DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Girdin and HOOK2

DIOPT Version :9

Sequence 1:	NP_647780.1	Gene:	Girdin / 38385	FlyBaseID:	FBgn0283724	Length:	1381	Species:	Drosophila melanogaster
Sequence 2:	NP_037444.2	Gene:	HOOK2 / 29911	HGNCID:	19885	Length:	719	Species:	Homo sapiens

Alignment Length:	798	Identity:	178/798 - (22%)
Similarity:	323/798 - (40%)	Gaps:	154/798 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 MEIDEF-VNSSIISWLES------CLPRAELLAGYT-----SLLDGHIIHSVWLQ---IDPEPQN 59
            |.:|:. :..|:::||::      |....:|.:|..     :.:|....:..|||   .||.|
Human     1 MSVDKAELCGSLLTWLQTFHVPSPCASPQDLSSGLAVAYVLNQIDPSWFNEAWLQGISEDPGP-- 63

  Fly    60 NPSELNDLNGKSLSIARAKNFECVVRNLKSFFEEELGQTILV--LPDAFTLGHHPESKNGLEQMK 122
                    |.|    .:..|.:.|:|:|..:.::.|...:..  |||...:|...:.    .::.
Human    64 --------NWK----LKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIGEFSDP----AELG 112

  Fly   123 TLLTLLLGAAVQCPNKELFIARIKELDLETQHAIVGLIKQVTDSHSLVLTEDSLERLTPQS---- 183
            .||.|:||.|:.|..|:..|.||..|:...||.::..|::       ::|:|:.:.|:|::
Human   113 KLLQLVLGCAISCEKKQDHIQRIMTLEESVQHVVMEAIQE-------LMTKDTPDSLSPETYGNF 170

  Fly   184 -----MYTHILRLTKERDVMYLKWID------LACVETEMTASDNLVECGQGVSVTRSPSNGTAT 237
                 .|..:....:|.|.:..:.:|      |...|.:..|.:|   .|....:.|....||..
Human   171 DSQSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQEN---AGLRERMGRPEGEGTPG 232

  Fly   238 STPSSSSNSESNHLAVECADLRSKNRKLRQELEEKSENLLELREELDDKKARFDKLRQE------ 296
            .|                   ..|...|:.:||:..|....|....:|::.|..:|.:|
Human   233 LT-------------------AKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQH 278

  Fly   297 -SQEWFTEAKRASAYRDEVDILRERAERADRLEVEVQKYREKLGDSDFYKSRVEELREDNRVLLE 360
             :|...:.|:.|.|.:||:|.||:.:|||.:||..:...|.:||:....:.:|.:|.|.|....|
Human   279 RNQALTSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAE 343

  Fly   361 SKEMLEEQLQR------------------YRKRSEHAISLES---EIIKYKQKINDMALERD--- 401
            ....||::|:|                  ..:|.|.|:..|.   |....::|...:..|::
Human   344 RTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLL 408

  Fly   402 VDRSKLEELLEENSQLQLVARNLNSTMDLDKSFSENEDDCNSGDNSLSEQLTNNAQTRALKLELE 466
            .:|..|.|..||....||..|.|...   |.|........   ||..:|.|....:...|:|:||
Human   409 AERDSLREANEELRCAQLQPRGLTQA---DPSLDPTSTPV---DNLAAEILPAELRETLLRLQLE 467

  Fly   467 NRRLTAALEQLKESSFHESTSKMLELEKEKKKLSLKIEQMQENINRLTQQNVELEGVFKNALEEN 531
            |:||  ..::..:....|...:.|| :..:.:..|: .|.:.|..:|::...::|.:.|...|:.
Human   468 NKRL--CRQEAADRERQEELQRHLE-DANRARHGLE-TQHRLNQQQLSELRAQVEDLQKALQEQG 528

  Fly   532 KKLQDAVDNRQKSYDRQSLER--EADRQKLSDAEQHVETL-----NKEKQRIQTLNESIQRRADD 589
            .|.:||:....|....:.|::  |||.: |....:::|.|     :...:||:.|..::|::..|
Human   529 GKTEDAISILLKRKLEEHLQKLHEADLE-LQRKREYIEELEPPTDSSTARRIEELQHNLQKKDAD 592

  Fly   590 LERLAESKTKELEQYLEKSRQYELTKQKLYEIEARVSTYERENASLLKEVSKLKEGSEQKSVQLD 654
            |..:.|    ...:|::|:|....|          :...:|..|....|:..|:....::.|:
Human   593 LRAMEE----RYRRYVDKARMVMQT----------MEPKQRPAAGAPPELHSLRTQLRERDVR-- 641

  Fly   655 DSINRLDVQSKELQKLGKALEDSEQVHQKLVELEKQNQELA-SQRIIDQEMISTLRNDLVTGTLV 718
              |..|::..:      |:....|| .:||:.....|..:| .||..::...:..::.|....|.
Human   642 --IRHLEMDFE------KSRSQREQ-EEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLA 697

  Fly   719 TKKVRNNLEKLGLADEEP 736
            |...|..|.:|...:..|
Human   698 TNSRRGPLGRLASLNLRP 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Girdin	NP_647780.1	SMC_prok_B	315..1112	CDD:274008	104/454 (23%)
Girdin	NP_647780.1	SynN	884..1006	CDD:294095
HOOK2	NP_037444.2	Sufficient for interaction with microtubules	1..548		137/603 (23%)
		Required for localization to the centrosome and induction of aggresome formation	1..161		43/184 (23%)
		HOOK	8..706	CDD:283312	173/780 (22%)
		Required for localization to the centrosome and induction of aggresome formation	533..719		44/209 (21%)
		Sufficient for interaction with CNTRL. /evidence=ECO:0000269\|PubMed:17140400	584..719		31/157 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	696..719		6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141680
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840