Protein Alignment Girdin and ccdc88b

DIOPT Version :9

• Sequence 1: NP_647780.1
• Gene: Girdin / 38385
• FlyBaseID: FBgn0283724
• Length: 1381
• Species: Drosophila melanogaster
• Sequence 2: XP_002938745.2
• Gene: ccdc88b / 100496075
• -ID: -
• Length: 2083
• Species: Xenopus tropicalis
• Alignment Length: 1625
• Identity: 368/1625 - (22%)
• Similarity: 665/1625 - (40%)
• Gaps: 433/1625 - (26%)

  Fly    12 IDEFVNSSIISWLES-----------CLPRAELLAGYTSLLDGHIIHSVWLQIDPEPQNNPSELN 65
            :::.::.::|:|:.|           .....:|...|..|.:|.::|.:...|||.|.:...:|:
 Frog     9 LEQLMDGALITWIRSFEQTYNLEYGTLYTTRDLRKEYMQLSEGDMLHFIMSMIDPRPYHGERDLH 73

  Fly    66 DLNGKSLSIARAKNFECVVRNLKSFFEEELGQTILV-LPDAFTLGHHPESKNGLEQMKTLLTLLL 129
            .|.                :.|::::::.|.|.||: |||:..:.....:...:::|:.||:|:|
 Frog    74 SLR----------------KRLRAYYQDGLQQLILMPLPDSTLISQDQITVCSVQEMEKLLSLML 122

  Fly   130 GAAVQCPNKELFIARIKELDLETQHAIVGLIKQVT-DSHSLV---------LTEDSLERLTPQSM 184
            ||||||..:|..|..|:.|.|::|..:...|:::| |:..::         |....|:... ..:
 Frog   123 GAAVQCERREQIITGIRNLTLDSQINLAEKIQEMTQDTQKIIAIPGPELCHLPHSDLQEAV-HML 186

  Fly   185 YTHILRLTKERDVMYLKWIDLAC-VETEMTASDNLVECGQGVSVTRSPSNGTATSTPSSSSNSES 248
            .||:....::||....:...|.| .::..||..:.|..|...|.|..|.|.          .:.|
 Frog   187 STHLRDTLRQRDDAQERLSLLRCEQQSNTTAPGDPVIRGMHPSKTSDPHNW----------KNRS 241

  Fly   249 NHLAVECADLRSKNRKLRQELEEKSENLLELREELDDKKARFDKLRQESQEWFTEAKRASAYRDE 313
            .|:    |||:||.|:.|||||||.|.||:.::.::..:|...||.|:.:|....|..:..||||
 Frog   242 LHV----ADLQSKLRRARQELEEKGEELLDNQQHVEMLEAELRKLHQQVRELSAMAALSRGYRDE 302

  Fly   314 VDILRERAERADRLEVEVQKYREKLGDSDFYKSRVEELREDNRVLLESKEMLEEQLQRYRKRSEH 378
            :|.||||:.||   |.:|....|||...:.::..::|.:|.:|.|||.||:||.||...|:|||.
 Frog   303 LDALRERSRRA---EAQVNALNEKLRTMEIFQRSLQEEKEFSRALLEDKEVLEHQLAAERERSEK 364

  Fly   379 AISLESEIIKYKQKINDMALERDVDRSKLEELLEENSQLQLVARNLNSTM--------------- 428
            ....|.|....:::|..:.:|||.:..:::.||.:|..|....|.|....
 Frog   365 LRLCEKEKHSLEERIQRLEMERDSECQRVQFLLHDNLTLAEEVRVLREETQRGWERVYESHGDTV 429

  Fly   429 ---------DLDKSFSENED------DCNSGDNSLSEQLTNNAQTRALKLELENRRLTAALEQL- 477
                     :.|:|:...::      |.||   .||:.|        |:||.||:.|...|:.|
 Frog   430 PVWEREQDGEADQSWERMQEADPDFLDLNS---ELSQAL--------LRLEKENQNLRERLQGLS 483

  Fly   478 ------KESSFH--------------------------------------ESTSKMLE-LEKEK- 496
                  |....|                                      |...|:.| :|||:
 Frog   484 GETPDPKNKGQHVQTEGEQGGETQLQIRSPDFCVREEPDGGSLGERDRQVEGNRKIHEKVEKEQS 548

  Fly   497 ---------------KKLSLKIE-----QMQENINRLTQQNVELEGVFKNALEENKKLQDAVDN- 540
                           :||...:|     |::|..:....:..:|:|..|.:|  ||..|.:||.
 Frog   549 QSTECEGTDEKNGSLRKLEGSVEGMQPRQLEEIPSEKQSEEAKLKGTDKQSL--NKVCQASVDKG 611

  Fly   541 -------------------------RQKSYD-----RQSLEREADRQKLSDAEQHVETLN---KE 572
                                     .|||.|     :.|.|.||.:::|.::...:::|.   ||
 Frog   612 KPASGNVDRNSKVQIMTVHLEESPLEQKSCDSYWQEKVSCETEALKRQLEESALEIDSLKRQLKE 676

  Fly   573 KQ-----RIQTLNESIQRRADDLERLAESKTKE---LEQYLEKS-RQYELTKQKLYEI--EARVS 626
            ||     :...|:||...: :.|:|..:...:|   |::.|:|| ::..|.|::|..:  |:...
 Frog   677 KQDEAQNQQNQLSESTTEK-NALQRKLQGNAEEILSLQKQLDKSIKECHLLKEELQGMVKESLKM 740

  Fly   627 TYERENASLLKEVSKLKEGSE-------------------QKSVQLDDSI-----NRLDVQSKEL 667
            .:...|..:..:..|::|.||                   ||.:::.|.:     ..|..:|:|:
 Frog   741 QHHDGNEEMQTQKRKVEESSEEILSLQRQLQDIVKKEELLQKQLEISDKMVETQHRNLAERSEEI 805

  Fly   668 QKLGKALEDSEQ-VHQKLVELEKQNQELASQRIIDQEMISTLRNDL--VTGTLVTKKVRNNLEKL 729
            :.|...|:|:|| .|.::.:..|:.:.|..:....||....|...|  :||.:  :.::..||:
 Frog   806 RLLKTKLDDTEQSYHHQMADSAKELKSLKDELKSYQEQEHMLNRQLQEITGEV--QSLKRQLEE- 867

  Fly   730 GLADEEPGELNVEHVVEKLVRNPETFK-----------------TVREIM-----------LNVT 766
               .|:..:....|:.|.::...|..|                 :.:||.           ....
 Frog   868 ---TEKEKQCQQRHLQESVLEAEELQKQLLKALESKELETQLKESAKEIQSLGKQLKESRDAEAL 929

  Fly   767 REQLEEEEREGGVKSDMCVLCHRQEIFTVEKNIELAATPAPAPAQPSSQELRFEHKVRLSPARES 831
            |.||:|.|.:...|.   :..:.::|.:::..:.            .|......|:::|: .||.
 Frog   930 RRQLQEREEQSFKKQ---LQDNAEKIQSLKNQLN------------ESTAENISHEMQLT-EREC 978

  Fly   832 AELTRIKDSNTQLQTENARLSVDVAALGSQITSLNTQHVALQLANSQLAAEK-------DSLLKE 889
            .|    |....||:..|    ||:.:|..|:.....:..:|:....:...||       :|.|||
 Frog   979 LE----KSLKGQLEERN----VDINSLQKQLEKKTEEEKSLKRRLEENEREKQVQQIHLESNLKE 1035

  Fly   890 IDSLQQEHKHALQDQV-----TLQCLHDQLS--AEYESLNKDKEQLKA-AVRDLRQELRDTR--- 943
            :.||:::.|.:..||:     .|..|.:|:.  .:.|.|.|.:.|:.| .|:.|:|:|.|.:
 Frog  1036 VQSLKKQLKKSDNDQMKYSAEQLDSLKNQIEEREKMEQLLKREWQVSAEEVQVLKQQLNDKQENL 1100

  Fly   944 -EQQSALEQ-----------------RIEELTIQ---NS--------NMKTCSEDLSILR----- 974
             |::|.|.|                 .:|:||||   ||        |:|.|.|::..|:
 Frog  1101 EEKESLLRQLLQTNDSMKRQLDEKSKHVEDLTIQFQVNSEKEGTLQKNLKDCEEEIQTLKWKLTD 1165

  Fly   975 -----------TEHSKLTDDF--RNLFATSDRFKNEYKNIQE---QYKMVRMEHSSLK----LQN 1019
                       .|.:|.|:|.  |.|...||..::..::::|   ||:. :.|::.:|    .|.
 Frog  1166 SNNELQSQKIMLERNKETEDSLKRKLVERSDEIQSLKRHLEEAKGQYQK-KQEYTDMKDSPQGQA 1229

  Fly  1020 TELSGELNAKSDQVRCLQMEYSKVQQRCEMLIQNNAELDSERKALMDNVSQLLSQYQEL---LAI 1081
            .:| |||:....|   ||....::|.....|.::.||:.:.::...::..::..|.::|   :..
 Frog  1230 NDL-GELHTLKRQ---LQESTEEMQSLMRQLEESAAEIQTVKRQFQESAEKIQLQKRQLEDSVGE 1290

  Fly  1082 SLEDKKHFHEEEKNYTERVHSLKRQKEK-------LEEKIMEHYKKS---ETTVHKKKPFASMLV 1136
            ||..|:...|.    ..|..|||||.::       |:.::.||.::.   :..:.:|:.....|.
 Frog  1291 SLSLKRQLEER----VGREQSLKRQLDECTAKVQLLKTQLQEHVEEKTLWKNQLEEKEKKMIYLK 1351

  Fly  1137 RRVKKASSDLMNKVPSRNRRS-------WVDDARTNSQFVIGSESGGNESDNSNEEPLSIASDTH 1194
            |::.:.:.|      |..|.|       .:......|:..:.::|...|...||.:       ..
 Frog  1352 RQLDERTKD------SHERESCKSAEIQLLKKELEESKETLKAQSFKGELQESNNK-------IE 1403

  Fly  1195 LLQRNVPLR----QSLQRDLLDNS----IQRGGAVRSSLQAQKRT-DLNNSR------RNSVHGS 1244
            .|||.:..|    ::|:|.|.:::    :|:.....|.|:.|..| .|.:..      :..|.|:
 Frog  1404 TLQRQLQEREDEIETLERKLQESADEVELQKKQLAESLLKEQALTRHLKDKEGYELILKRQVEGA 1468

  Fly  1245 LEAPDVTGSSLTLGTAGSRRTVYLIDEHQKLPDGSTPGATQSQSVGGSGSVNAAPPTP-AEPQTP 1308
            .:..:...:.|     ....|..:....::||:.:..||:..:.:.|:.:...:|.|| :|.:||
 Frog  1469 TQWAEDLQTQL-----NHNSTAKVSSRKRQLPESTGEGASHKKQMEGAKAECLSPLTPQSEGETP 1528

  Fly  1309  1308
             Frog  1529  1528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Girdin	NP_647780.1	SMC_prok_B	315..1112	CDD:274008	240/1075 (22%)
		SynN	884..1006	CDD:294095	48/182 (26%)
ccdc88b	XP_002938745.2	Smc	235..1022	CDD:224117	191/847 (23%)
		Smc	654..1439	CDD:224117	178/837 (21%)
		SMC_prok_B	1178..1966	CDD:274008	80/378 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D38555at33208
OrthoFinder	1	1.000	-	-		FOG0002681
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR18947
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.020