DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Girdin and Ccdc88a

DIOPT Version :9

Sequence 1:	NP_647780.1	Gene:	Girdin / 38385	FlyBaseID:	FBgn0283724	Length:	1381	Species:	Drosophila melanogaster
Sequence 2:	XP_038948817.1	Gene:	Ccdc88a / 305605	RGDID:	1306694	Length:	2016	Species:	Rattus norvegicus

Alignment Length:	1693	Identity:	445/1693 - (26%)
Similarity:	776/1693 - (45%)	Gaps:	407/1693 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 TPMEIDEFVNSSIISWLESCLPRAELLAG-------YTSLLDGHIIHSVWLQIDPEPQNNPSELN 65
            ||: :::|:.|.:::|:::..|   |.||       |.:|:||..::.|.|||:|:.::......
  Rat     7 TPL-LEQFMTSPLVTWVKTFGP---LAAGNGTNLDEYVALVDGVFLNQVMLQINPKTESQRVNKK 67

  Fly    66 DLNGKSLSIARAKNFECVVRNLKSFFEEELGQTILV-LPDAFTLGHHPESKNGLEQMKTLLTLLL 129
            ..|..||   |..|...:|:.:|.::::.|.|.|:: ||:...:|.:|.|:.|.|::|.||.|||
  Rat    68 VNNDASL---RIHNLSILVKQIKFYYQDTLQQLIMMSLPNILVIGKNPFSEQGTEEVKKLLLLLL 129

  Fly   130 GAAVQCPNKELFIARIKELDLETQHAIVGLIKQVT-------DSHSLVLTEDSLERLTP--QSMY 185
            |.||||..||.||.:|:.||.:|:.|:...|::||       |...:.:|:.|.|...|  :||.
  Rat   130 GCAVQCQKKEEFIEKIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDTEPLLKSMA 194

  Fly   186 THILRLTKERDVMYLKWIDLACVETEMTASDNLVECGQ---GV-------SVTRSPSNGTATSTP 240
            :|:.||..|||                ..|:.::|..:   ||       |..:||     ..:|
  Rat   195 SHLRRLIDERD----------------EHSETIIELSEERDGVHFLPHASSSAQSP-----CGSP 238

  Fly   241 SSSSNSESNHLAVECADLRSKNRKLRQELEEKSENLLELREELDDKKARFDKLRQESQEWFTEAK 305
            .........||:||.||.::|.|:||||||||:|.||:.::||:..:....:|:||:....::|:
  Rat   239 GMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEVELKRLQQENMNLLSDAR 303

  Fly   306 RASAYRDEVDILRERAERADRLEVEVQKYREKLGDSDFYKSRVEELREDNRVLLESKEMLEEQLQ 370
            .|..||||:|.|||:|.|.|:||.|:.:|:|:|.|.:|||:|||||:|||:||||:|.|||:||:
  Rat   304 SARMYRDELDALREKAVRVDKLESELCRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLE 368

  Fly   371 RYRKRSEHAISLESEIIKYKQKINDMALERDVDRSKLEELLEENSQLQLVAR-NLNSTMDLD--- 431
            ..|.||:....||.|.::.|.|::||.:|||:||.|:|||:|||..|::..: :::.::.|.
  Rat   369 GTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWEL 433

  Fly   432 KSFSENEDDCNSGDNSLSEQLTNNAQTRALKLELENRRLTAALEQLKES--SFHESTSKMLELEK 494
            :..|...:...:...||..::.....::.||||:||:.||..:|:|:.:  |...||||:|::||
  Rat   434 EQISRTSELAEAPQKSLGHEVNELTSSKLLKLEMENQSLTKTVEELRSTMDSAEGSTSKILKVEK 498

  Fly   495 EKKKLSLKIEQMQENINRLTQQNVELEGVFKNALEENKKLQDAVDNRQKSYDRQ--SLEREAD-- 555
            |.::||.|:|.::..|.:..|.....:.:.|:.::|..:|:..::..:::.:||  .||:|.:
  Rat   499 ENQRLSKKVEILENEIIQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHL 563

  Fly   556 ---------RQKLSDAEQHVETLNKEKQRIQTLNESIQRRADDLERLAESK---TKELEQYLEKS 608
                     |.::| ||..|:.:.||.   :.|:|||:..:..|.::...|   .||||.|.||.
  Rat   564 NQTVSSLRQRSQIS-AEARVKDIEKEN---KILHESIKETSGKLSKIEFEKRQMKKELELYKEKG 624

  Fly   609 RQYE------------------------LTKQKLYEIEARVSTYERENASLLKEVSKLK------ 643
            .:.|                        :|.:||..:|...|..||||....|.:...|
  Rat   625 ERAEELENELNRLGKENELLQKKITNLKITCEKLETLEQENSELERENRKFKKTLDSFKNLTFQL 689

  Fly   644 EGSEQKSVQLDD-----------------SINRLDVQSKEL------------------------ 667
            |..|:::.|||:                 .:.:|.:::|||
  Rat   690 ESLEKENSQLDEENLELRRSVESLKCASMKMAQLQLENKELESEKEQLKKGLELMKASFKKTERL 754

  Fly   668 -----------QKLGKALEDS-----------------------------------EQVHQ---- 682
                       |:|.||||:|                                   ||:.:
  Rat   755 EVSYQGLDTENQRLQKALENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKS 819

  Fly   683 --------------------------------------------------------------KLV 685
                                                                          :|.
  Rat   820 LEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLFKEISVYKESCVRLK 884

  Fly   686 ELEKQNQELASQRIIDQEMISTLRNDLVTGTLVTKKVRNNLEKLGLADEEPGELNVEHVV-EKLV 749
            ||||:|:||..:..||.:.:.|||.|||:..|.|:::.|:||||....|:.| ||.|.:: ::..
  Rat   885 ELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIG-LNKERLLQDEQS 948

  Fly   750 RNPETFKTVREIMLNVTREQLE-EEEREGGVKSDMCVLCH-----RQEIFTVEKNIELAATPAPA 808
            .:...:|.:...:.:..::.|| :||:...:::.:....:     |.|:.||:||.|       |
  Rat   949 TDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRHELKTVKKNYE-------A 1006

  Fly   809 PAQPSSQELRFEHKVRLSP-----ARESAELTR-------------------------------- 836
            ..|...:|...:..:.:|.     .|||.|.||
  Rat  1007 LKQRQDEERMVQSSLPISGEDDKWGRESQEATRELLKVKDRLIEVERNNATLQAEKQALKTQLKQ 1071

  Fly   837 ---------------------IKDSNTQLQTENARLSVDVAALGSQITSLNTQHVALQLANSQLA 880
                                 :::.||.|||:||:|.|:.:.|.||.|||..|:..|.:..|.|.
  Rat  1072 LETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLE 1136

  Fly   881 AEKDSLLKEIDSLQQEHKHALQDQVTLQCLHDQLSAEYESLNKDKEQLKAAVRDLRQELRDTREQ 945
            .|.:|::||.:.|:..:...::|...|:.||::.::|||||......||:|.::|..|.:|..::
  Rat  1137 NENESIMKEREDLKSLYDALIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHKDLEDR 1201

  Fly   946 QSALEQRIEELTIQNSNMKTCSEDLSILRTEHSKLTDDFRNLFATSDRFKNEYKNIQEQYKMVRM 1010
            .:.|.::..:|......:|...|.:.:....|..:..:::.|...:||..:.|..:.::.::::.
  Rat  1202 YNQLLKQKGQLEDLEKMIKVEQEKMLLESKNHEMVAAEYKKLCGDNDRLNHTYSQLLKETEILQT 1266

  Fly  1011 EHSSL-------KLQNTELSGELNAKSDQVRCLQMEYSKVQQRCEMLIQNNAELDSERKALMDNV 1068
            :|.:|       ||:.|.|..|.:...:|.:.|.:..:|:..:||:|.|....|:.|.:.|:|.:
  Rat  1267 DHKNLKSVLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQI 1331

  Fly  1069 SQLLSQYQELLAISLEDKKHFHEEEKNYTERVHSLKRQKEKLEEKIMEHYKKSETTVHKKK-PFA 1132
            ..|:.|.:.||..::|.|..||.|::.|.::::.|:|||||||||||:.||..:.:..::: .:.
  Rat  1332 QTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWI 1396

  Fly  1133 SMLVRRVKKASSDLMNKVPSRNRRSWVDDARTNSQFVIG--------SESGGNESDNSNEEPLSI 1189
            ::.:|::.|:..|:     :|.|:..:....|.|....|        |:...:...||.|:..::
  Rat  1397 TLKMRKLIKSKKDI-----NRERQKSLTLTPTRSDSSEGFLQLPHQDSQDSSSVGSNSLEDGQTL 1456

  Fly  1190 ASDTHLL--------QRNVP---------LRQSL-QRDLLDNSIQRGGAVRSSLQ-AQKRTDLNN 1235
            .:....:        .||.|         .|:|: ..||:.:.:..||....|.: .:...|::.
  Rat  1457 GTKKSSMVALKRLPFLRNRPKDKDKMKACYRRSMSMNDLVQSMVLAGGQWTGSTENLEVPDDIST 1521

  Fly  1236 SRRNSVHGSLEAPDVTGSSLTLGTAGSRRTVYLID--EHQKLPDGSTPGATQSQSVGGSGSVNAA 1298
            .:|....|::.......:..|:.::.:.|:..|::  :.....|.|..|.:...|.|  ..|:|:
  Rat  1522 GKRRKELGAMAFSTTAINFSTVNSSAAFRSKQLVNNKDTTSFEDVSPQGISDDSSTG--SRVHAS 1584

  Fly  1299 PPTPAEP-QTPQKSTENNAPVGPATFLMYNRINTTIGGASN---------SGDQSPL-----LQA 1348
            .|...:. :|...::.|||           .::....||:|         |||.|.|     ..:
  Rat  1585 RPASLDSGRTSTSNSNNNA-----------SLHEVKAGAANIQSRPQSHSSGDFSLLHDHETWSS 1638

  Fly  1349 SGS 1351
            |||
  Rat  1639 SGS 1641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Girdin	NP_647780.1	SMC_prok_B	315..1112	CDD:274008	278/1073 (26%)
Girdin	NP_647780.1	SynN	884..1006	CDD:294095	28/121 (23%)
Ccdc88a	XP_038948817.1	HkD_Girdin	10..165	CDD:411800	55/160 (34%)
		PRK03918	<249..685	CDD:235175	156/439 (36%)
		Smc	474..1331	CDD:224117	191/868 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335365
Domainoid	1	1.000	210	1.000	Domainoid score	I2723
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	415	1.000	Inparanoid score	I1771
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D38555at33208
OrthoFinder	1	1.000	-	-		FOG0002681
OrthoInspector	1	1.000	-	-		otm45128
orthoMCL	1	0.900	-	-		OOG6_104888
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2052
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.800