DRSC/TRiP Functional Genomics Resources

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Protein Alignment Girdin and CCDC88C

DIOPT Version :9

Sequence 1:NP_647780.1 Gene:Girdin / 38385 FlyBaseID:FBgn0283724 Length:1381 Species:Drosophila melanogaster
Sequence 2:NP_001073883.2 Gene:CCDC88C / 440193 HGNCID:19967 Length:2028 Species:Homo sapiens


Alignment Length:1645 Identity:441/1645 - (26%)
Similarity:725/1645 - (44%) Gaps:405/1645 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 IDEFVNSSIISWLESCLP----RAELLAGYTSLLDGHIIHSVWLQIDPEPQN---NPSELNDLNG 69
            ::.|:.|.:::|:::..|    ..:.|..|..|:||..::.:.|||||.|.|   |....||:| 
Human     9 LELFLQSPLVTWVKTFGPFGSGSQDNLTMYMDLVDGIFLNQIMLQIDPRPTNQRINKHVNNDVN- 72

  Fly    70 KSLSIARAKNFECVVRNLKSFFEEELGQTILV-LPDAFTLGHHPESKNGLEQMKTLLTLLLGAAV 133
                 .|.:|...:|||:|::::|.|.|.|:: ||:...:|..|.|...:|::|.:|.|:||.||
Human    73 -----LRIQNLTILVRNIKTYYQEVLQQLIVMNLPNVLMIGRDPLSGKSMEEIKKVLLLVLGCAV 132

  Fly   134 QCPNKELFIARIKELDLETQHAIVGLIKQVTDSHSLV----------LTEDSLERLTPQSMYTHI 188
            ||..||.||.|||:||:|||..||..|::||.:...|          :..:.||.|: :||..|:
Human   133 QCERKEEFIERIKQLDIETQAGIVAHIQEVTHNQENVFDLQWLELPDVAPEELEALS-RSMVLHL 196

  Fly   189 LRLTKERDVMYLKWIDLACVE--TEMTASDNLVECGQGVSVTRSPSNGTATSTPSSSSNSESNHL 251
            .||..:||         .|.|  .::|...:.::.....|..:|.|..:..|..||.|:.:..||
Human   197 RRLIDQRD---------ECTELIVDLTQERDYLQAQHPPSPIKSSSADSTPSPTSSLSSEDKQHL 252

  Fly   252 AVECADLRSKNRKLRQELEEKSENLLELREELDDKKARFDKLRQESQEWFTEAKRASAYRDEVDI 316
            |||.||.:::.|::|||||:|:|.|::.|.|:|.......|::||:.:...:|:.|.|||||:|.
Human   253 AVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSARAYRDELDS 317

  Fly   317 LRERAERADRLEVEVQKYREKLGDSDFYKSRVEELREDNRVLLESKEMLEEQLQRYRKRSEHAIS 381
            |||:|.|.:|||:|:.:.:|||.|.||||:|:|||||||.:|:|:|.||||||...|.|.:....
Human   318 LREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVHE 382

  Fly   382 LESEIIKYKQKINDMALERDVDRSKLEELLEENSQLQLVAR-NLNSTMDLD---KSFSENEDDCN 442
            ||.|.::.|.|::|:.|:||.|:.::|||||||..|::..: ::|.:..|.   :..|:|.|..:
Human   383 LEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSD 447

  Fly   443 SGDNSLSEQLTNNAQTRALKLELENRRLTAALEQLKESS--FHESTSKMLELEKEKKKLSLKIEQ 505
            :...|...:|...|.:|.||||.||:.|.:.::.|:::|  ..||..|..|||||..:||.|||:
Human   448 ASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEK 512

  Fly   506 MQENINRLTQQNVELEGVFKNALEENKKLQDAVD--------------------NR--------- 541
            :|..:.|..|.|.:||.:.:..:.|.::||..::                    ||         
Human   513 LQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERS 577

  Fly   542 ------------------------------QKSYDRQSLEREADRQK------------------ 558
                                          |..::::.|.|:.::.|                  
Human   578 QVSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQE 642

  Fly   559 -----------LSDAEQHVETLNKEKQRIQTLNESIQRRAD------------------------ 588
                       |..|.:.||.|..|.|.:|..|.::::..|                        
Human   643 ENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENL 707

  Fly   589 DLERLAE------SKTKELE---QYLE------------------KSRQYELTKQ---------- 616
            :|.||.|      :|..::|   |.||                  ||.:.||:.|          
Human   708 ELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQ 772

  Fly   617 ---------------KLYEIEA-------------------------------RVSTYERENASL 635
                           :|.|:||                               .|:..|::...|
Human   773 QSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLL 837

  Fly   636 LKEVSKLKEGSEQKSVQLDDSINRLDVQSKELQKLGKALEDSEQVHQKLVELEKQNQELASQRII 700
            .||..:|.:..|.|...||||..:|....||.:.|.|.|........||.||||.|::|..|..:
Human   838 EKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTV 902

  Fly   701 DQEMISTLRNDLVTGTLVTKKVRNNLEKLGLADEEPGELNVEHVVE----------KLV--RNPE 753
            ....::|||.|||...|.::::.:.|:||....|:.| ||.|.:::          |::  ||..
Human   903 HARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVG-LNRELLLQEDDSGSDTKYKILEGRNES 966

  Fly   754 TFKT---VREIMLNVTREQLEEE---EREGGVKSDMCVLCHRQEIFTVEKNIELAATPAPAPAQP 812
            ..||   ::|..:.:...|:||:   .|:  ::|::.:|  ::|..|:.:|            |.
Human   967 ALKTTLAMKEEKIVLLEAQMEEKASLNRQ--LESELQML--KKECETLRQN------------QG 1015

  Fly   813 SSQELR--FEH-----------KVRLSPARESA--ELTRIKD----------------------- 839
            ..|.|:  |:|           |....|..:.|  ||.|:||                       
Human  1016 EGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQL 1080

  Fly   840 --------------------------SNTQLQTENARLSVDVAALGSQITSLNTQHVALQLANSQ 878
                                      .||.|||:.|:|.|:.:.|.||..:|..|:..||..::.
Human  1081 QHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTA 1145

  Fly   879 LAAEKDSLLKEIDSLQQEHKHALQDQVTLQCLHDQLSAEYESLNKDKEQLKAAVRDLRQELR--- 940
            ...|.:||.::.:.|...::..|||...|..||::.|||||:|.:....||...|:|..|.:   
Human  1146 KETENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELG 1210

  Fly   941 ----DTREQQSALEQRIEELTIQNSNMKTCSEDLSILRTEHSKLTDDFRNLFATSDRFKNEYKNI 1001
                |..::::.||:|.:.||.:...::......::...|:.:|..:...:.....:.|.||:.:
Human  1211 ERHGDMLKRKAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEYEEL 1275

  Fly  1002 QEQYKMVRMEHSSLKLQNTELSGELNAKSDQVRCLQMEYSKVQQRCEMLIQNNAELDSERKALMD 1066
            ....|.::...::.:|:........:...:|.:.:.:..:|:...||:|.:....|:.|...|:.
Human  1276 HAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEENHHLLS 1340

  Fly  1067 NVSQLLSQYQELLAISLEDKKHFHEEEKNYTERVHSLKRQKEKLEEKIMEHYKKSETTVHKKKPF 1131
            .:..|..|.|.||..::|:|:.:|||:|.|.:::::|:|.|||||||||:.||..:....||..:
Human  1341 QIQLLSQQNQMLLEQNMENKEQYHEEQKQYIDKLNALRRHKEKLEEKIMDQYKFYDPPPKKKNHW 1405

  Fly  1132 --ASMLVRRVKKASSDLMNKVPSRNR-RSWVDDARTNSQFVIGSESGGNESDNSNEEPLSIAS-- 1191
              |..||:.:|.      .|..||.| :|.||.....      .||....|..:::...|.|.  
Human  1406 IGAKALVKLIKP------KKEGSRERLKSTVDSPPWQ------LESSDPASPAASQPLRSQAENP 1458

  Fly  1192 DTHLLQRNVPLRQSLQRDLLDNSIQRGGAVRSSLQAQKRTDLNNSRRNSVHGSLEAPDVT----- 1251
            ||..|..|.    :.:||..:.|:.:|..           ||...|.:...|||:..|.:     
Human  1459 DTPALGSNC----AEERDAHNGSVGKGPG-----------DLKPKRGSPHRGSLDRTDASTDLAM 1508

  Fly  1252 ---GSSLTLGTAGSRRTVYLIDEHQKLPDGSTPGATQ-SQSVGGSGSVNAAPPT----------- 1301
               .|.|...|..:..|.       ..|..|||.|.. .::.|.:...|...|:           
Human  1509 RSWPSELGSRTCSTSATT-------TAPSNSTPIARHPGRTKGYNSDDNLCEPSLEFEVPNHRQY 1566

  Fly  1302 ---PAEPQTPQKSTENNAPV 1318
               |:..::.:.::.|::|:
Human  1567 VSRPSSLESSRNTSSNSSPL 1586

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GirdinNP_647780.1 SMC_prok_B 315..1112 CDD:274008 274/1086 (25%)
SynN 884..1006 CDD:294095 31/128 (24%)
CCDC88CNP_001073883.2 HOOK 17..633 CDD:283312 211/631 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 222..250 7/27 (26%)
Myosin_tail_1 329..1319 CDD:279860 242/1006 (24%)
RILP-like <489..601 CDD:304877 24/111 (22%)
DUF2570 664..>741 CDD:305162 15/76 (20%)
RILP-like <755..868 CDD:304877 20/112 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1011..1043 7/43 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1419..1724 42/196 (21%)
GBA. /evidence=ECO:0000269|PubMed:30194280 1661..1691
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1736..1803
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1816..2021
PDZ-binding. /evidence=ECO:0000255 2025..2028
DVL1-binding. /evidence=ECO:0000250|UniProtKB:Q6VGS5 2026..2028
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165141678
Domainoid 1 1.000 337 1.000 Domainoid score I1116
eggNOG 1 0.900 - - E1_KOG4643
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 410 1.000 Inparanoid score I1872
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D38555at33208
OrthoFinder 1 1.000 - - FOG0002681
OrthoInspector 1 1.000 - - otm40993
orthoMCL 1 0.900 - - OOG6_104888
Panther 1 1.100 - - O PTHR18947
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3090
SonicParanoid 1 1.000 - - X2052
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.790

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