DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14964 and spegb

DIOPT Version :9

Sequence 1:	NP_647779.2	Gene:	CG14964 / 38384	FlyBaseID:	FBgn0035410	Length:	1443	Species:	Drosophila melanogaster
Sequence 2:	XP_021334681.1	Gene:	spegb / 563174	ZFINID:	ZDB-GENE-081104-517	Length:	3608	Species:	Danio rerio

Alignment Length:	1031	Identity:	228/1031 - (22%)
Similarity:	353/1031 - (34%)	Gaps:	327/1031 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 QGGRPKKNVHWKSAER----------------PSPPGR---------PIL--------TPVAL-- 42
            :...|::.:.|....|                |.||..         |||        |..:|
Zfish  2669 EASAPRRRLSWALGRRGSQEKKEIEMMRLDGGPEPPPEPESKAPSESPILAMRKKIGSTMASLST 2733

  Fly    43 ------------------PEQQPDVVNLRWDRPLHDGGSPITGYTVEHRRMGSPHWVRATPTPVD 89
                              .::.|....||  |...:|||        .:|||.|
Zfish  2734 RIRSHSEDRKDDSEGKMETKRTPIFNKLR--RSTSEGGS--------LKRMGIP----------- 2777

  Fly    90 RCDVCISGLEPGWRYQFRCFAENIVGRSDASELSDPLTVTLQRNAITVPRFIDELVDTNAVEDER 154
                           |.:..|::  |:..:||..|.::.....:||           .||..|.|
Zfish  2778 ---------------QNQLAAQS--GQGTSSESLDSMSSIQSESAI-----------KNAELDRR 2814

  Fly   155 IEFRVRILGEPPPEINWFKDGYEIFSSRRTKIVNDNEASVLVIHQVALTDEGEIKCTATNRAGHV 219
                          ..|  |.:.:...::.|.|:                :.:|..:.....|.:
Zfish  2815 --------------SRW--DRWGLTRGKKDKTVS----------------QPDIPASIARENGSL 2847

  Fly   220 ITK--ARLMVQAPP----KIRLPRTYEDGLIVEADEVLRLKVGVAGQPPPAITWLHEGEVIAPGG 278
            .::  .||....||    |:|      |.:::|.|.| .|....||.|.|.|:|:.:.:.:....
Zfish  2848 RSRQYTRLTSDFPPVFHIKLR------DHVLLEGDPV-TLSCLPAGSPHPHISWMKDKKPLEIDP 2905

  Fly   279 RFE-VSNTEKNSLLKIDNVLREDRGEYMVKAWNRLGEDSTSFLVTVTARPNPPGTPKLNMSFGKS 342
            |.. :|..:...||.|....::|.|.|...|.|.|...::|.:|::...||.||||::...:..:
Zfish  2906 RMNMISCPDGRQLLMIMKTTKKDAGLYECVAANPLATVTSSCVVSLARLPNSPGTPEVPQKYKNT 2970

  Fly   343 ATLSW-----TAPLDDGGCKIGNYIVEYFRVGWNVWLKAATTRA-LSTTLHDLIEGSEYKFRVKA 401
            |.:.|     |||     |   .|.:|....|.|.||..||..| ....:.||..|:.|:|||..
Zfish  2971 ALVVWRPSDTTAP-----C---TYSLERKTEGENNWLIVATGVADCYYNVLDLPAGASYRFRVAC 3027

  Fly   402 ENPYGLSEPSGESELLFIPDPKRGITKPKSATRIAGDEKDKPKTGAGGMQVPPRRKTL-SPPRPQ 465
            .|..|....|..||::.:                   :..:|:..:|.:.|    ||| |.|.|.
Zfish  3028 VNKAGQGPYSSLSEVVVL-------------------DSTEPQKSSGTVVV----KTLSSAPAPA 3069

  Fly   466 ADASTGMSPKQSPSAKRKPKPQLIDNEQLTHEMSYGTSDHALKMDVRKSPSLNSADSANKPTTDS 530
            ...||...|...|:|                              ::.:||.|||.|..:|...:
Zfish  3070 VVTSTMTLPAMKPAA------------------------------IKPAPSTNSAPSTVQPVKPA 3104

  Fly   531 SNPKLNLTLVTTTLAPL-DKSVPSPKAPRTP--ATSPLKLFNPKPSGAPKDRSPVQPKPQPLPTP 592
            ..|..:    |.|..|: |...|||..| ||  |.|.|.:...|||.|.....| ||:|.|.|:|
Zfish  3105 PPPASS----TPTYRPVPDIRTPSPGTP-TPAKAKSTLNITMAKPSPASPAAQP-QPQPPPKPSP 3163

  Fly   593 PM-----ETPDKASPNPKRS--LSPPNKRQPPPLRKSPTPPEPIKVTPALLRSAEPVQLGVNQNV 650
            |:     :||......|.::  :|||....|||:...|....|:.| ||...|.....:.....|
Zfish  3164 PVILPKPQTPVSVVSPPSQTPPVSPPPLVSPPPIIGKPISSVPMYV-PATTTSTPVTPVTPVTPV 3227

  Fly   651 RRFSGQTLSPARNVPTLALAVASGVSAVIGEKLPTIEISAP---PTPQEEEPPVLERSPSPEPAP 712
            ...:..|.|||.:.|.:.:...|.|    ||...|.....|   .||.....|...|:|..:|..
Zfish  3228 TPVTPNTPSPALSPPVVLVTSLSPV----GEGTGTPNRMTPSGRATPSGRITPSGRRTPIGKPGD 3288

  Fly   713 KS-------------QSNAR-RFSRSADKHDDVHTSNEFM--LVVFDKNSKVKDKDKQDSFE--- 758
            .:             ...|| ||....:..::. |.|.:|  :|.::..||.....:.|..:
Zfish  3289 STLRQGVPQKPYTFMDEKARGRFGVIRECRENA-TGNLYMAKIVPYEPESKQTVLQEYDILKSLH 3352

  Fly   759 ----LDLEDAIQPPPISI---------------------SAPD--------LAFLEFTNLHTTFP 790
                :.|.:|...|...:                     |..|        |..|::  ||:
Zfish  3353 HEKIMALHEAYVTPRYLVLISECCSGKELLHSLIDRFRYSEDDVVAYIVQILQGLDY--LHS--- 3412

  Fly   791 LRRSVSSTELLYERAMARFYEAVELEQASKSRKTSRDKLVTPVPHQTPANLRKRLGSISEAERLS 855
              |.:...::..|..:..:...|::.....::..:            |..|::....|...:.:|
Zfish  3413 --RRILHLDIKPENIIVTYMNVVKIIDFGSAQTFN------------PLFLKQFSPPIGTLDYMS 3463

  Fly   856 FER-RSEMRRQSADVVSISRKWDSRENVNEMGNLTRIHTTGQLPFETRKDLRESEA 910
            .|. :.::....||:.||             |.||.|..:|:||| |..|..|:||
Zfish  3464 PEMLKGDVVGPPADIWSI-------------GILTYIMLSGRLPF-TENDPAETEA 3505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14964	NP_647779.2	FN3	29..127	CDD:238020	25/134 (19%)
		I-set	138..227	CDD:254352	12/90 (13%)
		Ig	155..224	CDD:143165	6/70 (9%)
		IG_like	243..323	CDD:214653	23/80 (29%)
		Ig	250..323	CDD:299845	21/73 (29%)
		FN3	327..411	CDD:238020	30/89 (34%)
spegb	XP_021334681.1	I-set	55..137	CDD:254352
		DUF4045	<228..687	CDD:330572
		I-set	781..870	CDD:254352
		I-set	928..1018	CDD:254352
		I-set	1029..1117	CDD:254352
		I-set	1123..1212	CDD:254352
		I-set	1249..1338	CDD:254352
		FN3	1343..1436	CDD:238020
		Ig	<1479..1541	CDD:325142
		I-set	1545..1634	CDD:254352
		PKc_like	1659..1913	CDD:328722
		I-set	2861..2949	CDD:254352	26/94 (28%)
		FN3	2955..3044	CDD:238020	33/96 (34%)
		PKc_like	3296..3552	CDD:328722	45/244 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0613
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900