DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14964 and Obsl1

DIOPT Version :9

Sequence 1:	NP_647779.2	Gene:	CG14964 / 38384	FlyBaseID:	FBgn0035410	Length:	1443	Species:	Drosophila melanogaster
Sequence 2:	XP_006496646.2	Gene:	Obsl1 / 98733	MGIID:	2138628	Length:	1896	Species:	Mus musculus

Alignment Length:	1710	Identity:	318/1710 - (18%)
Similarity:	507/1710 - (29%)	Gaps:	635/1710 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 SAERPSPP-----GRPI---------LTPVALPEQQPDVVNLRWDRPLHDGGSPITGYTVEHRRM 75
            |.::.|||     .||:         |..|.|.|..|.||   |::    ||..:    |...|:
Mouse     5 SGDQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPTVV---WEK----GGQQL----VASERL 58

  Fly    76 GSPHWVRATPTPVDRCD--VCISGLEPGWRYQFRCFAENIVGRS------------------DAS 120
            ..|.         |..:  :.:||..|.....:.|.|.|..|.:                  ::|
Mouse    59 SFPE---------DGAEHGLLLSGALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPAPEPEPESS 114

  Fly   121 ELSDPLTVTLQRNAITVPRFIDELVDTNAVEDERIEFRVRILGEPPPEINWFKDGY---EIFSSR 182
            |...|...|.:    ..|:|:........:..|.:....::.|.|.|::.|.|||.   |::.|.
Mouse   115 ECPLPTPGTGE----GAPKFLTGPQSQWVLRGEEVVLTCQVGGLPEPKLYWEKDGMALDEVWDSS 175

  Fly   183 RTKI-----VNDNEASV-LVIHQVALTDEGEIKCTATNRAGHVITKARLMVQAP----------- 230
            ..|:     .:|..||: |.|....|.|.|...|.|.|..||....|.|.|..|
Mouse   176 HFKLEPGRGASDEGASLTLRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPRESPPQDPDEN 240

  Fly   231 PKIRL------PRTYEDGLIVEADEVLRLKVGVAGQPPPAITWLHEGEVIAPG-GRFEVSNTEKN 288
            ||..|      |:|:    .|...:..:.:..|.|:|.|.|.|..||..:.|. .|....:.:..
Mouse   241 PKPVLEPLKGAPKTF----WVNEGKHAKFRCYVMGKPEPEIEWHLEGRPLLPDRRRLMYRDRDGG 301

  Fly   289 SLLKIDNVLREDRGEYMVKAWNRLGEDSTSFLVTVTARPNPPGTPKLNMSFGKSATLSWTAPLDD 353
            .:||:.....:|||.|:..|.|..|:..::..:.|                 |...|.:|.||.|
Mouse   302 FVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHV-----------------KEPRLRFTRPLQD 349

  Fly   354 G----------GCKIGNYIVEYFRVGWNVWLKAATTRALSTTLHDLIEGSEYK----FRVKAEN- 403
            .          .||:.|..:.      ..|.: ...|.|....::.||....:    .::||::
Mouse   350 VEGREHGIVVLECKVPNSRIP------TAWFR-EDQRLLPCRKYEQIEEGAVRRLVIHKLKADDD 407

  Fly   404 ---------------------------PYGLSEPSGESELLFIPDPKRGITKPKSATRIAGDEKD 441
                                       |..|....||:.:|.:...:.|:....|.     |.:|
Mouse   408 GVYLCEMRGRVRTVANVTVKGPILKRLPRKLDVLEGENAVLLVETQEAGVQGCWSR-----DGED 467

  Fly   442 KPKTGAGGMQVPPRRKTLSPPRPQADASTGMSPKQSPSAKRKPKPQLIDNEQLTHEMSYGTSDHA 506
            .|.|                    ..:|.|..                               ||
Mouse   468 LPDT--------------------CQSSCGHM-------------------------------HA 481

  Fly   507 LKMDVRKSPSLNSADSANKPTTDSSNPKLNLTLVTTTLAPLDKSVPSPKAPRTPATSPLKLFNPK 571
            |.:     |.:...| |.:.|....|.:      ||||..:.....||..|  |..  :::|.
Mouse   482 LVL-----PGVTRED-AGEITFSLGNSR------TTTLLRVKCVKHSPPGP--PVM--VEMFK-- 528

  Fly   572 PSGAPKDRSPVQPKPQPLPTPPMET-----------------------------------PDKAS 601
               ..|::..:..||   |.||.||                                   |.:..
Mouse   529 ---GQKNKVLLTWKP---PEPPPETSFIYRLERQEVGSDDWIQCFSIEKAGAVEVPGDCVPTEGD 587

  Fly   602 PNPKRSLSPPNKRQPPPLRKSPTPPEPIKVTPALLRSAEPVQL-------------GVNQNVRRF 653
            .:.:......:.|.|..:........|   |..|:...|.||:             .:.|.....
Mouse   588 YHFRICTVSEHGRSPHVVFNGSAHLVP---TARLVSGLEDVQVYDGEDAVFSLDLSAIIQGSWFL 649

  Fly   654 SGQTL---SPARNVPTLAL----------------AVA---SGVSAVIGEKLPTIEISAPPTPQE 696
            :|:.|   .|...|...||                ||.   ||  |::|...|.::.||..|.||
Mouse   650 NGEQLQSNEPEGQVEPGALRYRIEQKGLQHRLILQAVKHRDSG--ALVGFSCPGVQDSAALTIQE 712

  Fly   697 EEPPVLERSPSPEPAPKSQSNARRFSRSADKHDDVHTSNE------------FMLVVFDKNSKVK 749
            ....:|    ||:                ||.....|::|            |....:....||:
Mouse   713 SSVHIL----SPQ----------------DKVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVE 757

  Fly   750 DKDK-------------------QDSFELDLED---------AIQPPPISISAPDLAFLEFTNLH 786
            :.:.                   :||.|.:...         .:|.||:.|..|.    |...:|
Mouse   758 ESESLIVKTEGRKHRLILPEAQVRDSGEFECRTEGVSAFFGVTVQDPPVHIVNPQ----EHVFVH 818

  Fly   787 --TTFPLRRSVSSTELLYERAMARFY-EAVELEQAS---KSRKTSRDKLVTPVP----------- 834
              |:..:|   .:.|:..|.....:| :..|:|::.   ...|....:||.|..
Mouse   819 AITSECVR---LTCEVDREDTTVHWYKDGQEVEESDIIVLENKGPHHRLVLPAARPSDGGEFQCV 880

  Fly   835 --------------------------HQTPANLRKRL------------------GSISEAERLS 855
                                      |.....|.:.:                  ..:.|:..|.
Mouse   881 AGDERAYFTVTITDVFSWIVYPSSEVHVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALL 945

  Fly   856 FERRSEMRRQSADVVSISRKWDSRENV----NEMGNLT-----------------RIHTTG---- 895
            .|:...:||.....|.:.   ||.|.:    :|..:.|                 .:|...
Mouse   946 LEKEDTIRRLVLPSVQLE---DSGEYLCEIHDESASFTITVTEPPVRIIYPQDEVTLHAVSLECV 1007

  Fly   896 ---------QLPFETRKD---LRESEAEEEHEEGEEEHLTESTA--DDSEDMDLDYDED-----L 941
                     ..|....||   :.||||.....:|....|....|  :|..:...|..:|     :
Mouse  1008 VLTCELSREDAPVRWYKDGLEVEESEALVLQSDGPRRRLVLPAAQPEDGGEFVCDAGDDSAFFTV 1072

  Fly   942 DVDYPPQKKLQQQS-SNDL---GSDYTE-----STASSE----QDSIEKFKMELLARTRSPSPRD 993
            .|..||::.:...: |.||   ...:.|     :.|.|:    :|.:|....:.|........|.
Mouse  1073 TVTAPPERIVHPAARSLDLQFGAPGHVELRCEVAPAGSQVRWYKDGLEVEVSDALQLGAEGPART 1137

  Fly   994 LETYHPRTMGAGTFTPYRAPTPEQAAV----VLNRPVPLPSPDFVPKPI-------------LKR 1041
            |...|.:...||   .|...|.::|..    :...||...:|:..|.|:             |.|
Mouse  1138 LTLPHAQPEDAG---EYVCETRDEAVTFNVSLAELPVQFLAPEAAPNPLCVVPGEPVVLSCELSR 1199

  Fly  1042 SSNE-HMEQAVSPLPS----SFASEAP-TIIVPPTATVANSNPSTLKMDLAKGIKSFFSRDKRSA 1100
            :|.: ......||:..    ...:|.| .|:....|.:|::...|.:...:.|..|.
Mouse  1200 ASAQVFWSHNGSPVQQGEGLELRAEGPRRILCIQAADLAHTGVYTCQSGASPGAPSL-------- 1256

  Fly  1101 TEKNTEANEEISNPLERTNAAAIAADLEVKRKAKEEEELRRKEEERLMQEEAHAAVDHYSDLVKE 1165
                 ..|.:::.|..|. .|..||...|:.....:.||                |.|.|
Mouse  1257 -----SFNVQVAEPPVRV-VAPEAAQTSVRSTPGGDLEL----------------VVHLS----- 1294

  Fly  1166 VGSSHKYHTPL--YLD--------RDELKRAAAKAAAETDEEDMLTHAEELKKRRATGGSEDLFL 1220
                 :..||:  |.|        |.:|::|.|:              :.|:.|.|..|....:|
Mouse  1295 -----RPGTPVRWYKDGERLASQGRVQLEQAGAR--------------QVLRVRGARRGDAGEYL 1340

  Fly  1221 --APPVVRERRLSISEREQLVHVR--DAASSLAFHRSPEKPESDQEHESPKSQQDEEPEY---PT 1278
              ||   ::.|:.|...|:|..|:  ...:.|..|..     .|...:...|..|.|..:   ..
Mouse  1341 CDAP---QDSRIFIVSVEELPPVKLVSELTPLTVHEG-----DDATFQCEVSPPDAEVTWLRNGA 1397

  Fly  1279 VLVVPPPKSKNKNESETESVMSEMVEARPDARGRTRLVKVKRVIRRRVPSSTRSRDASLTRPAIA 1343
            |:...|              ..|||:   :...||.:::           ..:.:||.    .:.
Mouse  1398 VITAGP--------------QLEMVQ---NGSSRTLIIR-----------GCQLKDAG----TVT 1430

  Fly  1344 EVEGSQQTSLVLSAADRDLL 1363
            ...|:..||..|...:.:||
Mouse  1431 ARAGAADTSARLHVRETELL 1450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14964	NP_647779.2	FN3	29..127	CDD:238020	29/131 (22%)
		I-set	138..227	CDD:254352	28/97 (29%)
		Ig	155..224	CDD:143165	23/77 (30%)
		IG_like	243..323	CDD:214653	20/80 (25%)
		Ig	250..323	CDD:299845	19/73 (26%)
		FN3	327..411	CDD:238020	18/125 (14%)
Obsl1	XP_006496646.2	I-set	12..88	CDD:400151	22/95 (23%)
		Ig strand B	29..33	CDD:409353	1/3 (33%)
		Ig strand C	42..46	CDD:409353	2/6 (33%)
		Ig strand E	67..71	CDD:409353	0/3 (0%)
		Ig strand F	81..86	CDD:409353	1/4 (25%)
		IG	134..226	CDD:214652	26/91 (29%)
		Ig strand A'	252..257	CDD:409353	2/8 (25%)
		Ig	257..336	CDD:416386	20/78 (26%)
		Ig strand B	262..269	CDD:409353	0/6 (0%)
		Ig strand C	276..282	CDD:409353	2/5 (40%)
		Ig strand C'	283..286	CDD:409353	1/2 (50%)
		Ig strand D	292..298	CDD:409353	1/5 (20%)
		Ig strand E	301..311	CDD:409353	2/9 (22%)
		Ig strand F	315..323	CDD:409353	3/7 (43%)
		Ig strand G	325..336	CDD:409353	1/10 (10%)
		Ig	342..426	CDD:416386	14/90 (16%)
		Ig strand B	358..362	CDD:409353	0/3 (0%)
		Ig strand C	371..374	CDD:409353	0/2 (0%)
		Ig strand E	395..399	CDD:409353	0/3 (0%)
		Ig strand F	409..414	CDD:409353	0/4 (0%)
		Ig strand G	423..426	CDD:409353	0/2 (0%)
		FN3	518..602	CDD:238020	13/95 (14%)
		Ig	736..801	CDD:416386	6/64 (9%)
		Ig strand C	746..751	CDD:409353	0/4 (0%)
		Ig strand C'	754..757	CDD:409353	1/2 (50%)
		Ig strand D	762..767	CDD:409353	0/4 (0%)
		Ig strand E	770..775	CDD:409353	0/4 (0%)
		Ig strand F	784..790	CDD:409353	1/5 (20%)
		Ig strand G	793..801	CDD:409353	0/7 (0%)
		Ig	825..892	CDD:416386	10/69 (14%)
		Ig strand B	825..830	CDD:409353	1/7 (14%)
		Ig strand C	837..842	CDD:409353	0/4 (0%)
		Ig strand C'	845..848	CDD:409353	1/2 (50%)
		Ig strand D	853..858	CDD:409353	0/4 (0%)
		Ig strand E	861..866	CDD:409353	1/4 (25%)
		Ig strand F	875..881	CDD:409353	0/5 (0%)
		Ig strand G	884..892	CDD:409353	0/7 (0%)
		Ig	918..983	CDD:416386	11/67 (16%)
		Ig strand C	928..933	CDD:409353	0/4 (0%)
		Ig strand C'	936..939	CDD:409353	0/2 (0%)
		Ig strand D	944..949	CDD:409353	2/4 (50%)
		Ig strand E	952..957	CDD:409353	2/4 (50%)
		Ig strand F	966..972	CDD:409353	1/5 (20%)
		Ig strand G	975..983	CDD:409353	2/7 (29%)
		Ig	1009..1074	CDD:416386	13/64 (20%)
		Ig strand C	1019..1024	CDD:409353	1/4 (25%)
		Ig strand C'	1027..1030	CDD:409353	0/2 (0%)
		Ig strand D	1035..1040	CDD:409353	0/4 (0%)
		Ig strand E	1043..1048	CDD:409353	1/4 (25%)
		Ig strand F	1057..1063	CDD:409353	0/5 (0%)
		Ig strand G	1066..1074	CDD:409353	1/7 (14%)
		Ig	1096..1166	CDD:416386	14/72 (19%)
		Ig strand B	1099..1104	CDD:409353	1/4 (25%)
		Ig strand C	1111..1116	CDD:409353	0/4 (0%)
		Ig strand C'	1119..1122	CDD:409353	1/2 (50%)
		Ig strand D	1127..1132	CDD:409353	1/4 (25%)
		Ig strand E	1135..1140	CDD:409353	2/4 (50%)
		Ig strand F	1149..1155	CDD:409353	2/8 (25%)
		Ig strand G	1158..1166	CDD:409353	1/7 (14%)
		Ig	1179..1265	CDD:416386	16/98 (16%)
		Ig strand A	1179..1184	CDD:409353	2/4 (50%)
		Ig strand B	1188..1196	CDD:409353	0/7 (0%)
		Ig strand C	1202..1208	CDD:409353	0/5 (0%)
		Ig strand C'	1210..1213	CDD:409353	1/2 (50%)
Ig strand D	1218..1222	CDD:409353	0/3 (0%)
Ig strand E	1228..1235	CDD:409353	1/6 (17%)
Ig strand F	1241..1250	CDD:409353	1/8 (13%)
Ig strand G	1252..1265	CDD:409353	3/25 (12%)
Ig	1273..1354	CDD:416386	25/123 (20%)
Ig strand A	1273..1275	CDD:409353	0/1 (0%)
Ig strand A'	1278..1282	CDD:409353	1/3 (33%)
Ig strand B	1286..1292	CDD:409353	3/21 (14%)
Ig strand C	1299..1304	CDD:409353	1/4 (25%)
Ig strand C'	1307..1310	CDD:409353	0/2 (0%)
Ig strand D	1315..1320	CDD:409353	1/4 (25%)
Ig strand E	1323..1328	CDD:409353	1/18 (6%)
Ig strand F	1337..1343	CDD:409353	1/5 (20%)
Ig strand G	1346..1354	CDD:409353	2/7 (29%)
Ig	1361..1444	CDD:416386	19/119 (16%)
Ig strand B	1376..1383	CDD:409353	1/6 (17%)
Ig strand C	1389..1395	CDD:409353	1/5 (20%)
Ig strand C'	1396..1399	CDD:409353	0/2 (0%)
Ig strand D	1405..1410	CDD:409353	3/7 (43%)
Ig strand E	1413..1423	CDD:409353	2/20 (10%)
Ig strand G	1433..1444	CDD:409353	4/10 (40%)
Ig	1451..1522	CDD:416386	318/1710 (19%)
Ig strand A'	1458..1461	CDD:409353
Ig strand B	1465..1471	CDD:409353
Ig strand C	1480..1485	CDD:409353
Ig strand C'	1488..1491	CDD:409353
Ig strand D	1496..1501	CDD:409353
Ig strand E	1504..1509	CDD:409353
Ig strand F	1518..1524	CDD:409353
Ig strand G	1527..1535	CDD:409353
Ig	1543..1624	CDD:416386
Ig strand A'	1549..1552	CDD:409353
Ig strand B	1556..1562	CDD:409353
Ig strand C	1569..1574	CDD:409353
Ig strand C'	1577..1580	CDD:409353
Ig strand D	1585..1590	CDD:409353
Ig strand E	1593..1598	CDD:409353
Ig strand F	1607..1613	CDD:409353
Ig strand G	1616..1624	CDD:409353
Ig	1631..1714	CDD:416386
Ig strand B	1645..1651	CDD:409353
Ig strand C	1658..1663	CDD:409353
Ig strand C'	1666..1669	CDD:409353
Ig strand D	1674..1679	CDD:409353
Ig strand E	1682..1687	CDD:409353
Ig strand F	1696..1702	CDD:409353
Ig	1720..1803	CDD:416386
Ig strand A'	1725..1730	CDD:409353
Ig strand B	1735..1742	CDD:409353
Ig strand C	1746..1754	CDD:409353
Ig strand C'	1755..1758	CDD:409353
Ig strand D	1764..1769	CDD:409353
Ig strand E	1772..1782	CDD:409353
Ig strand G	1792..1803	CDD:409353
IG_like	1815..1893	CDD:214653
Ig strand B	1826..1830	CDD:409353
Ig strand C	1838..1842	CDD:409353
Ig strand E	1863..1867	CDD:409353
Ig strand F	1877..1882	CDD:409353
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0613
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900