DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Girdin and hook2

DIOPT Version :9

Sequence 1:	NP_647780.1	Gene:	Girdin / 38385	FlyBaseID:	FBgn0283724	Length:	1381	Species:	Drosophila melanogaster
Sequence 2:	XP_002938530.1	Gene:	hook2 / 100497596	XenbaseID:	XB-GENE-991660	Length:	721	Species:	Xenopus tropicalis

Alignment Length:	807	Identity:	166/807 - (20%)
Similarity:	314/807 - (38%)	Gaps:	240/807 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 SIISWLES------CLPRAELLAGYTSLLDGHIIHSVWLQIDPEPQNNPSELNDLNGKSLSIARA 77
            |:::|:::      |       :.|..|..|..|..|..:||      ||..|:.....:.....
Frog    12 SLLTWMQTFQVSGPC-------SSYEDLTGGVAIAQVLNRID------PSWFNEAWLVRVKQDTT 63

  Fly    78 KNFECVVRNLK-------SFFEEELGQTIL--VLPDAFTLGHHPESKNGLEQMKTLLTLLLGAAV 133
            :|:...|.|||       .::::.||..:.  .:||...:|   |..|..| ::.::.|:||.|:
Frog    64 ENWRIKVSNLKRILQSILEYYQDVLGHPVSDDHIPDVALIG---EFSNAAE-LRKMVQLVLGCAI 124

  Fly   134 QCPNKELFIARIKELDLETQHAIVGLIKQVTDSHSLVLTEDSLERLTPQSMYTHILRLTKERDVM 198
            .|..||..|.:|..|....|.|::..|::       :|::|..:.:|.:|   :|...::.|...
Frog   125 SCDKKEEHIQQIMTLGESVQQAVMESIQE-------LLSKDPTDAVTSES---YINYDSQSRKYY 179

  Fly   199 YLKWIDLACVETEMTASDNLVECGQGVSVTRSPSNGTATSTPSSSSNSESNHLAVECADLR---- 259
            :|                                         |..|.|.|.:...|.||.
Frog   180 FL-----------------------------------------SEDNDEKNEILQRCHDLEQQVS 203

  Fly   260 ----------SKNRKLRQELEEK--------SENLLELREEL--------------DDKKAR--- 289
                      .:||.||::.|:.        ::.||.|:.::              ||.:.|
Frog   204 LLMEEKKNLVGENRNLREQQEQSGMGTPQLFNKKLLLLQSQIEQLQEENYRLESSRDDYRQRCQE 268

  Fly   290 ----FDKLRQESQEWFTEAKRASAYRDEVDILRERAERADRLEVEVQKYREKLGDSDFYKSRVEE 350
                ..:|:|.:|:....|..|.|.|||:|:||..::|..:||..|:.|::||.|....:.:|:.
Frog   269 LDRDIQELQQRNQDLTGLAHEAQALRDEMDVLRHSSDRVGKLESLVESYKKKLEDLGDLRRQVKL 333

  Fly   351 LREDNRVLLESKEMLEEQLQR------------------YRKRSEHAISLES---EIIKYKQKIN 394
            |.|.|.|.::....|||:|.:                  ::|.|..::..|.   |....|:|..
Frog   334 LEERNTVYMQRTCQLEEELHKANASRGQLENLSRQIQELHKKHSTESLRAEKWQFEFQTLKEKFE 398

  Fly   395 DMALERDVDRSKLEELLEENSQLQLVARNLNSTMDLDKSFSENEDDCNSG-----DNSLSEQLTN 454
            .:..||:...::.:.|.|.|.:|:        ...|.::.....|...||     :|..:|.:..
Frog   399 ALQKERERLITERDSLRETNDELR--------CSHLQQTCLGQADVLLSGSSPPLENLAAEIVPA 455

  Fly   455 NAQTRALKLELENRRLTAALEQLKESSFHESTSKMLELEKEKKKLSLKIEQMQENINRLTQQNVE 519
            ..:...::|:.||:.|..     :|:|:.:....:..|.:|    |.:.:...|:.:||.||.:
Frog   456 ELRETVMRLQQENKMLCT-----QEASYQDRLCDLQNLLEE----SNRSKNRMESESRLQQQQI- 510

  Fly   520 LEGVFKNALEENKKLQDAVDNRQKSYDRQSLEREADRQKLSDAEQHVETLN-------KEKQRIQ 577
                        |:|:..|:..||....|....|...|.....|:|:|.|:       |:::.|:
Frog   511 ------------KELKAQVEELQKHLREQGNRAEDSSQLKRKLEEHLEMLHDAHSELQKKREYIE 563

  Fly   578 TLNE----SIQRRADDLERLAESKTKEL-------EQYLEKSR----------------QYELTK 615
            ||..    ::.|:.::|:::...|.:::       ::|::|:|                :.:..|
Frog   564 TLEPKADLNMSRKVNELQQILRQKEEDMRAMEDRYKRYVDKARTVIKSLDPKQQNCIPPEIQALK 628

  Fly   616 QKLYEIEARVSTYERENASLLKEVSKLKEGSEQKSVQLDDSINRLDVQSKELQKLGKALEDSEQV 680
            .:|.|.:.|:...|.:     .|.:|::...|:|.:            ......:|.||
Frog   629 NQLQEKDTRIRHLETD-----YEKTKVQRDHEEKLI------------ISAWYNMGMAL------ 670

  Fly   681 HQKLVELEKQNQELASQRIIDQEMIST 707
            |||..: |:......:|..:.|:.::|
Frog   671 HQKATD-ERSQPPNGAQSFLAQQRLAT 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Girdin	NP_647780.1	SMC_prok_B	315..1112	CDD:274008	93/453 (21%)
Girdin	NP_647780.1	SynN	884..1006	CDD:294095
hook2	XP_002938530.1	HOOK	9..702	CDD:368526	166/807 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910