DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Girdin and grdn-1

DIOPT Version :9

Sequence 1:	NP_647780.1	Gene:	Girdin / 38385	FlyBaseID:	FBgn0283724	Length:	1381	Species:	Drosophila melanogaster
Sequence 2:	NP_001256816.1	Gene:	grdn-1 / 190137	WormBaseID:	WBGene00013082	Length:	1319	Species:	Caenorhabditis elegans

Alignment Length:	1525	Identity:	345/1525 - (22%)
Similarity:	619/1525 - (40%)	Gaps:	386/1525 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 WLESCL-----PRAELLAGYTSLLDGHIIHSVWLQIDPEPQNNPSELNDLNGKSLSIARAKNFEC 82
            ||..|.     |..:..| ....|||.::.::...|:|    :.|| |:.||:||       :|.
Worm    15 WLCDCAAIIPNPATQNFA-KNDFLDGLLMLNLMKFINP----HFSE-NEKNGQSL-------YEE 66

  Fly    83 VVRNLKSFFEEELGQTILV-LPDAFTLGHHPESKNGL-----EQMKTLLTLLLGAAVQCPNKELF 141
            ::..:..|:|:.|.|.|:. :|:...|    ||...:     |::|.||.||||.|:|..:|::|
Worm    67 LLNQISQFYEKNLDQVIVCKMPEISIL----ESSGEIDEITFEELKKLLLLLLGCAIQSDHKKVF 127

  Fly   142 IARIKELDLETQHAIVGLIKQVTDSHSLVLTEDSLERLTPQSMYTHILRLTKERDVM-----YLK 201
            :.||...|...|..:...|:::|:|..:|...:..||           |..||.|.:     .::
Worm   128 VDRITGFDQTIQAELAACIQKLTESDEIVQNLEDFER-----------RKMKETDEVGGGGGSIE 181

  Fly   202 WIDLACVETEMTASDN----LVECGQGVSVTRSPSNGTATSTPSSSSNSESNHLAVECADLRSKN 262
            .:|...:|:..|:|.|    :.:..|...::|           |:|..||..|..::.|:|:.:.
Worm   182 DVDSDDMESSTTSSSNGEIAIKQQDQSFLMSR-----------STSPTSELRHQTLQIANLQHEM 235

  Fly   263 RKLRQELEEKSENLLELREELDDKKARFDKLRQESQEWFTEAKRASAYRDEVDILRERAERADRL 327
            |::|.:.|.:.|...:|..:.::|..:...|..|..:.....|:..:..|::.....:.|:...|
Worm   236 RQMRTQAENRDEECQKLELDNEEKAQKIKILENERLKLVDFKKKWKSVNDDLQEANCKIEKLQNL 300

  Fly   328 EVEVQKYREKLGDSDFYKSRVEELREDNRVLLESKEMLEEQLQRYRKRSEHAISLESEIIKYKQK 392
            ....:||||.....:.|||:.:.:.:.|..:.|:...||:.|:..:...:....:|..:.:.:..
Worm   301 VGIEKKYREARDGKELYKSKYDIVVKKNLEMEETITTLEKNLKTLQMEMKEKFGVEDNLQRMRNT 365

  Fly   393 INDMALERDVDRSKLEELLEENSQLQLVARNLNSTMDLDKSFSENEDDCNSGD-----------N 446
            |:|:..|......::|:.|:|..:             :|:...|.::..:..:           :
Worm   366 IDDLEAEISKKNLEIEDFLDEKHR-------------MDREIKELKEIVHQMEVPSTTTTPRIMD 417

  Fly   447 SLSEQLTNNAQTRALKLELENRRLTA-------------------------ALEQLKESSFHEST 486
            ||::||.|..|.....::.|.|:|.|                         :.||.:.:..|...
Worm   418 SLADQLENAKQDEFEMMKAEIRKLRAQTEGATPETTIIQCNQDLDTLRSQLSTEQHQTAQLHLEI 482

  Fly   487 SKMLELEKEK-----KKLSLKIEQMQENINRLTQQNVELEGVFKNALEENKKLQDAVDNRQKSYD 546
            .|| ::|||:     :::.:::|:|...:..|   |:|.:...|..||..:|..:.    |....
Worm   483 QKM-QVEKEQIDGNMERIGIELEEMSAQVENL---NLERDEAVKQLLEARRKFGEF----QMGQS 539

  Fly   547 RQSLEREADRQKLSDAEQHVETLNKEKQRIQTLNESIQRRADDLERLAESKTK------ELEQYL 605
            | .||.:..::        ||..||..::.:.|.|.:| .:|.|  ||:|:.:      ||::.|
Worm   540 R-DLEEKWSKE--------VEKSNKISKKCEILEEKLQ-ESDFL--LAKSRDEAKKLQFELDEAL 592

  Fly   606 EK--------SRQYELTKQKLYEIEARVSTYERENASLL--KEVSKLKEGSEQKSVQLDDSIN-- 658
            |:        |.:....|.||.|::.:|   |.:...||  |...|..|..:|....|.:..|
Worm   593 EETSHVTRSLSSEKNTLKAKLLELQDQV---EAQTLELLNQKNCGKRLEDRDQMISNLHNLKNEL 654

  Fly   659 ---------RLDVQSKELQKLGK--ALEDSE------QVHQKLVEL-------EKQNQELASQRI 699
                     :|:::||:||:|.:  .||.|.      ::|.....|       ||.|.
Worm   655 ENDLKTCQTQLELESKKLQRLREDLVLEKSRRADLIGRIHSLCTTLSLNGANFEKINN------- 712

  Fly   700 IDQEMISTLRNDLVTGTLVTKKVRNNLEKLGLADEEPGEL-NVEHVVEKLVRNP-----ETFKTV 758
             |.|:|..:.:.::...:..|:.|::|...|  :::..|| :::..:|||.|:.     |:...|
Worm   713 -DDELIDNIDDIMMNALVAVKRERDDLRIQG--NQQIQELHDLKRDIEKLRRSESESLNESDDRV 774

  Fly   759 REIMLNVTREQLEEEER-------------EGGVKSDMCVLCHRQEIFTVEKNIELAATPAPAPA 810
            ||:    |||.:..:|:             |...|:|        ||..|:.:||.....:.|..
Worm   775 REL----TRENMHTKEQVFMLQEKLRELNLELSTKND--------EIDMVKASIEELNRNSTASC 827

  Fly   811 QPSSQELRFEHKVRLSPARESAELTRIKDSNTQLQTENARLSVDVAALGSQITSLNTQHVALQLA 875
            ..:::..|.:..:|.|..:|..    :|..||:|:.|                          |.
Worm   828 TSNAEIARLQVSIRNSQIQEDL----VKQENTKLRDE--------------------------LQ 862

  Fly   876 NSQLAAEKDSLLKEIDSLQQEHKHALQDQVTLQCLHDQLSAEYESLNKDKEQLKAAVRDL-RQEL 939
            ..|..::|.|  :.:|.|:..||..|.|...||.||:.|:.:|:...|:..:|:..|::: ||:.
Worm   863 EMQKMSKKRS--QNLDELENMHKTLLVDHSRLQQLHNLLTRDYDEAKKESMELRQKVQNIPRQQA 925

  Fly   940 ----RDTREQQSALEQRIEELTIQNSNMKTCSEDLSILRTEHSKLTDDFRNLFATSDRFKNEYKN 1000
                .:.||.::.|.:.|..........|.|       |.....|..|...|..|.|....|
Worm   926 VFMNANIRELEAKLSEEISRREQLEKEHKMC-------RIHCENLRRDITELVQTRDELSLE--- 980

  Fly  1001 IQEQYKMVRMEHSSLKLQNT---ELSGELNAKSDQVRCLQMEYSKVQQRCEMLIQNNAELDSERK 1062
                   :|..|.:...:|.   ||..:||.|..:|       :|:..:.|.|.|.|...:.|.:
Worm   981 -------LRRAHDTCHNKNNQIDELKKQLNQKISEV-------NKLSSKIEALSQLNRTYNEENR 1031

  Fly  1063 ALMDNVSQLLSQYQELLAISLEDKKHFHEEEKNYTERVHSLKRQKEKLEEKIMEHYKKSE---TT 1124
            .|...:..||:|.:|||..:|.||..:|.|.|::.:::.:|:|.|||||:|||:.|:..|   :|
Worm  1032 NLSRQLEILLTQNKELLQRALHDKDQYHLEMKDFQDQLSALRRHKEKLEDKIMDQYRTMENKKST 1096

  Fly  1125 VHKKKPFASMLVRRVKKASSDLMNKVPSRNRRSWVDDARTNSQFVIGSES------GGNESDNSN 1183
            ..:|:|.       ||:|:..|:|    |.|.:....:.|....|..::.      .|...|..:
Worm  1097 PERKQPL-------VKRAAKALIN----RRRATSNGGSTTEDSSVYSADERSSPPLAGTNEDVDH 1150

  Fly  1184 EEPLSIASDTHLLQRNVPLRQSLQRDLLDNSIQRGGAVRSSLQAQKRTDLNNSRRNSVHGSLEAP 1248
            ..|...:||.|              |::            |.....:..|..||.:.:.||:.:|
Worm  1151 LPPTCSSSDDH--------------DVI------------SPDFSAKNPLLRSRNDFMGGSVRSP 1189

  Fly  1249 DVTGSSLTLGTAGSRRTVYLIDEH--------QKLPDGSTPGATQSQSVGGSGSVNAAPPTPAEP 1305
            ...|:.              .|.|        .::|..::|         .:.|:.:.||.|...
Worm  1190 RRYGND--------------HDGHIYTSPFLPPRVPIRNSP---------MTSSLRSRPPPPPYN 1231

  Fly  1306 QTPQKSTENNA----PVGPAT----FLMYNRINTTIGGASNSGDQSPLLQASGSVSGTTM----- 1357
            ::|....|.|:    |:..:|    .|...|:   :|    .|::..|::........|:
Worm  1232 RSPAHKIEQNSSFFEPIAHSTPNSSILEERRV---VG----EGEKRELVRDKEERIDKTLSYYEN 1289

  Fly  1358 ----QDDKSARKRTEDKSN--SIWYEYGCV 1381
                |:.....:.::.|.|  :||:|||||
Worm  1290 VNLPQNPPDLPENSDLKPNESTIWHEYGCV 1319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Girdin	NP_647780.1	SMC_prok_B	315..1112	CDD:274008	206/906 (23%)
Girdin	NP_647780.1	SynN	884..1006	CDD:294095	31/126 (25%)
grdn-1	NP_001256816.1	SMC_N	281..1083	CDD:330553	208/915 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166473
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	233	1.000	Inparanoid score	I2169
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46726
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002681
OrthoInspector	1	1.000	-	-		oto18975
orthoMCL	1	0.900	-	-		OOG6_104888
Panther	1	1.100	-	-	LDO	PTHR18947
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3090
SonicParanoid	1	1.000	-	-		X2052
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.930