:278607	242/542 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	290..323		14/42 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	749..802		9/35 (26%)
		Prevents secretion from ER	799..802
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0326
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000295
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100204
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X234
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.710