Protein Alignment Hsp83 and hsp-90

DIOPT Version :9

• Sequence 1: NP_001261362.1
• Gene: Hsp83 / 38389
• FlyBaseID: FBgn0001233
• Length: 717
• Species: Drosophila melanogaster
• Sequence 2: NP_506626.1
• Gene: hsp-90 / 179971
• WormBaseID: WBGene00000915
• Length: 702
• Species: Caenorhabditis elegans
• Alignment Length: 723
• Identity: 545/723 - (75%)
• Similarity: 620/723 - (85%)
• Gaps: 27/723 - (3%)

  Fly     1 MPEEAETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELY 65
            |.|.|||||||||||||||||||||||||||:|||||||||||||||||::||:||:||:||||:
 Worm     1 MSENAETFAFQAEIAQLMSLIINTFYSNKEIYLRELISNASDALDKIRYQALTEPSELDTGKELF 65

  Fly    66 IKLIPNKTAGTLTIIDTGIGMTKSDLVNNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAY 130
            ||:.|||...||||:||||||||:||||||||||||||||||||||||||||||||||||||||:
 Worm    66 IKITPNKEEKTLTIMDTGIGMTKADLVNNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAF 130

  Fly   131 LVADKVTVTSKNNDDEQYVWESSAGGSFTVRADNSEPLGRGTKIVLYIKEDQTDYLEESKIKEIV 195
            ||||||.||||||||:.|.|||||||||.||..|...:.||||||::|||||.|:|||.||||||
 Worm   131 LVADKVVVTSKNNDDDSYQWESSAGGSFVVRPFNDPEVTRGTKIVMHIKEDQIDFLEERKIKEIV 195

  Fly   196 NKHSQFIGYPIKLLVEKEREKEVSDDEA----DDEKKEGDEKKEMETDEPKIEDVGEDEDADKKD 256
            .||||||||||||:|||||||||.|:||    |:|||||:           :|:|.  :||||
 Worm   196 KKHSQFIGYPIKLVVEKEREKEVEDEEAVEAKDEEKKEGE-----------VENVA--DDADK-- 245

  Fly   257 KDAKKKKTIKEKYTEDEELNKTKPIWTRNPDDISQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLE 321
               ||.|.|||||.||||||||||||||||||||.|||.||||||:|||||||||||||||||||
 Worm   246 ---KKTKKIKEKYFEDEELNKTKPIWTRNPDDISNEEYAEFYKSLSNDWEDHLAVKHFSVEGQLE 307

  Fly   322 FRALLFIPRRTPFDLFENQKKRNNIKLYVRRVFIMDNCEDLIPEYLNFMKGVVDSEDLPLNISRE 386
            ||||||:|:|.|||||||:|.:|:|||||||||||:|||:|:||||||:||||||||||||||||
 Worm   308 FRALLFVPQRAPFDLFENKKSKNSIKLYVRRVFIMENCEELMPEYLNFIKGVVDSEDLPLNISRE 372

  Fly   387 MLQQNKVLKVIRKNLVKKTMELIEELTEDKENYKKFYDQFSKNLKLGVHEDSNNRAKLADFLRFH 451
            ||||:|:|||||||||||.||||:|:.|||:|:||||:||.||||||:||||.||.||:||||:.
 Worm   373 MLQQSKILKVIRKNLVKKCMELIDEVAEDKDNFKKFYEQFGKNLKLGIHEDSTNRKKLSDFLRYS 437

  Fly   452 TSASGDDFCSLADYVSRMKDNQKHVYFITGESKDQVSNSAFVERVKARGFEVVYMTEPIDEYVIQ 516
            ||| ||:..||.:||||||:||..:|:|||||||.|:.||||||||:|||||:||.:|||||.:|
 Worm   438 TSA-GDEPTSLKEYVSRMKENQTQIYYITGESKDVVAASAFVERVKSRGFEVLYMCDPIDEYCVQ 501

  Fly   517 HLKEYKGKQLVSVTKEGLELPEDESEKKKREEDKAKFESLCKLMKSILDNKVEKVVVSNRLVDSP 581
            .||||.||:|||||||||||||.|.||||.||||..:|:|||::|.||:.|||||.||||||.||
 Worm   502 QLKEYDGKKLVSVTKEGLELPETEEEKKKFEEDKVAYENLCKVIKDILEKKVEKVGVSNRLVSSP 566

  Fly   582 CCIVTSQFGWSANMERIMKAQALRDTATMGYMAGKKQLEINPDHPIVETLRQKADADKNDKAVKD 646
            ||||||::|||||||||||||||||::||||||.||.|||||||.|::|||.:.:.|||||.|||
 Worm   567 CCIVTSEYGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHAIMKTLRDRVEVDKNDKTVKD 631

  Fly   647 LVILLFETSLLSSGFSLDSPQVHASRIYRMIKLGLGIDEDEPMTTDDA-QSAGDAPSLVEDT-ED 709
            ||:|||||:||:|||||:.||.|||||||||||||.|.:||  ..|.| .|:..|.:.:|.. ||
 Worm   632 LVVLLFETALLASGFSLEEPQSHASRIYRMIKLGLDIGDDE--IEDSAVPSSCTAEAKIEGAEED 694

  Fly   710 ASHMEEVD 717
            ||.|||||
 Worm   695 ASRMEEVD 702

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp83	NP_001261362.1	PTZ00272	6..717	CDD:240341	540/716 (75%)
		HATPase_c	28..179	CDD:214643	121/150 (81%)
		HSP90	184..706	CDD:278607	384/526 (73%)
hsp-90	NP_506626.1	PTZ00272	6..702	CDD:240341	540/716 (75%)
		HATPase_c	33..181	CDD:280651	119/147 (81%)
		HSP90	184..702	CDD:278607	392/538 (73%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159389
Domainoid	1	1.000	755	1.000	Domainoid score	I35
eggNOG	1	0.900	-	-		E1_COG0326
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74306
Inparanoid	1	1.050	1057	1.000	Inparanoid score	I131
Isobase	1	0.950	-	0	Normalized mean entropy	S263
OMA	1	1.010	-	-		QHG62690
OrthoDB	1	1.010	-	-		D174605at33208
OrthoFinder	1	1.000	-	-		FOG0000295
OrthoInspector	1	1.000	-	-		oto17849
orthoMCL	1	0.900	-	-		OOG6_100204
Panther	1	1.100	-	-	LDO	PTHR11528
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R576
SonicParanoid	1	1.000	-	-		X234
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	16	15.790