Protein Alignment Girdin and CCDC88B

DIOPT Version :9

• Sequence 1: NP_647780.1
• Gene: Girdin / 38385
• FlyBaseID: FBgn0283724
• Length: 1381
• Species: Drosophila melanogaster
• Sequence 2: XP_011543259.1
• Gene: CCDC88B / 283234
• HGNCID: 26757
• Length: 1639
• Species: Homo sapiens
• Alignment Length: 1776
• Identity: 395/1776 - (22%)
• Similarity: 638/1776 - (35%)
• Gaps: 587/1776 - (33%)

  Fly    14 EFVNSSIISW---LESCLPRAELLAG----------------YTSLLDGHIIHSVWLQIDPEPQN 59
            :|::.|:.:|   |...:..||...|                :..|.||.::..|...|.|..:.
Human    11 DFLSGSLATWALGLAGLVGEAEDSEGEEEEEEEEPPLWLEKRFLRLSDGALLLRVLGIIAPSSRG 75

  Fly    60 NPSELNDLNGKSLSIARAKNFECVVRNLKSFFEEELGQTILVL---PDAFTLGHHPESKNGLEQM 121
            .|..|..|:|.  :..|..|...:...|:.|::|||  .:|:|   ||..|||..|.|:..:||:
Human    76 GPRMLRGLDGP--AAWRVWNLNHLWGRLRDFYQEEL--QLLILSPPPDLQTLGFDPLSEEAVEQL 136

  Fly   122 KTLLTLLLGAAVQCPNKELFIARIKELDLETQHAIVGLIKQVTDSHSLV-----------LTEDS 175
            :.:|.|||||:|||.::||||..|:.|.||.|..:...|::||...:.|           |....
Human   137 EGVLRLLLGASVQCEHRELFIRHIQGLSLEVQSELAAAIQEVTQPGAGVVLALSGPDPGELAPAE 201

  Fly   176 LERLTPQSMYTHILRLTKERDVMYLKWIDLACVETEMTASDNLVE----CGQGVSVTRSPSNGTA 236
            ||.|:...|.| :.:|.:|||:...:..:|            |:|    |.:..:.:|:|:.|
Human   202 LEMLSRSLMGT-LSKLARERDLGAQRLAEL------------LLEREPLCLRPEAPSRAPAEG-- 251

  Fly   237 TSTPSSSSNSESNHLAVECADLRSKNRKLRQELEEKSENLLELREELDDKKARFDKLRQESQEWF 301
                      .|:|||::.|:.:::.|:||||||||:|.||:.:.|:...:|...:||||:|...
Human   252 ----------PSHHLALQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALS 306

  Fly   302 TEAKRASAYRDEVDILRERAERADRLEVEVQKYREKLGDSDFYKSRVEELREDNRVLLESKEMLE 366
            .:||||..||:|.:.|||||.|..||:.|:::.||:|..::.|||::||.|..:.||..||.:||
Human   307 GQAKRAELYREEAEALRERAGRLPRLQEELRRCRERLQAAEAYKSQLEEERVLSGVLEASKALLE 371

  Fly   367 EQLQRYRKRSEHAISLESEIIKYKQKINDMALERDVDRSKLEELLEENSQLQLVARNLNSTMDLD 431
            |||:..|:|.......:.|.:..:.::.:...|.|..|.::::|.|||.:|:|         :|.
Human   372 EQLEAARERCARLHETQRENLLLRTRLGEAHAELDSLRHQVDQLAEENVELEL---------ELQ 427

  Fly   432 KSF-----SENEDDCNSGDNSLSEQLTNNAQTRALKLELENRRLTAALEQLKESSFHESTSKMLE 491
            :|.     |..|........||.:::......|...||.|||.|...|:.|:...  .....:||
Human   428 RSLEPPPGSPGEAPLAGAAPSLQDEVREAEAGRLRTLERENRELRGLLQVLQGQP--GGQHPLLE 490

  Fly   492 LEKEKKKLSLKIEQMQENI------NRLTQQNVE------------LEGVFK-----------NA 527
            ..:|...|.:..|..|..:      ..|.|:..:            |:.|.:           :.
Human   491 APREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPDSDP 555

  Fly   528 LEENKKLQDAV--------------------DNRQKSYDRQSLE--------------------- 551
            .|....||.|.                    ::.:|:..|.||:
Human   556 QEAESPLQAAAMDPQASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLL 620

  Fly   552 ------READRQKL--------SDAEQHVETLNKEKQRIQTLNESIQRRADDLERLAESKTKELE 602
                  |||.:.:|        .:..:| :....|...:|...:....:..|| ...:::.:|.:
Human   621 GGETEGREAPQGELVPEAWGLRQEGPEH-KPGPSEPSSVQLEEQEGPNQGLDL-ATGQAEAREHD 683

  Fly   603 QYLE---KSRQYELTKQKLYEIEARVSTYE------------RENASLLKEVSKLKEGSEQKSVQ 652
            |.||   :...::..:|| .|....|..:|            .|..:|.:||::|:..:|....:
Human   684 QRLEGTVRDPAWQKPQQK-SEGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDE 747

  Fly   653 LDDSINRLDVQSKELQKLGKALEDSEQVH-----------------QKLVELEKQNQELASQRII 700
            |:....:|:.|:.|..:|.|.|..:.:..                 ::.||...|..|.|||.
Human   748 LEAQARKLEAQNTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQE-- 810

  Fly   701 DQEMISTLRNDLVTGTLVTKKVRNNLEKLGLADEEPGELNVEHVVEKLVRNPETFKTVREIMLNV 765
                    |..||.......:.|...|:.|               .:|....|..:...:::.:.
Human   811 --------REALVEALAAAGRERRQWEREG---------------SRLRAQSEAAEERMQVLESE 852

  Fly   766 TREQLEEEEREGGVKS------DMCVL--------------------CHRQEIF----------- 793
            .|:.|||.|||...|.      :..|:                    ..|||..
Human   853 GRQHLEEAERERREKEALQAELEKAVVRGKELGDRLEHLQRELEQAALERQEFLREKESQHQRYQ 917

  Fly   794 ----TVEKNIELAATPAPAPAQPSSQELRFEHKVRLSPARES--------AELTRIKDSNTQL-Q 845
                .:|..::.|||        |.:|...|.|.|.....|.        |.|...|.:..|| :
Human   918 GLEQRLEAELQAAAT--------SKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLVE 974

  Fly   846 TENARL-----SVDVA---AL---------GSQI----------TSLNTQ--------------- 868
            |:|.||     ||.|.   ||         ||.:          .|:::|
Human   975 TQNVRLIEVERSVSVGPQWALGRCPVQCECGSTVDPGLGGIPCSVSVDSQWARGWGCPMQCECGP 1039

  Fly   869 ---------HVALQLANSQLAAEKDSLLKEID------------------------------SLQ 894
                     |:|  :||....||.|:..:|..                              ..|
Human  1040 VVGTRGCPRHLA--IANPHFWAECDAGGREGSFAGAAAAPGGAAGEPAGPCPGAAAAEPAGAGAQ 1102

  Fly   895 Q---------------------------------------------------------------- 895
            |
Human  1103 QPPAGREVCAGDSGPGAAPEAGGAGGGGAGGTAVPGGDPRAAAGPASGPQGPGTAAAAAGGRARG 1167

  Fly   896 --------EHKHA--------LQDQVTLQCLHDQLSAEYESLNKDKEQLKAAVRDLRQELRDTRE 944
                    :.:||        ......:...|:||.|:..|:...:..|.|.    |:.|.....
Human  1168 TAGAAPRPQGQHAGTGAGPPGAAGPPLVHPRHEQLQAQRASVEAQEVALLAE----RERLMQDGH 1228

  Fly   945 QQSALEQRIEELTIQNSNMKTCSEDLSILRTEHSKLTDDFRNLFATSDRFKNEYKNIQEQYKMVR 1009
            :|..||                 |:|..|::||.:.......|.......:.|...::.:...:.
Human  1229 RQRGLE-----------------EELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARLE 1276

  Fly  1010 MEHSSLKLQNTELSGELNAKSDQVRCLQMEYSKVQQRCEMLIQNNAELDSERKALMDNVSQLLSQ 1074
            :|.:.|::|:.:|. |.|.:.|...|      ::..:||:|.|..:..:.|.:.|:..|..|..:
Human  1277 LERAQLEMQSQQLR-ESNQQLDLSAC------RLTTQCELLTQLRSAQEEENRQLLAEVQALSRE 1334

  Fly  1075 YQELLAISLEDKKHFHEEEKNYTERVHSLKRQKEKLEEKIMEHYKKSETTVHKKKPFASMLVRRV 1139
            .:|||..|||.:.|.|.|::.|.:::::|:|:|:||.||||:.|:..|          .:.:.|.
Human  1335 NRELLERSLESRDHLHREQREYLDQLNALRREKQKLVEKIMDQYRVLE----------PVPLPRT 1389

  Fly  1140 KKASSDLMNKVP-------------SRNRRSWVDDARTNSQFVIGSESG------------GNES 1179
            ||.|. |.:|.|             :...|.|...:..||  ..||..|            ||:|
Human  1390 KKGSW-LADKGPLPRHPCAGPRAPSACGMRPWQAGSGGNS--AQGSRWGEALSHSALGTPLGNDS 1451

  Fly  1180 DNSNEEPLSIASDTH---LLQRNVPLRQSLQRDLLDNSIQRGGAVRSSLQAQKRTDLN-NSRRN- 1239
            |::.:.|....|.|.   :.....|||                ..|::.|......|. .:|||
Human  1452 DSAIQAPWGRPSPTAKDLVWDGRTPLR----------------PCRNTKQMPTERALRYRNRRNV 1500

  Fly  1240 -SVHGSLEAPDVTGSSLTLGTAGSRRTVYLIDEHQKLPDGSTPGATQSQSVGGSGSVNAAPPTPA 1303
             |.|.|        :|.|:||||.               |..|....|.|.|           |.
Human  1501 PSPHPS--------ASDTVGTAGL---------------GVQPSRHWSVSGG-----------PR 1531

  Fly  1304 EPQTPQKSTENNAPVGPA----TFLMYNRINTTIGGAS--------NSGDQSPLLQASGSVSGTT 1356
            :|    ||:.:..|.|.:    .:.:  |.:|...||.        :.||..|...|.|..||::
Human  1532 QP----KSSGSQGPQGESLDKEAWAL--RSSTVSAGARRWSWDECVDRGDGWPPRAAPGWSSGSS 1590

  Fly  1357 MQDDKSARKRTEDKSNSIWYE 1377
            .......|...:..:...|.|
Human  1591 RWLPLRQRSLGDPPAEGGWQE 1611

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Girdin	NP_647780.1	SMC_prok_B	315..1112	CDD:274008	220/1128 (20%)
		SynN	884..1006	CDD:294095	25/231 (11%)
CCDC88B	XP_011543259.1	SMC_prok_B	<259..964	CDD:274008	169/751 (23%)
		TMEM119	<520..669	CDD:292352	18/149 (12%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141682
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46726
OrthoDB	1	1.010	-	-		D38555at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18947
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.820