DRSC/TRiP Functional Genomics Resources

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Protein Alignment Girdin and Ccdc88c

DIOPT Version :9

Sequence 1:NP_647780.1 Gene:Girdin / 38385 FlyBaseID:FBgn0283724 Length:1381 Species:Drosophila melanogaster
Sequence 2:NP_080957.2 Gene:Ccdc88c / 68339 MGIID:1915589 Length:2009 Species:Mus musculus


Alignment Length:1691 Identity:449/1691 - (26%)
Similarity:736/1691 - (43%) Gaps:424/1691 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 IDEFVNSSIISWLESC----LPRAELLAGYTSLLDGHIIHSVWLQIDPEPQN---NPSELNDLNG 69
            ::.|:.|.:::|:::.    ....:.|..|..|:||..::.:.|||||.|.|   |....||:| 
Mouse     9 VELFLQSPLVTWVKTFGSFGSGHQDNLTLYMDLVDGIFLNQIMLQIDPRPSNQRINKHVNNDVN- 72

  Fly    70 KSLSIARAKNFECVVRNLKSFFEEELGQTILV-LPDAFTLGHHPESKNGLEQMKTLLTLLLGAAV 133
                 .|.:|...:|||:|::::|.|.|.|:: ||:...:|..|.|...:|::|.:|.|:||.||
Mouse    73 -----LRIQNLSILVRNIKTYYQEVLQQLIVMNLPNVLMIGKDPLSGKSMEEIKKVLLLVLGCAV 132

  Fly   134 QCPNKELFIARIKELDLETQHAIVGLIKQVTDSHSLV----------LTEDSLERLTPQSMYTHI 188
            ||..||.||.|||:||:|||..||..|::||.:...|          :..:.||.|: ::|..|:
Mouse   133 QCERKEEFIERIKQLDIETQAGIVAHIQEVTHNQENVFDLQWLDLPDVAPEELEALS-RNMVFHL 196

  Fly   189 LRLTKERDVMYLKWIDLACVE--TEMTASDNLVECGQGVSVTRSPSNGTATSTPSSSSNSESNHL 251
            .||..|||         .|.|  .::|...:.::..|..|..:..|..:..|..||.|:.:..||
Mouse   197 RRLIDERD---------ECTELIVDLTQERDYLQTQQPPSPGKFSSPDSTPSPTSSLSSEDKQHL 252

  Fly   252 AVECADLRSKNRKLRQELEEKSENLLELREELDDKKARFDKLRQESQEWFTEAKRASAYRDEVDI 316
            |||.||.:::.|::|||||||:|.|.:.|.|:|.......|.:|::.:...:|:.|.|||||:|.
Mouse   253 AVELADTKARLRRVRQELEEKTEQLADTRHEVDQLVLELQKAKQDNIQLAADARSARAYRDELDS 317

  Fly   317 LRERAERADRLEVEVQKYREKLGDSDFYKSRVEELREDNRVLLESKEMLEEQLQRYRKRSEHAIS 381
            |||:|.|.:|||:::.:.:|||.|.||||:|:|||||||.:|:|:|.||||||...|.||:....
Mouse   318 LREKANRVERLEMDLVRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTASRARSDKVHE 382

  Fly   382 LESEIIKYKQKINDMALERDVDRSKLEELLEENSQLQLVAR-NLNSTMDLD---KSFSENEDDCN 442
            ||.|.::.|.|::|:.|:||.|:.::|:||||...|::..: ::..:..|.   :..|:|.|..:
Mouse   383 LEKENLQLKSKLHDLELDRDADKKQIEKLLEEYMVLEMAQKQSMKESAHLGWELEQLSKNADLSD 447

  Fly   443 SGDNSLSEQLTNNAQTRALKLELENRRLTAALEQLKESS--FHESTSKMLELEKEKKKLSLKIEQ 505
            :...|...:|...|.:|.||||.||:.|.:.::.|:::|  ..||:.|..|||||.::||.|||:
Mouse   448 ASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDTSLALEESSLKYGELEKENQQLSKKIEK 512

  Fly   506 MQENINRLTQQNVELEGVFKNALEENKKLQDAV-------------------------------- 538
            :|..:.|..|.|.:||.:.:..:.|.::||..:                                
Mouse   513 LQTQLEREKQSNQDLETLSEELIREKEQLQSGMEALKADRARQIKDLEQEKGHLHQAVWSLRERP 577

  Fly   539 ----------DNR--------------QKSYDRQSLEREADRQK--------------------- 558
                      :||              |...::|.|.|:.:..|                     
Mouse   578 QVNSTKDVEKENRALHQAVTEAGSKLSQLELEKQQLHRDLEEAKEKGEQAEALEKELHRLEKENE 642

  Fly   559 --------LSDAEQHVETLNKEKQRIQTLNESIQRRADDLERLA--------------------- 594
                    |..|.:.||.|..:.|.::..|.|:::..|.|:.::                     
Mouse   643 QLTKEVTSLKAATEKVEALEHQSQGLELENRSLRKSLDTLQNVSVQLEGLERDKQQLGQENLELR 707

  Fly   595 ----------------ESKTKELEQYLE--------------KSRQYELTKQ------------- 616
                            |::.::||:..|              ||.:.||:.|             
Mouse   708 KMVEAMRFTSAKMAQIETENRQLEREKEELRRDVELLKTLSKKSERLELSYQSVSAENLQLQHSL 772

  Fly   617 ------------KLYEIEA-------------------------------RVSTYERENASLLKE 638
                        :|.::||                               .|:..|::...|.||
Mouse   773 ESSTHKSQALQRELSQLEAERQALRRDLETLQLTHKQLEGAEEDRKALEQEVAQLEKDKKLLEKE 837

  Fly   639 VSKLKEGSEQKSVQLDDSINRLDVQSKELQKLGKALEDSEQVHQKLVELEKQNQELASQRIIDQE 703
            ..:|.:..|.|...||||..:|....||.:.|.|.|.....|..||.||||.|::|..|..:...
Mouse   838 ARRLWQQVELKDAILDDSAAKLSAAEKESRALDKELARCRDVGSKLKELEKDNRDLTKQVTMHTR 902

  Fly   704 MISTLRNDLVTGTLVTK-------KVRNNLEKLGLA-------DEEPGE--------------LN 740
            .::|||.|||...|.::       |:...|||:||:       |:..|:              :.
Mouse   903 TLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLSKDLLLQEDDGHGDGKGKTESALKTTLAMK 967

  Fly   741 VEHVV--EKLVRNPETFKTVREIMLNVTREQLEE--EEREGGVKSDMC-------VLCHRQ---- 790
            .|.:|  |..|...|:.....:|.|.:.:::.|:  :.:|||.|:...       |..|::    
Mouse   968 EEKIVFLEAQVEEKESLSRQLQIELQMIKKEHEQLRQTQEGGDKAQNALKRPPGKVTSHQEKEAW 1032

  Fly   791 ---------EIFTV-EKNIELAATPAPAPAQP----------SSQELRFEHKVRLSPARESAELT 835
                     |:..| ::.|||..:.|...|:.          .:|.:.|..:: |:..::||.| 
Mouse  1033 EPSHKEATMELLRVKDRAIELERSNAALQAERQLLKEQLQHLETQNVSFSSQI-LTLQKQSAFL- 1095

  Fly   836 RIKDSNTQLQTENARLSVDVAALGSQITSLNTQHVALQLANSQLAAEKDSLLKEIDSLQQEHKHA 900
              ::..|.|||:.|:|.|:.:.|.||..:|:.|:..||...:...||.:.|.::.:.|...::..
Mouse  1096 --QEHTTTLQTQTAKLQVENSTLSSQNAALSAQYTVLQSQQAAKEAEHEGLQQQQEQLAAVYEAL 1158

  Fly   901 LQDQVTLQCLHDQLSAEYESLNKDKEQLKAAVRDLRQELRDTREQQSALEQRIEELTIQNSNMKT 965
            |||...|..|::..|:|||:|.:....||...|:|..|.::..|:...|:||..||         
Mouse  1159 LQDHKHLGTLYECQSSEYEALIRQHSCLKTLHRNLELEHKELGERHGDLQQRKAEL--------- 1214

  Fly   966 CSEDL-SILRTEHSKLTDDFR-NLFATSD--RFKNEYKNIQEQYKMVRMEHSSLKLQNTELSGEL 1026
              |:| .:|.||...|..:.: |..|||:  |.:.|...|...::.::.|:..|.....||...|
Mouse  1215 --EELEKVLSTEREALEREQKTNAIATSENQRLRGELDRISFLHQQLKGEYEELHAHTKELKTSL 1277

  Fly  1027 NAK--------------SDQVRCLQMEYSKVQQRCEMLIQNNAELDSERKALMDNVSQLLSQYQE 1077
            |..              .:|.:.:.:..:|:...||:|.:....|:.|...|:..:..|..|.|.
Mouse  1278 NNSQLELSRWQVRFDELKEQHQSMDISLTKMDNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQM 1342

  Fly  1078 LLAISLEDKKHFHEEEKNYTERVHSLKRQKEKLEEKIMEHYKKSETTVHKKKPF--ASMLVRRVK 1140
            ||..::|.|:.:|||:|.|.:::::|:|.|||||||||:.||..:....||..:  |..||:.:|
Mouse  1343 LLEQNMESKEQYHEEQKQYIDKLNALRRHKEKLEEKIMDQYKFYDPAPKKKNHWIGAKALVKLIK 1407

  Fly  1141 KAS--------------------SDLMNKVPSRNRRS-------------WVDDARTNSQFV--- 1169
            ...                    ||..:..||:..||             .|::..|::..|   
Mouse  1408 PKKEGSRERLKSTTDSPPWQLEPSDPASPSPSQALRSQTENPDNPPSGPNCVEERDTHNGPVGKG 1472

  Fly  1170 -------IGSESGG--NESDNSNE--------EP----LSIASDTHLLQRNVPLRQSLQR----- 1208
                   .||..||  :.:|.|.:        ||    .|.::.|..|..:.|:.:.|.|     
Mouse  1473 PGDLKPKRGSPRGGSVDRTDTSTDPAVKSWPSEPGSRTFSTSATTAALSSSTPIPKHLGRTKGCN 1537

  Fly  1209 ---DLLDNSIQRGGAVRSSLQAQKRTDLNNSRRNSVHGSLEAP-DVTGSS--------------- 1254
               :|.:.|.:..|..... ||.:...|.:||..|.:.|   | .:.|||               
Mouse  1538 SDDNLCEPSSEPDGPYHRQ-QASRPNSLESSRNASSNSS---PLSLKGSSDHLHSRCESFSSADL 1598

  Fly  1255 ------LTLGTAGSRRTVYLIDEHQKLPDGSTPGATQS-QSVGGSGSVNAAPPTPAEPQTPQKST 1312
                  .||...|:.....|:..|:..|..:.|.:.:: |..|.:.:.....|..|.|.:...:.
Mouse  1599 IPSRDPATLSRDGNTSGRGLLGRHEYPPPRNGPVSQETIQKKGAASTHTGVRPHSASPSSEMVTL 1663

  Fly  1313 E 1313
            |
Mouse  1664 E 1664

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GirdinNP_647780.1 SMC_prok_B 315..1112 CDD:274008 275/1075 (26%)
SynN 884..1006 CDD:294095 36/125 (29%)
Ccdc88cNP_080957.2 HOOK 17..562 CDD:283312 201/560 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 221..251 7/29 (24%)
JAKMIP_CC3 <477..628 CDD:292653 31/150 (21%)
SCP-1 507..1243 CDD:114219 161/750 (21%)
RILP-like <737..841 CDD:304877 13/103 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1002..1036 6/33 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1410..1716 50/259 (19%)
GBA. /evidence=ECO:0000250|UniProtKB:Q9P219 1652..1683 3/13 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1757..1787
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1808..2009
PDZ-binding. /evidence=ECO:0000255 2006..2009
DVL1-binding. /evidence=ECO:0000269|PubMed:14750955 2007..2009
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167831628
Domainoid 1 1.000 322 1.000 Domainoid score I1213
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 406 1.000 Inparanoid score I1871
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D38555at33208
OrthoFinder 1 1.000 - - FOG0002681
OrthoInspector 1 1.000 - - otm43064
orthoMCL 1 0.900 - - OOG6_104888
Panther 1 1.100 - - O PTHR18947
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3090
SonicParanoid 1 1.000 - - X2052
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1211.930

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