DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Girdin and HOOK3

DIOPT Version :9

Sequence 1:	NP_647780.1	Gene:	Girdin / 38385	FlyBaseID:	FBgn0283724	Length:	1381	Species:	Drosophila melanogaster
Sequence 2:	NP_115786.1	Gene:	HOOK3 / 84376	HGNCID:	23576	Length:	718	Species:	Homo sapiens

Alignment Length:	727	Identity:	171/727 - (23%)
Similarity:	314/727 - (43%)	Gaps:	163/727 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 SIISWLESCLPRAELLAGYTSLLDGHIIHSVWLQIDPE--PQNNPSELNDLNGKSLSIARAKNFE 81
            |:::|:::....|.... ...|.:|.::..|..:|||.  .:|..:.:....|.:..: :..|.:
Human    15 SLLTWIQTFNVDAPCQT-VEDLTNGVVMAQVLQKIDPAYFDENWLNRIKTEVGDNWRL-KISNLK 77

  Fly    82 CVVRNLKSFFEEELGQTI--LVLPDAFTLGHHPESKNGLEQMKTLLTLLLGAAVQCPNKELFIAR 144
            .:::.:..:..|.|||.|  ..|||...:|.|.::    .::..:|.|:||.||.|..|:.:|..
Human    78 KILKGILDYNHEILGQQINDFTLPDVNLIGEHSDA----AELGRMLQLILGCAVNCEQKQEYIQA 138

  Fly   145 IKELDLETQHAIVGLIKQVTDSHSLV----------------LTEDSLERLTPQSMYTHILRLTK 193
            |..::...||.::..|:::....|.|                .||:..|.|:.:.   .|.:...
Human   139 IMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSAKE---EIAQRCH 200

  Fly   194 ERDVMYLKWIDLACVETEMTA--SDNLVECGQGVSVTRSPSNGTATSTPSSSSNSESNHLAVECA 256
            |.|      :.:|.::.|.::  ::|.|       :....:...:...|:|.:.  ..||
Human   201 ELD------MQVAALQEEKSSLLAENQV-------LMERLNQSDSIEDPNSPAG--RRHL----- 245

  Fly   257 DLRSKNRKLRQELEEKSENLLELREELDDKKAR-------FDKLRQESQEWFTEAKRASAYRDEV 314
                   :|:.:||:..|....|....||.:.|       ..:|||::.|..|.|..|.:.:||:
Human   246 -------QLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEI 303

  Fly   315 DILRERAERADRLEVEVQKYREKLGDSDFYKSRVEELREDNRVLLESKEMLEE----------QL 369
            |:||..:::..:||.:|:.|::||.|....:.:|:.|.|.|.:.:::...|||          ||
Human   304 DVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQL 368

  Fly   370 QRYRKR-----------SEHAISLESEIIKYKQKINDMALERD---VDRSKLEELLEE-----NS 415
            :.|:::           |:.|..|:.|..:.|:|::.:..|:|   .:|..|:|.:||     ..
Human   369 ETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQ 433

  Fly   416 QLQLVARNL-------------------------------NSTMDLDKSFSENEDDCNSGDNSLS 449
            :.||..:.|                               |..:.|::..|:||      ..:|.
Human   434 EGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNE------KIALL 492

  Fly   450 EQLTNNAQTRALKLELENR----RLTAALEQLKE--SSFHESTSKMLELEKEKKKLSLKIEQMQE 508
            :.|.::|..|..:||.|||    ||.....|::|  .|..:..||..:....||||...:|::.|
Human   493 QSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHE 557

  Fly   509 NINRLTQQNV---ELEGVFKNALEENKKLQDAVDNRQKSYDRQSLEREADRQKLSDAEQHVETLN 570
            ..|.|.::..   :||..|.|:..:.::||:|:  |:|..:.:.:| |..::.|..|:..:.||:
Human   558 ANNELQKKRAIIEDLEPRFNNSSLKIEELQEAL--RKKEEEMKQME-ERYKKYLEKAKSVIRTLD 619

  Fly   571 -KEKQ----RIQTLNESIQRRADDLERLAESKTKELEQYLEKSRQYELTK-QKLYEIEARVSTYE 629
             |:.|    .||.|...:|.|    :||..|..||          ||.|| |:..|.:..||.:.
Human   620 PKQNQGAAPEIQALKNQLQER----DRLFHSLEKE----------YEKTKSQREMEEKYIVSAWY 670

  Fly   630 RENASLLKEVSK 641
            ....:|.|:.::
Human   671 NMGMTLHKKAAE 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Girdin	NP_647780.1	SMC_prok_B	315..1112	CDD:274008	102/402 (25%)
Girdin	NP_647780.1	SynN	884..1006	CDD:294095
HOOK3	NP_115786.1	Sufficient for interaction with microtubules	1..164		36/154 (23%)
		HkD_Hook3	8..160	CDD:411797	35/150 (23%)
		HOOK	184..709	CDD:398962	132/552 (24%)
		Required for association with Golgi	553..718		41/147 (28%)
		Required for interaction with MSR1. /evidence=ECO:0000269\|PubMed:17237231	556..718		40/144 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	682..718		0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141679
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840