Protein Alignment Girdin and CCDC88A

DIOPT Version :10

• Sequence 1: NP_647780.1
• Gene: Girdin / 38385
• FlyBaseID: FBgn0283724
• Length: 1381
• Species: Drosophila melanogaster
• Sequence 2: NP_001352409.1
• Gene: CCDC88A / 55704
• HGNCID: 25523
• Length: 1871
• Species: Homo sapiens
• Alignment Length: 1676
• Identity: 446/1676 - (26%)
• Similarity: 771/1676 - (46%)
• Gaps: 385/1676 - (22%)

  Fly     8 TPMEIDEFVNSSIISWLESCLPRAELLAG-------YTSLLDGHIIHSVWLQIDP--EPQNNPSE 63
            ||: :::|:.|.:::|:::..|   |.||       |.:|:||..::.|.|||:|  |.|....:
Human     7 TPL-LEQFMTSPLVTWVKTFGP---LAAGNGTNLDEYVALVDGVFLNQVMLQINPKLESQRVNKK 67

  Fly    64 LNDLNGKSLSIARAKNFECVVRNLKSFFEEELGQTILV-LPDAFTLGHHPESKNGLEQMKTLLTL 127
            :|  |..||   |..|...:||.:|.:::|.|.|.|:: ||:...:|.:|.|:.|.|::|.||.|
Human    68 VN--NDASL---RMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEEVKKLLLL 127

  Fly   128 LLGAAVQCPNKELFIARIKELDLETQHAIVGLIKQVT-------DSHSLVLTEDSLERLTP--QS 183
            |||.||||..||.||.||:.||.:|:.|:...|::||       |...:.:|:.|.|.:.|  ::
Human   128 LLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKN 192

  Fly   184 MYTHILRLTKERDVMYLKWIDLACVETEMTASDNLVECGQGVSVTRSPSNGTATSTPSSSSNSES 248
            |..|:.||..|||......|:|:      ...|.|.......|..:||     ..:|........
Human   193 MALHLKRLIDERDEHSETIIELS------EERDGLHFLPHASSSAQSP-----CGSPGMKRTESR 246

  Fly   249 NHLAVECADLRSKNRKLRQELEEKSENLLELREELDDKKARFDKLRQESQEWFTEAKRASAYRDE 313
            .||:||.||.::|.|:||||||||:|.||:.::||:..:....:|:||:....::|:.|..||||
Human   247 QHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDE 311

  Fly   314 VDILRERAERADRLEVEVQKYREKLGDSDFYKSRVEELREDNRVLLESKEMLEEQLQRYRKRSEH 378
            :|.|||:|.|.|:||.||.:|:|:|.|.:|||:|||||:|||:||||:|.|||:||:..|.||:.
Human   312 LDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDK 376

  Fly   379 AISLESEIIKYKQKINDMALERDVDRSKLEELLEENSQLQLVAR-NLNSTMDLD---KSFSENED 439
            ...||.|.::.|.|::||.:|||:||.|:|||:|||..|::..: :::.::.|.   :..|...:
Human   377 LHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSE 441

  Fly   440 DCNSGDNSLSEQLTNNAQTRALKLELENRRLTAALEQLKES--SFHESTSKMLELEKEKKKLSLK 502
            ...:...||..::.....:|.||||:||:.||..:|:|:.:  |...:.||:|::|||.::||.|
Human   442 LSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKK 506

  Fly   503 IEQMQENINRLTQQNVELEGVFKNALEENKKLQDAVDNRQKSYDRQ--SLEREAD---------- 555
            :|.::..|.:..|.....:.:.|:.::|..:|:..::..:::.:||  .||:|.:
Human   507 VEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLR 571

  Fly   556 -RQKLSDAEQHVETLNKEKQRIQTLNESIQRRADDLERLAESK---TKELEQYLEKSRQYELTKQ 616
             |.::| ||..|:.:.||.   :.|:|||:..:..|.::...|   .||||.|.||..:.|..:.
Human   572 QRSQIS-AEARVKDIEKEN---KILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELEN 632

  Fly   617 KLYEIE-----------------ARVSTYERENASLLKEVSKLK-------------EGSEQKSV 651
            :|:.:|                 .::...|:||:.|.:|..|||             |..|:::.
Human   633 ELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENS 697

  Fly   652 QLDD-----------------SINRLDVQSKEL-------------------------------- 667
            |||:                 .:.:|.:::|||
Human   698 QLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLD 762

  Fly   668 ---QKLGKALEDS-----------------------------------EQVHQ------------ 682
               |:|.|.||:|                                   ||:.:
Human   763 IENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQL 827

  Fly   683 ------------------------------------------------------KLVELEKQNQE 693
                                                                  :|.||||:|:|
Human   828 EKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKE 892

  Fly   694 LASQRIIDQEMISTLRNDLVTGTLVTKKVRNNLEKLGLADEEPGELNVEHVV-EKLVRNPETFKT 757
            |..:..||.:.:.|||.|||:..|.|:::.|:||||....|:.| ||.|.:: ::...:...:|.
Human   893 LVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIG-LNKERLLHDEQSTDDSRYKL 956

  Fly   758 VREIMLNVTREQLE-EEEREGGVKSDMCVLCH-----RQEIFTVEKNIELAATPAPAPAQPSSQE 816
            :...:.:..::.|| :||:...:::.:....:     |||:.||:||.|..           .|.
Human   957 LESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEAL-----------KQR 1010

  Fly   817 LRFEHKVRLSP---------ARESAELTR------------------------------------ 836
            ...|..|:.||         .|||.|.||
Human  1011 QDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQ 1075

  Fly   837 -----------------IKDSNTQLQTENARLSVDVAALGSQITSLNTQHVALQLANSQLAAEKD 884
                             :::.||.|||:||:|.|:.:.|.||.|||..|:..|.:..|.|..|.:
Human  1076 NNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENE 1140

  Fly   885 SLLKEIDSLQQEHKHALQDQVTLQCLHDQLSAEYESLNKDKEQLKAAVRDLRQELRDTREQQSAL 949
            |::||.:.|:..:...::|...|:.||::.::|||||......||:|.::|..|.||..::.:.|
Human  1141 SVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQL 1205

  Fly   950 EQRIEELTIQNSNMKTCSEDLSILRTEHSKLTDDFRNLFATSDRFKNEYKNIQEQYKMVRMEHSS 1014
            .::..:|......:|...|.:.:....|..:..:::.|...:||..:.|..:.::.::::.:|.:
Human  1206 LKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKN 1270

  Fly  1015 L-------KLQNTELSGELNAKSDQVRCLQMEYSKVQQRCEMLIQNNAELDSERKALMDNVSQLL 1072
            |       ||:.|.|..|.:...:|.:.|.:..:|:..:||:|.|....|:.|.:.|:|.:..|:
Human  1271 LKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLM 1335

  Fly  1073 SQYQELLAISLEDKKHFHEEEKNYTERVHSLKRQKEKLEEKIMEHYKKSETTVHKKK-PFASMLV 1136
            .|.:.||..::|.|..||.|::.|.::::.|:|||||||||||:.||..:.:..::: .:.::.:
Human  1336 LQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKM 1400

  Fly  1137 RRVKKASSDLMNKVPSRNRRSWVDDARTNSQFVIG--------SESGGNESDNSNEEPLSIASDT 1193
            |::.|:..|:     :|.|:..:....|.|....|        |:...:...||.|:..::.:..
Human  1401 RKLIKSKKDI-----NRERQKSLTLTPTRSDSSEGFLQLPHQDSQDSSSVGSNSLEDGQTLGTKK 1460

  Fly  1194 HLL--------QRNVP---------LRQSL-QRDLLDNSIQRGGAVRSSLQAQKRTDLNNSRRNS 1240
            ..:        .||.|         .|:|: ..||:.:.:..|....|:...:...|::..:|..
Human  1461 SSMVALKRLPFLRNRPKDKDKMKACYRRSMSMNDLVQSMVLAGQWTGSTENLEVPDDISTGKRRK 1525

  Fly  1241 VHGSLEAPDVTGSSLTLGTAGSRRTVYLID--EHQKLPDGSTPGATQSQSVGGSGSVNAAPPTPA 1303
            ..|::.......:..|:.::...|:..|::  :.....|.|..|.:...|.|  ..|:|:.|...
Human  1526 ELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKDTTSFEDISPQGVSDDSSTG--SRVHASRPASL 1588

  Fly  1304 EP-QTPQKSTENNAPVGPATFLMYNRINTTIGGASNSGDQSPLLQASGSVS 1353
            :. :|...::.|||           .::....||.|: ...|...:||..|
Human  1589 DSGRTSTSNSNNNA-----------SLHEVKAGAVNN-QSRPQSHSSGEFS 1627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Girdin	NP_647780.1	HkD_HkRP	15..165	CDD:411794	62/166 (37%)
		SMC_prok_B	315..1110	CDD:274008	277/1075 (26%)
CCDC88A	NP_001352409.1	HkD_Girdin	10..165	CDD:411800	61/162 (38%)
		PRK03918	253..890	CDD:235175	174/640 (27%)
		SMC_prok_B	596..1373	CDD:274008	172/788 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	816..842		0/25 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1010..1035		6/24 (25%)
		Phosphoinositide-binding. /evidence=ECO:0000269|PubMed:16139227	1390..1408		2/17 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1407..1459		10/56 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1559..1601		9/43 (21%)
		GBA. /evidence=ECO:0000269|PubMed:30194280	1672..1702
		SH2-like, required for interaction with growth factor receptors. /evidence=ECO:0000269|PubMed:25187647	1713..1823
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1736..1871