DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Girdin and hook2

DIOPT Version :9

Sequence 1:	NP_647780.1	Gene:	Girdin / 38385	FlyBaseID:	FBgn0283724	Length:	1381	Species:	Drosophila melanogaster
Sequence 2:	NP_957405.1	Gene:	hook2 / 394086	ZFINID:	ZDB-GENE-040426-1636	Length:	476	Species:	Danio rerio

Alignment Length:	479	Identity:	101/479 - (21%)
Similarity:	196/479 - (40%)	Gaps:	92/479 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   280 REELDDKKARFDKLRQESQEWFTEAKRASAYRDEVDILRERAERADR-LEVEVQKYREKLGD--S 341
            :.||....|....|.:....||.|...:....|.....|.:.....: |:..::.|.:.|..  |
Zfish    27 KHELTSGVAIAHVLNKIDSTWFNETWLSRIKEDGGTNWRLKVSNLKKILQSMMEYYHDVLSQQVS 91

  Fly   342 DFYKSRVEELREDNRVLLESKEMLEEQLQRYRKRSEHAISLESEIIKYKQKINDMALERDVDRSK 406
            |.:...|..|.|.|.|.::....|||:.:|       |.::.|::..||::.::|:.:...:..|
Zfish    92 DEHVPDVRLLEERNHVYMQRTCELEEEQRR-------ATAIRSQLDSYKRQAHEMSAKHSAEAMK 149

  Fly   407 LEELLEENSQLQLVARNLNSTMDL-----DKSFSENE-------------------DDCNSGD-- 445
            .|       :.|...:|||...:.     :|..||.:                   .|...||
Zfish   150 AE-------KWQFEYKNLNDKYETLLKEREKLISERDTLRETTEELRCAQVQQQCLTDSMIGDAG 207

  Fly   446 --NSL-SEQLTNNAQTRALKLELENRRLTA-------ALEQLKESSFHESTSKMLELEKEKK--- 497
              .|| ||.:....:...::|:.||:.|..       .||:| ::...|:..:...||.:.:
Zfish   208 AVGSLASEIMPTEFRDTVVRLQQENKMLCVQEESYRHRLEEL-QTQLEEAQRRQNTLETQNRLSQ 271

  Fly   498 ----KLSLKIEQMQENINRLTQQNVE-LEGVFKNALEEN-KKLQDAVDNRQKSYDRQSLEREADR 556
                .||.::|::|..:.....:|.: :..:.|..|||: :||.:|..:.||.           |
Zfish   272 QQISDLSAQVEELQRALQEQDSRNEDVISSLLKKKLEEHLEKLHEAHSDLQKK-----------R 325

  Fly   557 QKLSDAEQHVETLNKEKQRIQTLNESIQRRADDLERLAESKTKELEQYLEKSRQYELT---KQKL 618
            :.:.|.|..:: :|..| ::..|.|.::::.:|:.|:.:    ..::|:||:|....|   ||||
Zfish   326 EVIDDLEPPLD-INMAK-KVDELQEILKKKDEDMRRMED----RYKRYVEKARTVIKTLEPKQKL 384

  Fly   619 YEIEARVSTYERENASLLKEVSKLKEGSEQKSVQLDDSINRLDVQSKELQKLGKALEDSEQVHQK 683
            ..:...|...:.:.:...:::..|:...| |:....|...:|.:.:  ...:|.||      ||:
Zfish   385 NPVPVEVQALKNQLSEKDRKIQHLEHDFE-KTRSRHDQEEKLIISA--WYNMGMAL------HQR 440

  Fly   684 LVELEKQNQELASQRIIDQEMIST 707
            :......:...::|..:.|:..||
Zfish   441 VAGERSSSSSSSAQSFLAQQRQST 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Girdin	NP_647780.1	SMC_prok_B	315..1112	CDD:274008	93/444 (21%)
Girdin	NP_647780.1	SynN	884..1006	CDD:294095
hook2	NP_957405.1	Lebercilin	244..398	CDD:292252	39/171 (23%)
hook2	NP_957405.1	Prefoldin	248..353	CDD:298833	25/118 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574686
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840