Protein Alignment Girdin and ccdc88c

DIOPT Version :9

• Sequence 1: NP_647780.1
• Gene: Girdin / 38385
• FlyBaseID: FBgn0283724
• Length: 1381
• Species: Drosophila melanogaster
• Sequence 2: XP_009291497.1
• Gene: ccdc88c / 553231
• ZFINID: ZDB-GENE-100419-3
• Length: 2000
• Species: Danio rerio
• Alignment Length: 1735
• Identity: 463/1735 - (26%)
• Similarity: 733/1735 - (42%)
• Gaps: 467/1735 - (26%)

  Fly    12 IDEFVNSSIISWLESCLP----RAELLAGYTSLLDGHIIHSVWLQIDPEPQN---NPSELNDLNG 69
            :..|::|.::.|:::..|    ..:.|:.:..|:||..:|.:...|||.|.|   |....||:|
Zfish     9 MSNFMDSPLVVWVKTFGPLGFSSEDKLSMFMDLVDGVFLHKIMTHIDPSPMNQRVNKQVNNDVN- 72

  Fly    70 KSLSIARAKNFECVVRNLKSFFEEELGQTILV-LPDAFTLGHHPESKNGLEQMKTLLTLLLGAAV 133
                 .|.:|...|:|::|::::|.|.|.|:: ||:...:...|.|...:|:||.:|.|:||.||
Zfish    73 -----LRIQNLNTVIRHIKNYYQEHLQQLIVMNLPNVLAIAKDPLSGKSMEEMKRMLLLILGCAV 132

  Fly   134 QCPNKELFIARIKELDLETQHAIVGLIKQVTDSHSLVL-------TEDSLERLTP--QSMYTHIL 189
            ||..||..|.:||.||:|||.|||..|::||.:...||       .|...|:|.|  ::|..|:.
Zfish   133 QCDRKEEIIEKIKLLDIETQAAIVTHIQEVTHNQENVLDLQWMEVAEIPAEQLDPLSRTMAFHLR 197

  Fly   190 RLTKERDVMYLKWIDLACVETEMTASDNLVECGQGVSVTRSPS-NGTATSTPSSSSNSESNHLAV 253
            :|..|||       :.|.:..|:|...:.::..|...:...|| ..|:.|..:..|..:..||||
Zfish   198 KLIDERD-------ESAELVIELTQERDYLQSQQPSGLLGFPSPERTSLSPITLLSKEDRQHLAV 255

  Fly   254 ECADLRSKNRKLRQELEEKSENLLELREELDDKKARFDKLRQESQEWFTEAKRASAYRDEVDILR 318
            |.||.::|.|:.|||||||:|.|::.:.|::...:...||:||:.:...||:...|||||||.||
Zfish   256 ELADTKAKLRRSRQELEEKTEQLIDAKNEIERLDSDIQKLKQENTQLLAEARSVRAYRDEVDSLR 320

  Fly   319 ERAERADRLEVEVQKYREKLGDSDFYKSRVEELREDNRVLLESKEMLEEQLQRYRKRSEHAISLE 383
            |||.:.||||.|:.:::|||.|..|||:|:|||||||..|||:|.||||||...|.|.:....||
Zfish   321 ERAGKVDRLETELSRFKEKLNDVHFYKTRIEELREDNLTLLETKSMLEEQLTGARGRCDKLHELE 385

  Fly   384 SEIIKYKQKINDMALERDVDRSKLEELLEEN-----SQLQLVARNLNSTMDLDKSFSENEDDCNS 443
            .|.::.:.|::|:.::||.|:.:||||||||     ||.|.:..:.:...:|::....||  .|.
Zfish   386 KENLQLRSKLHDIEIDRDSDKKRLEELLEENMLLEISQKQSMNESAHLGWELEQLAKNNE--VNE 448

  Fly   444 GDNSLSEQLTNNAQTRALKLELENRRLTAALEQLKESSFH--ESTSKMLELEKEKKKLSLKIEQM 506
            ...|...:|..:|.:|.||||.||:.|.:.:::|:|:|.:  |.....||||||.:.||.|:|::
Zfish   449 ARKSFVFELNESASSRLLKLEKENQCLQSTIQELREASINMEEGQLHSLELEKENQSLSKKLERL 513

  Fly   507 QENINRLTQQNVELEGVFKNALEENKKLQDAVDNRQKSYDRQSLEREADRQKLSDA--------- 562
            |..:::..|...::|.:.:..::|.::::..::..|...|||..|.|.:::.|:.|
Zfish   514 QSQLDQEKQTTQDMENLGEELIKEKQRMEKTLETIQAEKDRQISELEQEKEHLTQAVSSLRKRAQ 578

  Fly   563 ------EQHVET------------------------------------------LNKEKQRIQTL 579
                  .:.|||                                          |.:|..|::.:
Zfish   579 ANSEARVREVETENRILHQTISETGGKLARLEAEKRQVTKELESLRERGERCEELEREVPRLERV 643

  Fly   580 NESIQR----------RADDLER--------------LAES------------------------ 596
            .|.:||          ||:.|||              ||::
Zfish   644 REQLQREAAALKIGSERAEALERENATLEQDNRRLKKLADTAQNATLRLAVLEKDHQQLEEENLE 708

  Fly   597 ----------------------------------------------------------KTKELEQ 603
                                                                      :.:.|:|
Zfish   709 QRRALETLRPAAARLAQLQQEHAELEREHEEMCRTMEELRSQAKRSERLEKSCGSLSLENQRLQQ 773

  Fly   604 YLEKS----------------------RQYELTKQKL----------YEIEARVSTYERENASLL 636
            .||.|                      |:.|..:||:          ..:|..:|..|:|...|.
Zfish   774 TLENSSTKMQGLESELRQNEAEMKDLQRELEGLRQKVTWAETLEKENRGMEQELSQLEKEKKQLE 838

  Fly   637 KEVSKLKEGSEQKSVQLDDSINRLDVQSKELQKLGKALEDSEQVHQKLVELEKQNQELASQRIID 701
            ||..:.::..|.|...|:::..||....||...|.|.|...::...:|.|||::|::|..|..:|
Zfish   839 KEARRFRQQLEVKEAALEENCLRLASMEKEGTALSKELGRVKEAAGRLKELERENKDLQKQATMD 903

  Fly   702 QEMISTLRNDLVTGTL-------VTKKVRNNLEKLGLADEEPGELNVEHVVE-KLVRNPETFKTV 758
            ::.::|||.:||...|       ..:|:.:.|||:||..|:  .|..||..| |.....:..:|.
Zfish   904 KKTLATLREELVNEKLRVQQQCNELEKLSHELEKIGLNREK--LLQEEHSCEDKCSSKYKILETK 966

  Fly   759 REIMLNVTREQLEEE--------EREGGVKSDMCVLCHRQEIFTVEKNIELAATPAPAPAQPS-- 813
            .|..|..|.|..||:        |....:...:     |.|:.||:||:|.........|..|
Zfish   967 IESALKKTLELREEKIQSLESRLEESSSLNQQL-----RTELTTVKKNLEALKQRHEEEAAHSEI 1026

  Fly   814 -------SQELRFEHKVRLSPARESAELTRIKD-------SNTQLQTE--------------NAR 850
                   ::.|..:.|..:.....:|||.::||       :|..||||              ||:
Zfish  1027 SQQTLGQTRSLPDKEKWEMEQREATAELLKLKDRLIDVEKNNAALQTEKYLLKDQLKQIDSQNAQ 1091

  Fly   851 LSVDVAALGSQI-------TSLNTQHVALQLANSQLAAEKDSLL--------------KEIDSLQ 894
            |:....||..|.       |||:.:...||:.||.|:::..||:              .|.:|||
Zfish  1092 LNAQTLALQKQAASLQEHNTSLHKETAKLQVENSTLSSQSSSLMAQYGALQAQLQTLESEAESLQ 1156

  Fly   895 QEHKHA-------LQDQVTLQCLHDQLSAEYESLNKDKEQLKAAVRDLRQELRDTREQQSALEQR 952
            ::.:.|       .||...|..:|::.::|||.|......|||:.|.|.||.|       .||.:
Zfish  1157 KQREEASAARDRVTQDHERLLGVHERQASEYEQLIAQHAALKASQRALEQENR-------TLENK 1214

  Fly   953 IEELTIQNSNMKTCSEDLSILRTEHSKLTDDFRN---LFATSDRFKNEYKNIQEQYKMVRMEHSS 1014
            ...|..|...|:...|.   |:.:...|.::.|.   :...:...:.|...:...:..:|.|:.|
Zfish  1215 YMVLLKQKDAMEALEES---LQRDRESLGEEIRKNTLILGENRSLREEVDRVSHMHTQLRQEYDS 1276

  Fly  1015 LKLQNTELSGELN----------AKSDQVR----CLQMEYSKVQQRCEMLIQNNAELDSERKALM 1065
            |:||..||...||          |:.||::    .|.:..:|:...||:|.:....|:.|...|:
Zfish  1277 LQLQTKELKTSLNESQLELNRWQARYDQLKEQHQGLDISMTKLDNHCELLTRLKGNLEEENHHLL 1341

  Fly  1066 DNVSQLLSQYQELLAISLEDKKHFHEEEKNYTERVHSLKRQKEKLEEKIMEHYKKSETTVHKKKP 1130
            ..:..|..|.|.||..::|.|:.:|||:|.|.::::||:|||||||||||:.||..:.|..|.:.
Zfish  1342 SQIQMLSQQNQTLLERTMESKELYHEEQKQYIDKLNSLRRQKEKLEEKIMDQYKFYDPTPKKSRQ 1406

  Fly  1131 F--ASMLVR------------------RVKKASSDLMNKVPS------------------RNRRS 1157
            :  |..:.:                  |::.|....:.::|:                  |..|.
Zfish  1407 WVGAKAIAKFIKPKKESSRERPDAPRERIRSAPDIPLPEIPTCIDCPESAPPPPPPPLPPRQSRP 1471

  Fly  1158 WVDDARTNSQFVI-----------------------GSES--------GGNESDNSNEE------ 1185
            .:|.  .|||.|.                       ||.|        ||:||.|..||
Zfish  1472 SLDS--MNSQSVEENHVQSPTLSSPALNGRVLNESGGSRSRDGYRSIGGGSESMNGYEELLRWRS 1534

  Fly  1186 ----------PLS--------IASDTHLLQRNVPLRQSLQRDLLDNSIQRG---------GAVRS 1223
                      |||        ..|.:.|.....|.....:.||..:|...|         |...|
Zfish  1535 REPGGATCSTPLSRNSHNAPGFTSSSSLRPGRRPKGLVSEEDLRHHSPDAGFGSGVHGNTGHRPS 1599

  Fly  1224 SLQAQKRTDLNNSRRNS------VHG---SLEAPDVTGSSLTLGTAGSRRTVYLIDEHQKLPDGS 1279
            |.:..:.|..:||..:|      :.|   ||.:.||.|    |...|||     :.:...||..|
Zfish  1600 SAEFSRNTSSSNSPVSSKGSLDCLQGRSASLSSDDVVG----LAHEGSR-----LSQSSLLPRSS 1655

  Fly  1280 T-PGATQSQSVGGSGSVNAAPPTP-AEPQTPQKSTENNAPVGPAT 1322
            | |..:.|.|.......:..|.:| :|..|.::..:.:..:.|.|
Zfish  1656 TLPCDSPSASRPSQRPASRRPSSPGSEMVTLEEFLQESNALSPPT 1700

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Girdin	NP_647780.1	SMC_prok_B	315..1112	CDD:274008	283/1089 (26%)
		SynN	884..1006	CDD:294095	33/145 (23%)
ccdc88c	XP_009291497.1	SCP-1	317..1058	CDD:114219	188/749 (25%)
		SPEC	473..687	CDD:295325	43/213 (20%)
		RILP-like	<527..626	CDD:304877	13/98 (13%)
		Lipocalin	<908..1067	CDD:304412	42/165 (25%)
		KASH_CCD	1050..1233	CDD:291334	53/192 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574683
Domainoid	1	1.000	329	1.000	Domainoid score	I1139
eggNOG	1	0.900	-	-		E1_KOG4643
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D38555at33208
OrthoFinder	1	1.000	-	-		FOG0002681
OrthoInspector	1	1.000	-	-		otm24826
orthoMCL	1	0.900	-	-		OOG6_104888
Panther	1	1.100	-	-	O	PTHR18947
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3090
SonicParanoid	1	1.000	-	-		X2052
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.740