DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Girdin and ccdc88ab

DIOPT Version :9

Sequence 1:	NP_647780.1	Gene:	Girdin / 38385	FlyBaseID:	FBgn0283724	Length:	1381	Species:	Drosophila melanogaster
Sequence 2:	XP_017209908.1	Gene:	ccdc88ab / 100498671	ZFINID:	ZDB-GENE-100701-3	Length:	1843	Species:	Danio rerio

Alignment Length:	1885	Identity:	498/1885 - (26%)
Similarity:	788/1885 - (41%)	Gaps:	564/1885 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 IDEFVNSSIISW---LESCLPRAELLAGYTSLLDGHIIHSVWLQIDPEPQNNPSELNDLNGKSLS 73
            ::||:.|.::.|   :|..|.....||.:.:|.||..::.:.::|:|......:.....|..:|
Zfish     8 LEEFIRSPLVCWVKTVERLLTDGSPLAEFMALADGVFLNDIMIRINPNTSVQRAHKKVNNDPTL- 71

  Fly    74 IARAKNFECVVRNLKSFFEEELGQTILV-LPDAFTLGHHPESKNGLEQMKTLLTLLLGAAVQCPN 137
              |.:|...:..::|::::|.|.|.::: |||...||..|.|:..||:|:.||.||||.||||..
Zfish    72 --RIQNLSILTLHIKTYYQEVLQQLVVMSLPDVLVLGRTPLSEQALEEMRKLLLLLLGCAVQCDR 134

  Fly   138 KELFIARIKELDLETQHAIVGLIKQVTDSHSLVL-------TE------DSLERLTPQSMYTHIL 189
            ||.:|.||:.|||:||.||...|::||.....|.       ||      |||.|    :|..::.
Zfish   135 KEEYIDRIQTLDLDTQAAIAAHIQEVTHDQENVFDLQCVEETECVSQDKDSLIR----NMSVNLK 195

  Fly   190 RLTKERDVMYLKWIDLACVETEMTASDNLVECGQGVSVTRSPSNGTATSTPSSSSNSESNHLAVE 254
            ||..|||           ...||..|.:|.....|::|..||::     :||........||:||
Zfish   196 RLVDERD-----------QHAEMIVSLSLERDCPGLTVAPSPAD-----SPSMRRTESVQHLSVE 244

  Fly   255 CADLRSKNRKLRQELEEKSENLLELREELDDKKARFDKLRQESQEWFTEAKRASAYRDEVDILRE 319
            .||.::|.|:||||||||:|.||:.|:|||:.:....:|:||:|:...:|:....||||:|.|||
Zfish   245 LADAKAKIRRLRQELEEKTEQLLDCRQELDNMEEEAKRLQQENQQLQCDARSLRVYRDELDALRE 309

  Fly   320 RAERADRLEVEVQKYREKLGDSDFYKSRVEELREDNRVLLESKEMLEEQLQRYRKRSEHAISLES 384
            :|.|.|:||.||.:|:|||.|.:||::|||||:|||:||||:|.:||:|||..|.|::....||.
Zfish   310 KAVRVDKLESEVTRYKEKLHDIEFYRTRVEELKEDNQVLLETKSVLEDQLQSARARADKHHELEK 374

  Fly   385 EIIKYKQKINDMALERDVDRSKLEELLEENSQLQL-----VARNLNSTMDLDK-SFSENEDDCNS 443
            |.::.|.||:||.:||:::|.:||||||||.:|:|     :..:|:...:|:: |.|..|.....
Zfish   375 ENLQLKNKIHDMEMERELERRRLEELLEENLELELKQKQSMEESLHLGWELEQLSRSTPESSHVV 439

  Fly   444 GDNSLSEQLTNNAQTRALKLELENRRLTAALEQLKES-----------------------SFHES 485
            ...||..::.....::.||||.||:.|..::|:|||:                       |...:
Zfish   440 PQKSLGHEVNELTSSQLLKLEKENQELLRSVEELKETEGDTHTLNQQLVQLQVELSADRESLRSA 504

  Fly   486 TSKMLELEKEKKKLSLKIEQMQENINR----LTQQNVEL---------------EGVFKNALEEN 531
            .|...:|.|||::|...:|.::||.:|    |.|:|..|               |...|:..:||
Zfish   505 ESLSTDLLKEKEQLKKTLETLKENADRQVKGLEQENTHLKQTISTLRQRSQVSAEARVKDIEKEN 569

  Fly   532 KKLQDAVDN-----RQKSYDRQSLEREADRQKLSDAEQHVETLNKEKQRIQTLNESIQRRAD--- 588
            :.|.:::..     .|..:..:.|.||.:.||  :..:..|.|..|.:|::...||:|::..
Zfish   570 RLLHESISETSSKANQLEFQSKQLRRELELQK--ERAERAEELELELRRVEREKESLQKKLATLT 632

  Fly   589 ----------------------------------------------------DLERLAES----- 596
                                                                :|.|:.||
Zfish   633 ITCGKVEVLEKENTQLEAEARKLKKALDSLRNASYQLEALEKDNTQLDQENLELRRVVESLRSTG 697

  Fly   597 -KTKELE---QYLEKSR-----QYELTK-------------------------------QKLYEI 621
             |.::||   :.||..|     ..||.|                               :|:.::
Zfish   698 AKAEQLEMENRELEDERTQLRKSLELLKASAKKNERLEVSYQSLDAENQRLQKALENGTRKIQQL 762

  Fly   622 EARVSTYERENASLLKEVSKLKEGS-------------EQKSVQLDDSINRLDVQSKELQK---- 669
            |..:...|.||.||.:.:.:||..|             ||::.||:....:|:.::|.|::
Zfish   763 EGELQEVELENQSLQQSLEQLKISSKGLEPLAQENRVLEQENTQLEKDKKQLEKENKRLRQQADI 827

  Fly   670 ---------------------LGKALEDSEQVHQKLVELEKQNQELASQRIIDQEMISTLRNDLV 713
                                 |||.:...:.:..:|.||||:|:||..|..||::.::.||.:||
Zfish   828 KDSKLDEDNLRISQLEKENRSLGKEISALKDICGRLKELEKENRELVKQSTIDKKTLAALREELV 892

  Fly   714 TGTLVTKKVRNNLEKLGLADEEPGELNVEHVVEKLVRNPETFKTVREIMLNVTREQLE-EEEREG 777
            ...|.|:::.|:||||....|:.| ||.|.::.....:.:.||.:...:.:..|..|| :||:..
Zfish   893 NEKLKTQQINNDLEKLTHELEKIG-LNKEGLLGDEESSDDRFKLLESKLESTLRSSLEIKEEKIA 956

  Fly   778 GVKSDMCVLCH-----RQEIFTVEKNIEL---------AATPAPAPAQPSSQELRFEHKVRLSPA 828
            .:::.:...|:     |||:.||:||.|.         :|..:||..:......|:|
Zfish   957 ALEARLQESCNLNQQLRQELKTVKKNYEALRQRQEEESSAHSSPARGREDLSFSRWE-------- 1013

  Fly   829 RESAELTR-----------------------------------------------------IKDS 840
            :||.|.||                                                     ::::
Zfish  1014 KESQEATRELLRVKDRLIEVERNNATLQAERQALRTQLKQLETQSSNLQAQILALQRQTASLQEN 1078

  Fly   841 NTQLQTENARLSVDVAALGSQITSLNTQHVALQLANSQLAAEKDSLLKEIDSLQQEHKHALQDQV 905
            ||.|||:||:|.|:.:.|.||..||.:|:..||...|....|:|:.::|.:.|:..::..|:|..
Zfish  1079 NTTLQTQNAKLQVENSTLNSQSASLMSQNAQLQTLQSGTEGERDAAVREKEDLRSVYELLLRDHQ 1143

  Fly   906 TLQCLHDQLSAEYESLNKDKEQLKAAVRDLRQELRDTR-------EQQSALEQRIEELTIQNSNM 963
            .|..||::.:||||.|.....:||:..:.|..:.|...       :|::.|||..:||..:...|
Zfish  1144 KLSALHERQAAEYEELIGRHGELKSGHKSLELQHRGLENRYNQLLKQKTELEQLEKELKAEREKM 1208

  Fly   964 -------KTCSEDLSILRTEHSKLTDDFRNLFATSDRFKNEYKNIQEQYKMVRMEHSSLKLQNTE 1021
                   :..:..|..|..||.:|:...:.|...|:..:.|:|:::.|....|:|       .|.
Zfish  1209 ISDSRSHQDTAAQLQKLSQEHLELSSTHQQLHKDSELLQTEHKSLKSQLNAARLE-------QTR 1266

  Fly  1022 LSGELNAKSDQVRCLQMEYSKVQQRCEMLIQNNAELDSERKALMDNVSQLLSQYQELLAISLEDK 1086
            |..:.:...:|.:.|.:..:|:..:||:|.|....|:.|.:.|:|.:..|:.|.:.||..::|.|
Zfish  1267 LEADFSKLKEQYQQLDISSTKLSNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQTMESK 1331

  Fly  1087 KHFHEEEKNYTERVHSLKRQKEKLEEKIMEHYK-------------------------------- 1119
            ..||.|::.|.::::.|:|||||||||||:.||
Zfish  1332 DLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFFDPSPPRRRGNWITLKMKKLIKPKSRERMRS 1396

  Fly  1120 ------KSE------TTVHKKKPFASML----------------VRRVKK----ASSDLMNKVP- 1151
                  :||      |..|.....:|.:                .:||:|    |||:.:.|:|
Zfish  1397 LTQTPSRSESSEGFLTLPHPDSQDSSSIGSGTNSLEDALMHRSSRKRVEKSQTQASSNALKKLPF 1461

  Fly  1152 SRN------------RRS----------------WVD---------------------------- 1160
            .||            |||                |..
Zfish  1462 MRNRTKDKDQMKAVYRRSMSMNDLLQSMAVCEGQWSSSTDHLEAPDGSAIGQQEFGSLDSTSLSL 1526

  Fly  1161 ----DARTNS------------QFVIGSESGGNESDNSNEEP-------LSIASDTHL----LQR 1198
                .||.:|            ||.  ||....|.:.|...|       :|:..|..|    .:|
Zfish  1527 TRGRSARLHSDRGTAASTDDIGQFC--SEEAQGELNGSASRPHSESSGDVSVGVDAQLGAPDARR 1589

  Fly  1199 NVPLR----QSLQRDLLDN---------------------------------SIQRGGAVRSSLQ 1226
            :.|..    .|||:.|.:|                                 |..|.||.|.||:
Zfish  1590 SAPSTGSDVVSLQQFLEENTHTAEDPPSAPPSSRERVKARGILRSSSGRAAASESRSGAGRPSLR 1654

  Fly  1227 ----------AQKRTDLNNSRRNSVHGSLEAPDVTGSSLTLGTA-GS-RRTVY--LIDEHQKLPD 1277
                      |..|......|..|| .:|::..:..:|..:.|| || |||..  |:....:.|.
Zfish  1655 KTESTRARGCAPPRAGSATQRAASV-SALDSSGLPRASSVISTAEGSVRRTSIHDLLSRDSRQPV 1718

  Fly  1278 GSTPGATQSQSVGGSGSVNAAPPTP-------AEP---QTPQKSTENNAPVGP-----ATFL--M 1325
            ...|.|.:|   |.|......|.||       :.|   |.|:.| ...|.:||     :.||  :
Zfish  1719 LVDPPAPRS---GSSSEYGPGPRTPDALHHSASMPCGVQEPRHS-GLRAFLGPSFTVDSIFLDSI 1779

  Fly  1326 YNRINTTIGGASNSGDQSPLLQASGSVSG---TTMQDDKSARKRTED------KSNSIWYEYGCV 1381
            ::....| |||.|....|.......|:||   |......|:.:|..|      ..:.:|||||||
Zfish  1780 FSEPAVT-GGARNQAILSLNTSLVSSISGAPRTASGGADSSEERPADPEACVSAEDGLWYEYGCV 1843

Fly 1382 1381
Zfish 1844 1843

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Girdin	NP_647780.1	SMC_prok_B	315..1112	CDD:274008	281/1069 (26%)
Girdin	NP_647780.1	SynN	884..1006	CDD:294095	34/135 (25%)
ccdc88ab	XP_017209908.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D38555at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010