Protein Alignment Girdin and CCDC88B

DIOPT Version :10

• Sequence 1: NP_647780.1
• Gene: Girdin / 38385
• FlyBaseID: FBgn0283724
• Length: 1381
• Species: Drosophila melanogaster
• Sequence 2: NP_115627.6
• Gene: CCDC88B / 283234
• HGNCID: 26757
• Length: 1476
• Species: Homo sapiens
• Alignment Length: 1603
• Identity: 376/1603 - (23%)
• Similarity: 635/1603 - (39%)
• Gaps: 435/1603 - (27%)

  Fly    14 EFVNSSIISW---LESCLPRAELLAG----------------YTSLLDGHIIHSVWLQIDPEPQN 59
            :|::.|:.:|   |...:..||...|                :..|.||.::..|...|.|..:.
Human    11 DFLSGSLATWALGLAGLVGEAEDSEGEEEEEEEEPPLWLEKRFLRLSDGALLLRVLGIIAPSSRG 75

  Fly    60 NPSELNDLNGKSLSIARAKNFECVVRNLKSFFEEELGQTILVL---PDAFTLGHHPESKNGLEQM 121
            .|..|..|:|.  :..|..|...:...|:.|::|||  .:|:|   ||..|||..|.|:..:||:
Human    76 GPRMLRGLDGP--AAWRVWNLNHLWGRLRDFYQEEL--QLLILSPPPDLQTLGFDPLSEEAVEQL 136

  Fly   122 KTLLTLLLGAAVQCPNKELFIARIKELDLETQHAIVGLIKQVTDSHSLV-----------LTEDS 175
            :.:|.|||||:|||.::||||..|:.|.||.|..:...|::||...:.|           |....
Human   137 EGVLRLLLGASVQCEHRELFIRHIQGLSLEVQSELAAAIQEVTQPGAGVVLALSGPDPGELAPAE 201

  Fly   176 LERLTPQSMYTHILRLTKERDVMYLKWIDLACVETEMTASDNLVE----CGQGVSVTRSPSNGTA 236
            ||.|:...|.| :.:|.:|||:...:..:|            |:|    |.:..:.:|:|:.|
Human   202 LEMLSRSLMGT-LSKLARERDLGAQRLAEL------------LLEREPLCLRPEAPSRAPAEG-- 251

  Fly   237 TSTPSSSSNSESNHLAVECADLRSKNRKLRQELEEKSENLLELREELDDKKARFDKLRQESQEWF 301
                      .|:|||::.|:.:::.|:||||||||:|.||:.:.|:...:|...:||||:|...
Human   252 ----------PSHHLALQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALS 306

  Fly   302 TEAKRASAYRDEVDILRERAERADRLEVEVQKYREKLGDSDFYKSRVEELREDNRVLLESKEMLE 366
            .:||||..||:|.:.|||||.|..||:.|:::.||:|..::.|||::||.|..:.||..||.:||
Human   307 GQAKRAELYREEAEALRERAGRLPRLQEELRRCRERLQAAEAYKSQLEEERVLSGVLEASKALLE 371

  Fly   367 EQLQRYRKRSEHAISLESEIIKYKQKINDMALERDVDRSKLEELLEENSQLQLVARNLNSTMDLD 431
            |||:..|:|.......:.|.:..:.::.:...|.|..|.::::|.|||.:|:|         :|.
Human   372 EQLEAARERCARLHETQRENLLLRTRLGEAHAELDSLRHQVDQLAEENVELEL---------ELQ 427

  Fly   432 KSF-----SENEDDCNSGDNSLSEQLTNNAQTRALKLELENRRLTAALEQLKESSFHESTSKMLE 491
            :|.     |..|........||.:::......|...||.|||.|...|:.|:...  .....:||
Human   428 RSLEPPPGSPGEAPLAGAAPSLQDEVREAEAGRLRTLERENRELRGLLQVLQGQP--GGQHPLLE 490

  Fly   492 LEKEKKKLSLKIEQMQENI------NRLTQQNVE------------LEGVFK-----------NA 527
            ..:|...|.:..|..|..:      ..|.|:..:            |:.|.:           :.
Human   491 APREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPDSDP 555

  Fly   528 LEENKKLQDAV--------------------DNRQKSYDRQSLE--------------------- 551
            .|....||.|.                    ::.:|:..|.||:
Human   556 QEAESPLQAAAMDPQASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLL 620

  Fly   552 ------READRQKL--------SDAEQHVETLNKEKQRIQTLNESIQRRADDLERLAESKTKELE 602
                  |||.:.:|        .:..:| :....|...:|...:....:..|| ...:::.:|.:
Human   621 GGETEGREAPQGELVPEAWGLRQEGPEH-KPGPSEPSSVQLEEQEGPNQGLDL-ATGQAEAREHD 683

  Fly   603 QYLE---KSRQYELTKQKLYEIEARVSTYE------------RENASLLKEVSKLKEGSEQKSVQ 652
            |.||   :...::..:|| .|....|..:|            .|..:|.:||::|:..:|....:
Human   684 QRLEGTVRDPAWQKPQQK-SEGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDE 747

  Fly   653 LDDSINRLDVQSKELQKLGKALEDSEQVH-----------------QKLVELEKQNQELASQRII 700
            |:....:|:.|:.|..:|.|.|..:.:..                 ::.||...|..|.|||.
Human   748 LEAQARKLEAQNTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQE-- 810

  Fly   701 DQEMISTLRNDLVTGTLVTKKVRNNLEKLGLADEEPGELNVEHVVEKLVRNPETFKTVREIMLNV 765
                    |..||.......:.|...|:.|               .:|....|..:...:::.:.
Human   811 --------REALVEALAAAGRERRQWEREG---------------SRLRAQSEAAEERMQVLESE 852

  Fly   766 TREQLEEEEREGGVKS------DMCVLCHRQ---EIFTVEKNIELAATPAPA-PAQPSSQ----- 815
            .|:.|||.|||...|.      :..|:..::   .:..:::.:|.||..... ..:..||
Human   853 GRQHLEEAERERREKEALQAELEKAVVRGKELGDRLEHLQRELEQAALERQEFLREKESQHQRYQ 917

  Fly   816 --ELRFEHKVRLSPARESAELTRIKDSNTQLQTENARLSVDVAALGSQ-------ITSLNTQHVA 871
              |.|.|.:::.:...:...|..:|....||:.|..:|....|.||.:       :.:.|.:.:.
Human   918 GLEQRLEAELQAAATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIE 982

  Fly   872 LQLANSQLAAEKDSLLKEIDSLQ--------------------QEHKHALQDQVTLQCLHDQLSA 916
            ::.:|:.|.|||.:|..::..|:                    |||...||.:.::      |..
Human   983 VERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSV------LEI 1041

  Fly   917 EYESLNKDKEQLKAAVRDLRQELRDTREQQSAL--------------EQRIEELTIQNSNMKTCS 967
            :.:.|::..|.|:..||..||...:||.||.||              |..:|.|.:::.::|...
Human  1042 QGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANM 1106

  Fly   968 EDLSI----LRTEHSKLTDDFRN-------LFATSDRFKNE---YKNIQEQYKMVRMEHSSLKLQ 1018
            ..|.:    |:..|.:|.....:       |.|..:|...:   .:.::|:.:.::.||...::.
Human  1107 RALELAHRELQGRHEQLQAQRASVEAQEVALLAERERLMQDGHRQRGLEEELRRLQSEHDRAQML 1171

  Fly  1019 NTELS---GELNAKSDQVR----CLQMEYSKVQQRCEMLIQNNAELD------------------ 1058
            ..|||   |||..:..::|    .|::|.::::.:.:.|.::|.:||
Human  1172 LAELSRERGELQGERGELRGRLARLELERAQLEMQSQQLRESNQQLDLSACRLTTQCELLTQLRS 1236

  Fly  1059 ---SERKALMDNVSQLLSQYQELLAISLEDKKHFHEEEKNYTERVHSLKRQKEKLEEKIMEHYKK 1120
               .|.:.|:..|..|..:.:|||..|||.:.|.|.|::.|.:::::|:|:|:||.||||:.|:.
Human  1237 AQEEENRQLLAEVQALSRENRELLERSLESRDHLHREQREYLDQLNALRREKQKLVEKIMDQYRV 1301

  Fly  1121 SETTVHKKKPFASMLVRRVKKASSDLMNKVPSRNRRSWVDDARTNSQFVIGSESGGNESDNSNEE 1185
            .|.....:....|.|..:||:    ||     |.||.             |...||
Human  1302 LEPVPLPRTKKGSWLADKVKR----LM-----RPRRE-------------GGPPGG--------- 1335

  Fly  1186 PLSIASDTHLLQRNVPLRQSLQRDLLDNSIQRGGAVRSSLQAQKRTDLNNSRRNSVHGSLEAPDV 1250
             |.:.:|                         |.....||.....|:|...|        || |.
Human  1336 -LRLGAD-------------------------GAGSTESLGGPPETELPEGR--------EA-DG 1365

  Fly  1251 TGSSLTLGTAGSRRTVYLIDE------HQKLPD-------------GSTP------------GAT 1284
            |||........::.::.|.||      .:||..             |.||            ||.
Human  1366 TGSPSPAPMRRAQSSLCLRDETLAGGQRRKLSSRFPVGRSSESFSPGDTPRQRFRQRHPGPLGAP 1430

  Fly  1285 QSQSVG-GSGSVNAAP-----PTPAEPQTPQKSTENNAPVGPA 1321
            .|.|.| |.|..|:|.     .|.|..:.|:.......|:.|:
Human  1431 VSHSKGPGVGWENSAETLQEHETDANREGPEVQEPEKRPLTPS 1473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Girdin	NP_647780.1	HkD_HkRP	15..165	CDD:411794	55/171 (32%)
		SMC_prok_B	315..1110	CDD:274008	215/1015 (21%)
CCDC88B	NP_115627.6	HkD_Gipie	10..180	CDD:411801	55/172 (32%)
		SMC_prok_B	<259..1011	CDD:274008	179/790 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	427..451		5/23 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	509..706		28/199 (14%)
		Smc	<738..>1297	CDD:440809	125/589 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	825..866		12/55 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1323..1476		44/213 (21%)