DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Girdin and HOOK1

DIOPT Version :9

Sequence 1:	NP_647780.1	Gene:	Girdin / 38385	FlyBaseID:	FBgn0283724	Length:	1381	Species:	Drosophila melanogaster
Sequence 2:	NP_056972.1	Gene:	HOOK1 / 51361	HGNCID:	19884	Length:	728	Species:	Homo sapiens

Alignment Length:	732	Identity:	175/732 - (23%)
Similarity:	334/732 - (45%)	Gaps:	105/732 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 SIISWLES------CLPRAELLAGYTSLLDGHIIHSVWLQIDPEPQNNPSELNDLN---GKSLSI 74
            |::.||::      |....:|.:|.......|.|.:.|.        |.|.|:.:.   |.:..|
Human    17 SLMIWLQTFNTASPCQDVKQLTSGVAMAQVLHQIDAAWF--------NESWLSRIKEDVGDNWRI 73

  Fly    75 ARAKNFECVVRNLKSFFEEELGQTI--LVLPDAFTLGHHPESKNGLEQMKTLLTLLLGAAVQCPN 137
             :|.|.:.|::.:.|::.|.|||.|  .::||   |....|..:.:| :..||.|:||.|:.|..
Human    74 -KASNVKKVLQGIMSYYHEFLGQQISEALIPD---LNQITECSDPVE-LGRLLQLILGCAINCEK 133

  Fly   138 KELFIARIKELDLETQHAIVGLIKQVTDSHSLVL-TEDSLERLTPQSMYTHILRLTKERDVMYLK 201
            |:..|..|..|:...||.::..|:::.....|.. ..|::..|..|     :.|..:|......:
Human   134 KQEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQ-----LKRALEELQEALAE 193

  Fly   202 WIDL--ACVETEMTAS------DNLVECGQGVSVTRSPSNGTATSTPSSSSNSESNHLAVECADL 258
            ..:|  .|.|.:|..:      ::||...:.::......:| :...|::....:..|..::...|
Human   194 KEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDG-SFDDPNTVVAKKYFHAQLQLEQL 257

  Fly   259 RSKNRKLRQELEEKSENLLELREELDDKKARFDKLRQESQEWFTEAKRASAYRDEVDILRERAER 323
            :.:|.:|....::...:..||.::|.:.:.|.|:|...::|       ..|.:||:|:||..:::
Human   258 QEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEE-------TRALKDEIDVLRATSDK 315

  Fly   324 ADRLEVEVQKYREKLGDSDFYKSRVEELREDNRVLLESKEMLEEQLQRYRKRSEHAISLESEIIK 388
            |::||..|:.||:||.|.:..:.:|:.|:|.|.:.:.:...|||:|::       |.:..:::..
Human   316 ANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKK-------ANAARTQLET 373

  Fly   389 YKQKIND--------------MALERDVDRSKLEELLEENSQLQLVARNLNSTMDLDKSFSENED 439
            ||:::.|              :|.|......|.|.||:|..:|......|..|.:..:.....:|
Human   374 YKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEELRCSQVQQD 438

  Fly   440 DCNSGDNSLSEQLTNNAQTRALKLELENRRLTAALEQLKESSFHESTSKMLELEKEKKKLSLKIE 504
            ..|..|.|.::...|.|   |..:.:|.|.:...|:       ||  :|||.|::|..: :.:||
Human   439 HLNQTDASATKSYENLA---AEIMPVEYREVFIRLQ-------HE--NKMLRLQQEGSE-NERIE 490

  Fly   505 QMQENINRLTQQNVELEGVFKNALEENKKLQDAVDNRQKSYDRQSLEREAD-----RQKLSDAEQ 564
            ::||.:.:..::..|||...:.:.|..::||..:::.|||...|..:.|.:     :|||   |.
Human   491 ELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEGESSSKLKQKL---EA 552

  Fly   565 HVETLNKEKQRIQTLNESIQRRADDLERLAESKTKELEQYLEKSRQYELTKQKLYEIEARVSTYE 629
            |:|.|.:..:.:|...|.|:....|:.:..: |..|||..|:|.      .:.:..:|.|...|.
Human   553 HMEKLTEVHEELQKKQELIEDLQPDINQNVQ-KINELEAALQKK------DEDMKAMEERYKMYL 610

  Fly   630 RENASLLKEVS-KLKEGSEQKSV---QLDDSINRLDVQSKELQKLGKALEDSEQVHQKLVELEKQ 690
            .:..:::|.:. ||...|.:..:   ||.:...|:::...|. |:.| ..|.|   :||:.....
Human   611 EKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIEILESEC-KVAK-FRDYE---EKLIVSAWY 670

  Fly   691 NQELASQRI-IDQEMIS 706
            |:.||.|:: ::..::|
Human   671 NKSLAFQKLGMESRLVS 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Girdin	NP_647780.1	SMC_prok_B	315..1112	CDD:274008	105/416 (25%)
Girdin	NP_647780.1	SynN	884..1006	CDD:294095
HOOK1	NP_056972.1	Sufficient for interaction with microtubules	1..555		141/586 (24%)
		HOOK	15..720	CDD:310310	175/732 (24%)
		Sufficient for homodimerization, interaction wit HOOK2, HOOK3 and AP4M1. /evidence=ECO:0000269\|PubMed:32073997	169..444		63/294 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	481..512		8/31 (26%)
		Sufficient for interaction with AKTIP and VPS18. /evidence=ECO:0000269\|PubMed:18799622	657..728		9/34 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141677
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840