DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp83 and Hsp90aa1

DIOPT Version :9

Sequence 1:	NP_001261362.1	Gene:	Hsp83 / 38389	FlyBaseID:	FBgn0001233	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_034610.1	Gene:	Hsp90aa1 / 15519	MGIID:	96250	Length:	733	Species:	Mus musculus

Alignment Length:	721	Identity:	571/721 - (79%)
Similarity:	646/721 - (89%)	Gaps:	8/721 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EEAETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELYIK 67
            ||.||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||:|.
Mouse    15 EEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHIN 79

  Fly    68 LIPNKTAGTLTIIDTGIGMTKSDLVNNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLV 132
            |||:|...||||:||||||||:||:||||||||||||||||||||||||||||||||||||||||
Mouse    80 LIPSKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLV 144

  Fly   133 ADKVTVTSKNNDDEQYVWESSAGGSFTVRADNSEPLGRGTKIVLYIKEDQTDYLEESKIKEIVNK 197
            |:||||.:|:||||||.||||||||||||.|..||:|||||::|::|||||:||||.:|||||.|
Mouse   145 AEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKK 209

  Fly   198 HSQFIGYPIKLLVEKEREKEVSDDEAD--DEKKEGDEKKEMETDE-PKIEDVGED-EDADKKDKD 258
            |||||||||.|.|||||:||||||||:  :||:|..||:|.|:|: |:|||||.| |:.:|||.|
Mouse   210 HSQFIGYPITLFVEKERDKEVSDDEAEEKEEKEEEKEKEEKESDDKPEIEDVGSDEEEEEKKDGD 274

  Fly   259 AKKKKTIKEKYTEDEELNKTKPIWTRNPDDISQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFR 323
            .||||.|||||.:.|||||||||||||||||:.|||||||||||||||:||||||||||||||||
Mouse   275 KKKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEEHLAVKHFSVEGQLEFR 339

  Fly   324 ALLFIPRRTPFDLFENQKKRNNIKLYVRRVFIMDNCEDLIPEYLNFMKGVVDSEDLPLNISREML 388
            ||||:|||.|||||||:||:|||||||||||||||||:||||||||::|||||||||||||||||
Mouse   340 ALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREML 404

  Fly   389 QQNKVLKVIRKNLVKKTMELIEELTEDKENYKKFYDQFSKNLKLGVHEDSNNRAKLADFLRFHTS 453
            ||:|:|||||||||||.:||..||.||||||||||:|||||:|||:||||.||.||::.||::||
Mouse   405 QQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTS 469

  Fly   454 ASGDDFCSLADYVSRMKDNQKHVYFITGESKDQVSNSAFVERVKARGFEVVYMTEPIDEYVIQHL 518
            ||||:..||.||.:|||:||||:||||||:||||:|||||||::..|.||:||.||||||.:|.|
Mouse   470 ASGDEMVSLKDYCTRMKENQKHIYFITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQL 534

  Fly   519 KEYKGKQLVSVTKEGLELPEDESEKKKREEDKAKFESLCKLMKSILDNKVEKVVVSNRLVDSPCC 583
            ||::||.|||||||||||||||.||||:||.|.|||:|||:||.||:.||||||||||||.||||
Mouse   535 KEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCC 599

  Fly   584 IVTSQFGWSANMERIMKAQALRDTATMGYMAGKKQLEINPDHPIVETLRQKADADKNDKAVKDLV 648
            ||||.:||:||||||||||||||.:||||||.||.|||||||.|:|||||||:||||||:|||||
Mouse   600 IVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLV 664

  Fly   649 ILLFETSLLSSGFSLDSPQVHASRIYRMIKLGLGIDEDEPMTTDDAQSA--GDAPSLVEDTEDAS 711
            |||:||:||||||||:.||.||:|||||||||||||||:| |.||..:|  .:.|.| |..:|.|
Mouse   665 ILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDP-TVDDTSAAVTEEMPPL-EGDDDTS 727

  Fly   712 HMEEVD 717
            .|||||
Mouse   728 RMEEVD 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp83	NP_001261362.1	PTZ00272	6..717	CDD:240341	567/716 (79%)
		HATPase_c	28..179	CDD:214643	128/150 (85%)
		HSP90	184..706	CDD:278607	406/527 (77%)
Hsp90aa1	NP_034610.1	Interaction with NR3C1. /evidence=ECO:0000269\|PubMed:27686098	9..236		189/220 (86%)
		PTZ00272	18..733	CDD:240341	567/716 (79%)
		HATPase_c	40..191	CDD:214643	128/150 (85%)
		HSP90	196..723	CDD:278607	407/528 (77%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	225..279		32/53 (60%)
		Interaction with NR3C1. /evidence=ECO:0000269\|PubMed:27686098	272..617		275/344 (80%)
		Interaction with FLCN and FNIP1. /evidence=ECO:0000250\|UniProtKB:P07900	285..733		351/449 (78%)
		Interaction with FNIP2 and TSC1. /evidence=ECO:0000250\|UniProtKB:P07900	285..621		269/335 (80%)
		Interaction with NR1D1. /evidence=ECO:0000269\|PubMed:27686098	629..732		74/104 (71%)
		Required for homodimerization. /evidence=ECO:0000250\|UniProtKB:P07900	683..733		31/51 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	701..733		15/33 (45%)
		TPR repeat-binding. /evidence=ECO:0000250\|UniProtKB:P07900	724..733		5/8 (63%)
		Essential for interaction with SMYD3, TSC1 and STIP1/HOP. /evidence=ECO:0000250\|UniProtKB:P07900	729..733		3/3 (100%)
		Essential for interaction with SGTA and TTC1. /evidence=ECO:0000250\|UniProtKB:P07900	730..733		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837192
Domainoid	1	1.000	822	1.000	Domainoid score	I63
eggNOG	1	0.900	-	-		E1_COG0326
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1143	1.000	Inparanoid score	I211
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62690
OrthoDB	1	1.010	-	-		D174605at33208
OrthoFinder	1	1.000	-	-		FOG0000295
OrthoInspector	1	1.000	-	-		otm44045
orthoMCL	1	0.900	-	-		OOG6_100204
Panther	1	1.100	-	-	O	PTHR11528
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R576
SonicParanoid	1	1.000	-	-		X234
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.800