DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Girdin and Hook1

DIOPT Version :9

Sequence 1:	NP_647780.1	Gene:	Girdin / 38385	FlyBaseID:	FBgn0283724	Length:	1381	Species:	Drosophila melanogaster
Sequence 2:	NP_084290.1	Gene:	Hook1 / 77963	MGIID:	1925213	Length:	728	Species:	Mus musculus

Alignment Length:	751	Identity:	184/751 - (24%)
Similarity:	341/751 - (45%)	Gaps:	123/751 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 SIISWLES------CLPRAELLAGYTSLLDGHIIHSV--------WLQIDPEPQNNPSELNDLNG 69
            |:|.||::      |....:|..|.|.   ..::|.:        ||          |.:.|..|
Mouse    17 SLIIWLQTFKTASPCQDVKQLTNGVTM---AQVLHQIDVAWFSESWL----------SRIKDDVG 68

  Fly    70 KSLSIARAKNFECVVRNLKSFFEEELGQTIL--VLPDAFTLGHHPESKNGLEQMKTLLTLLLGAA 132
            .:..| :|.|.:.|:..:.|::.|.|||.|.  ::||   |....|..:.:| :..||.|:||.|
Mouse    69 DNWRI-KASNLKKVLHGITSYYHEFLGQQISEELIPD---LNQITECADPVE-LGRLLQLILGCA 128

  Fly   133 VQCPNKELFIARIKELDLETQHAIVGLIKQVTDSHSLVLT--EDSLERLTPQSMYTHILRLTKER 195
            |.|..|:..|..|..|:...||.::..|:::. |..:|::  .|::..|..|     :.|..:|.
Mouse   129 VNCEKKQEHIKNIMTLEESVQHVVMTAIQELM-SKEIVISPASDTVGELEQQ-----LKRALEEL 187

  Fly   196 DVMYLKWIDL--ACVETEMTAS------DNLVECGQGVSVTRSPSNGTATSTPSSSSNSESNHLA 252
            .....:..:|  .|.|.:|..:      ::||...:.::......:| :...|::....:..|:.
Mouse   188 QEAIAEKEELKQRCQELDMQVTTLQDEKNSLVSENEMMNEKLDQLDG-SFDDPNTMVAKKYFHVQ 251

  Fly   253 VECADLRSKNRKLRQELEEKSENLLELREELDDKKARFDKLRQESQEWFTEAKRASAYRDEVDIL 317
            ::...|:.:|.:|....::...:..||.::|.:.:.|.|:|...::|       ..|.:||:|:|
Mouse   252 LQLEQLQEENYRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEE-------TRALKDEIDVL 309

  Fly   318 RERAERADRLEVEVQKYREKLGDSDFYKSRVEELREDNRVLLESKEMLEEQLQRYRKRSEHAISL 382
            |..:::|::||..|:.||:||.|.:..:.:|:.|:|.|.:.:.:...|||:|::       |.:.
Mouse   310 RATSDKANKLESTVEVYRQKLQDLNDLRKQVKSLQETNMMYMHNTVSLEEELKK-------ANAA 367

  Fly   383 ESEIIKYKQKIND--------------MALERDVDRSKLEELLEENSQLQLVARNLNSTMDLDKS 433
            .:::..||:::.|              :|.|......|.|.||:|..:|......|..|.:..:.
Mouse   368 RAQLETYKRQVQDLHTKLSSESKRADTLAFEMKRLEEKHETLLKEKERLIEQRDTLKETNEELRC 432

  Fly   434 FSENEDDCNSGDNSLSEQLTNNAQTRALKLELENRRLTAALEQLKESSFHESTSKMLELEKEKKK 498
            ....:|..|..|.|.::...|.|   |..:.:|.|.:...|:       ||  :|||.|::|..:
Mouse   433 SKAQQDHLNQADASATKSYENLA---AEIMPVEYREVFIRLQ-------HE--NKMLRLQQEGTE 485

  Fly   499 LSLKIEQMQENINRLTQQNVELEGVFKNALEENKKLQDAVDNRQKSYDRQSLEREAD-----RQK 558
             :.:|||:||.:.:..::..|||...:.:.|...:||..:::.|||...|..:.|.:     :||
Mouse   486 -NERIEQLQEQLEQKHRKMNELETEQRLSKERIGELQQQIEDLQKSLQEQGSKSEGESSSKLKQK 549

  Fly   559 LSDAEQHVETLNKEKQRIQTLNESIQRRADDLERLAESKTKELEQYLEKSRQYELTKQKLYEIEA 623
            |   |.|:|.|.:..:.:|...|.|:....|:.:.|: |..|||..|:|.      .:.:..:|.
Mouse   550 L---EAHMEKLTEVHEELQKKQELIEDLQPDISQNAQ-KISELEAALQKK------DEDMKAMEE 604

  Fly   624 RVSTYERENASLLKEVS-KLKEGSEQKSV---QLDDSINRLDVQSKELQKLGKALEDSEQVHQKL 684
            |...|..:..:::|.:. ||...|.:..:   ||.:...|:::...|. |:.| |.|.|   :||
Mouse   605 RYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIEILESEC-KVAK-LRDYE---EKL 664

  Fly   685 VELEKQNQELASQRIIDQEMISTLRNDLVTGTLVTK 720
            :.....|:.||.|::       .:.:.||:|....|
Mouse   665 IVSAWYNKSLAFQKL-------GMESRLVSGASACK 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Girdin	NP_647780.1	SMC_prok_B	315..1112	CDD:274008	111/429 (26%)
Girdin	NP_647780.1	SynN	884..1006	CDD:294095
Hook1	NP_084290.1	Sufficient for interaction with microtubules. /evidence=ECO:0000250	1..555		145/592 (24%)
		HOOK	14..720	CDD:283312	184/751 (25%)
		Med21	<175..210	CDD:288119	8/39 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	481..510		9/29 (31%)
		DUF342	<502..584	CDD:302792	23/85 (27%)
		Sufficient for interaction with AKTIP and VPS18. /evidence=ECO:0000250	657..728		13/47 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831627
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840