Protein Alignment Girdin and ccdc88b

DIOPT Version :9

• Sequence 1: NP_647780.1
• Gene: Girdin / 38385
• FlyBaseID: FBgn0283724
• Length: 1381
• Species: Drosophila melanogaster
• Sequence 2: NP_001373435.1
• Gene: ccdc88b / 100330741
• ZFINID: ZDB-GENE-080303-31
• Length: 1603
• Species: Danio rerio
• Alignment Length: 1661
• Identity: 381/1661 - (22%)
• Similarity: 672/1661 - (40%)
• Gaps: 451/1661 - (27%)

  Fly    12 IDEFVNSSIISW--------------------LESCLPRAELLAGYTSLLDGHIIHSVWLQIDPE 56
            |:||:.|::::|                    :|..:.....:..|.:|.:|..::.|...|||.
Zfish     9 IEEFMGSALVTWVHLFEGIVGEEEDGSLFPEYMEVNISSQNAVRQYLTLTNGVYLNEVMRIIDPN 73

  Fly    57 PQNNPSELNDLNGKSLSIARAKNFECVVRNLKSFFEEELGQTILV-LPDAFTLGHHPESKNGLEQ 120
            |:......|..:.|   |.|.:||..:.|:|:|:::|.|.|.:|: ||:...||..|.::..:.:
Zfish    74 PKVEQIYHNVGDDK---IRRVQNFSILNRHLRSYYQENLQQLVLMPLPNVAVLGRDPLTEGAVAE 135

  Fly   121 MKTLLTLLLGAAVQCPNKELFIARIKELDLETQHAIVGLIKQVTDSHSLVLTEDSLE-------- 177
            ::.||.||||.||||..||.||.:|:.||::||..|...|::||...|.||   .||
Zfish   136 LRRLLLLLLGCAVQCERKETFIQQIQCLDIDTQAEIALCIQEVTQDRSAVL---PLEFGDLCGLN 197

  Fly   178 ----RLTPQSMYTHILRLTKERDVMYLKWIDLACVETEMTASDNLVECGQGVSVTRSPSNGTATS 238
                ::...||...|..|..:||.. |:.|...|.|.|  :|.|.:          :.|:|....
Zfish   198 GAELQILFCSMAKQIQNLLAQRDTQ-LERIAELCQEQE--SSVNHI----------NTSSGFGDG 249

  Fly   239 TPSSSSNSESNHLAVECADLRSKNRKLRQELEEKSENLLELREELDDKKARFDKLRQESQEWFTE 303
            :|..        ||.:.|:.::|.|:|:||||:|.:.||:.::|:...:....||::||:....|
Zfish   250 SPEG--------LAFQLAESKAKLRRLKQELEDKGDQLLDYKQEMQTMEEEIKKLQKESRALQVE 306

  Fly   304 AKRASAYRDEVDILRERAERADRLEVEVQKYREKLGDSDFYKSRVEELREDNRVLLESKEMLEEQ 368
            .:.:...:||:|.|||||.|.::|:.|::....:|...:.|:::::|.::....|.|:|.:||||
Zfish   307 VRASRGLKDELDCLRERAARVEQLQTELKNCTHRLRSMELYRTQLKEQQQYCASLQENKALLEEQ 371

  Fly   369 LQRYRKRSEHAISLESEIIKYKQKINDMALERDVDRSKLEELLEENSQLQLVARNLNSTMDLDKS 433
            |...|.|......||.|.:..:||:.||..||||:|.:::||||.|..||:..:....:..:::|
Zfish   372 LADARLRCTALRDLEKENLLLRQKLVDMEAERDVERQRVDELLEMNMSLQVDLKRQVHSAGVNQS 436

  Fly   434 FS---------ENEDDCNSGD------NSLSEQLTNNAQTRALKLELENRRLTAALEQLK-ESSF 482
            .:         |:::|....:      ..|||::...:..|.|..|.||..|...||.|: |...
Zfish   437 VTHQHFLQSELESDEDVQEVNMPEIDLKPLSEEVNEASSLRLLGAENENAELRRRLELLQAEQEA 501

  Fly   483 HESTSKMLELEKEKKKLSLKIEQMQENINRLTQQNVEL--------------------------- 520
            .:...|..||::..::||.|::...:.:..|..:|..|
Zfish   502 QQGPEKTQELQRLTEQLSQKLQNTLKELECLKNENSSLKINLEETKRKREEDLKTDRTTSQGKEG 566

  Fly   521 -----------------------EGVFKNALEE--------------NKKLQDAVDNRQK----- 543
                                   |||.|...|:              .||:.|.::::::
Zfish   567 KKPVIPRGECEGNDTRREKHDGKEGVIKARREDGEGGEGGDVILSERRKKVIDEMNSKERGEAEG 631

  Fly   544 ---------------------------SYD--------RQSLEREADRQ---------------- 557
                                       |.|        :|:|| |||||
Zfish   632 EKETENKTDITEETYSDEALKTEHDQFSQDALTLHNQLQQALE-EADRQSALAQDLRSKVAEQSK 695

  Fly   558 KLSDAEQHVETLNKEKQRIQTLNESI--------------QRRADDL------------------ 590
            |:.:||..:..|..|.||::...||:              .::.::|
Zfish   696 KVLEAEHKLAFLETENQRLKKAAESLAEARKQIEVLQGESMQKEEELIRLHSQEELQKMQAAIIA 760

  Fly   591 ----ERLAESKTKE--------LEQYLEKSRQYELTKQKL--------------------YEIEA 623
                ||.|..:.||        |...:.|..|.||..|.|                    .:.|.
Zfish   761 QLEDERAALEREKETLRGSVDSLRAAVRKGDQIELINQNLKADLERLGRTLESSKRHEEELQAEL 825

  Fly   624 RVSTYERENAS-----LLKEVSKLKEGSEQKSVQLDDSINRLDVQSKELQKLGKALEDS----EQ 679
            |.|..|.|:.:     .|.|||:|::..|....:|:.....|..:.:|:.:|.:.||.:    |.
Zfish   826 RESGVEAESLARGREEALLEVSRLEQEKEACQAELESQRRELRQREREMARLRQQLESTSSALEH 890

  Fly   680 VHQK------------------------LVELEKQNQELASQRIIDQEMISTLRNDLVTGTLVTK 720
            .||:                        ..||:|:|.:|||.....:..|.:|..||...:..::
Zfish   891 GHQRACSLEANNRRMCQDLAQLRESCAQFEELQKENTQLASLNAESKAQIDSLTKDLANESAQSR 955

  Fly   721 KVRNNLEKLGLADEEPGELNVEHVVEKLVRNPETFKTVREIMLNVTREQLEEEEREGGVKSDMCV 785
            ::.|.:.:|....||         ::..::.....::..|:.|:....::|..|   |.:|:.
Zfish   956 ELSNQITQLNKTLEE---------LKTRLQMASQQRSTPEVALSPPDSRVESVE---GCESNR-- 1006

  Fly   786 LCH---RQE--IFTVEK-NIELAATPAP-----------------APAQPSSQELRFEHKVRLSP 827
              |   |||  :.|.:| |...::.||.                 ..|:...||...:..:  :.
Zfish  1007 --HSADRQEDTVSTADKVNHNQSSRPADFISAGEDDENTRSKQPHTTAEAGCQEALSQRLI--NT 1067

  Fly   828 ARESAELTR--------------------------------IKDSNTQLQTENARLSVDVAALGS 860
            .||:|.|.|                                ::::..:||..|.:|.|:.|:|.:
Zfish  1068 ERENAVLQREREVLVSQLTQSQSACSQLREQLDTLQRHSISLQENGAKLQALNTKLQVEQASLRA 1132

  Fly   861 QITSLNTQHVALQLANSQLAAEKDSLLKEIDSLQQEHKHALQDQVTLQCLHDQLSAEYESLNKDK 925
            :..|..|:....:|..:.|.||..:.|||.:......:...:|...|..|..:..||.|.|....
Zfish  1133 EHASTLTRCSESELRCAALEAESRAWLKEKEESVMRLEAVRRDHERLTALQQRQEAELEELLVKH 1197

  Fly   926 EQLKAAVRDLRQELRDTREQQSALEQRIEELTIQNSNMKTCSEDLSILRTEHSKLTD-------D 983
            .|||::.|.|..:.:||       |.|.:||..:.:.::...|.:.:.|.:..|:|.       :
Zfish  1198 SQLKSSHRSLEAQCKDT-------EVRYKELLERKAQLEEAEESIRVERQKMEKVTQGQLENEKE 1255

  Fly   984 FRNLFATSDRF---KNEYKNIQE----QYKMVRMEHSSLKLQNTELSGELNAKSDQVRCLQMEYS 1041
            ...|...::|:   :.|:..:|.    |..::|.|.||.:|:.|.|.|:||:..:|.:.|.:.:.
Zfish  1256 LERLKMDNERYLSLQKEWVQVQSELLAQSSVLRAELSSAQLERTRLEGKLNSLKEQNQQLDLNHV 1320

  Fly  1042 KVQQRCEMLIQNNAELDSERKALMDNVSQLLSQYQELLAISLEDKKHFHEEEKNYTERVHSLKRQ 1106
            ::..:.::|.|..|.::.|.:.|::....|..:.:.|:..|||.:...|.:::.|.::::.|:|:
Zfish  1321 RLSSQYQLLTQLKANMEEENRHLVEQNQSLAKENKALMESSLESRDQHHNQQREYLDKLNELRRE 1385

  Fly  1107 KEKLEEKIMEHYKKSETTVHKKKPFASMLVRRVKKAS--SDLMNKVPSRNRRSWVDDARTNSQFV 1169
            |:||.||||:.|:..|..:....|     :::.||::  :|.|.|:......|     :......
Zfish  1386 KQKLVEKIMDQYRVLEPALPAMSP-----LKQAKKSNWIADRMKKLIKPKGGS-----KEGRAHF 1440

  Fly  1170 IGSESGGNESDNSNEEPLSIASDTHLLQRNVPLRQSLQRDLLDNSIQRGGAVRSSLQA---QKRT 1231
            |.:.|..|.:|..:...:|.||.        |:.   .:|.:...:......|.|.|.   |.:.
Zfish  1441 IAAGSVENLADAVDGSAISPASG--------PVH---DQDPISAPVSPSPLRRISYQVEEEQPKA 1494

  Fly  1232 DLNNSRR--NSVHGSLEAPDVTGSSLTLGTAGSRRTVYLIDEHQKLPDGSTPGATQSQ------- 1287
            :|...||  .|.|         |.:|..|..|             :....:||..:||
Zfish  1495 NLRTGRRKLGSRH---------GWALGKGRGG-------------VSQSFSPGDQRSQPRIRLRS 1537

  Fly  1288 SVGGSGSV--NAAPPTPAEPQTPQK----STENNAP 1317
            |..|:.::  :.:.|||::....::    |.||.:|
Zfish  1538 SQTGASALWEHDSSPTPSQDSPSEEGRVDSEENISP 1573

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Girdin	NP_647780.1	SMC_prok_B	315..1112	CDD:274008	236/1098 (21%)
		SynN	884..1006	CDD:294095	30/135 (22%)
ccdc88b	NP_001373435.1	HkD_Gipie	10..180	CDD:411801	53/172 (31%)
		PTZ00121	<255..960	CDD:173412	157/705 (22%)
		Smc	612..1404	CDD:224117	171/817 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574684
Domainoid	1	1.000	169	1.000	Domainoid score	I3771
eggNOG	1	0.900	-	-		E1_KOG4643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46726
OrthoDB	1	1.010	-	-		D38555at33208
OrthoFinder	1	1.000	-	-		FOG0002681
OrthoInspector	1	1.000	-	-		otm24826
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18947
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2052
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.820