DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14964 and Obsl1

DIOPT Version :9

Sequence 1:	NP_647779.2	Gene:	CG14964 / 38384	FlyBaseID:	FBgn0035410	Length:	1443	Species:	Drosophila melanogaster
Sequence 2:	XP_017452317.1	Gene:	Obsl1 / 363259	RGDID:	1306073	Length:	1897	Species:	Rattus norvegicus

Alignment Length:	1687	Identity:	321/1687 - (19%)
Similarity:	515/1687 - (30%)	Gaps:	618/1687 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 GGRPKKNVHWKSAERPSPPGRPILTPVALPE-QQPDVVNLRWDRPLHDGGSPITGYTVEHRRMGS 77
            ||.|:..::|:.            ..:||.| .......|..||...|||:.:|...:..|...|
  Rat   152 GGLPEPKLYWEK------------DGMALDEVWDSSHYTLEPDRGASDGGASLTLRILAARLPDS 204

  Fly    78 PHWVRATPTPVDRCDVCISGLEPGWRYQFRCFAENIVGRSDASEL-----------SDPLTVTLQ 131
            ..:|                          |.|.|..|.:.|..|           .||....:
  Rat   205 GVYV--------------------------CHARNAHGHAQAGALLQVHQPHENPPQDPDEPPV- 242

  Fly   132 RNAITVPRFIDELVDTNAV----EDERIEFRVRILGEPPPEINWFKDGYEIFSSRRTKIVNDNEA 192
                   |.|:.|......    |.:..:||..::|:|.|||.|..:|..:...||..:..|.:.
  Rat   243 -------RVIEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHLEGRPLLPDRRRLMYRDRDG 300

  Fly   193 S-VLVIHQVALTDEGEIKCTATNRAGHVITKARLMVQAPPKIRLPRTYEDGLIVEADE----VLR 252
            . ||.:......|.|...|.|.|.||..::..:|.|: .|::|..|..:|   ||..|    ||.
  Rat   301 GFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVK-EPRLRFTRPLQD---VEGREHGIVVLE 361

  Fly   253 LKVGVAGQPPPAITWLHEGEVIAPGGRFE---------------------------------VSN 284
            .||..:..|   ..|..|.:.:.|..::|                                 |:|
  Rat   362 CKVPNSRIP---TAWFREDQRLLPCRKYEQIEEGTVRRLVIHRLKADDDGVYLCEMRGRVRTVAN 423

  Fly   285 -TEKNSLLK---------------------------------------------------IDNVL 297
             |.|..:||                                                   :..|.
  Rat   424 VTVKGPILKRLPRKLDVLEGENAVLLVETQEAGVQGCWSRDGEELPATCQSSCGHMHALVLPGVT 488

  Fly   298 REDRGEYMVKAWNRLGEDSTSFLVTV-TARPNPPGTPKL-NMSFGKSAT--LSWTAPLDDGGCKI 358
            |||.||....    ||...|:.|:.| ..:.:|||.|.| .|..|:..|  |:|..|........
  Rat   489 REDAGEVTFS----LGNSRTTTLLRVKCVKHSPPGPPVLVEMFKGQKNTVLLTWKPPEPPPETSF 549

  Fly   359 GNYIVEYFRVGWNVWL------KAATTRALSTTLHDLI--EGSEYKFRVKAENPYGLSEP---SG 412
             .|.:|...||...|:      ||.......    |.:  || :|:||:...:.:|.|..   :|
  Rat   550 -IYRLERQEVGSEDWIQCFSIEKAGAVEVPG----DCVPTEG-DYRFRICTVSEHGRSPHVVFNG 608

  Fly   413 ESELLFIP--------------DPKRGITKPKSATRIAG-----------DEKD-KPKTGA---- 447
            .:.|  :|              |.:..:.....:|.|.|           ||.: :.:.||
  Rat   609 SAHL--VPTARLVSGLEDVQVYDGEDAVFSLDLSTIIQGSWFLNGELLKNDEAEGQVEPGALRYR 671

  Fly   448 ---GGMQVPPRRKTLSPPR------------PQADASTGMSPKQSPSAKRKPKPQLI------DN 491
               .|:|   .|..|...:            |....|..:|.::||.....|:.:::      :.
  Rat   672 IEQKGLQ---HRLILQTVKHQDNGALVGFICPGVQDSAALSIQESPVHILSPQDKVLLTFTTSER 733

  Fly   492 EQLTHEMS---------------YGTSDHALKMDVRKS----PSLNSADSAN-KPTTDSSNPKLN 536
            ..||.|:|               ..:....:|||.||.    |.....||.. :..|:..:...:
  Rat   734 VVLTCELSRVDFPATWYKDGQKVEESESLVVKMDGRKHRLILPEAQVRDSGEFECRTEGISAFFS 798

  Fly   537 LTLVTTTLAPLDKSVPSPKAPRTPATSPLKLFNPKPS---GAPKDRSPVQPKPQPLPTPPMETPD 598
            :|            |..|         |:.:.:|:..   .|....|       .:.|..::..|
  Rat   799 VT------------VQDP---------PVHIVDPQEHVFVHAITSES-------VMLTCEVDRED 835

  Fly   599 ------KASPNPKRSLSPPNKRQPPPLRKSPTPPEPIKVTPALLRSAEPVQLGVNQNVRRFSGQT 657
                  |.....:.|.....:::.|..|             .:|.:|:|...|..|.|
  Rat   836 AAVHWYKDGQEVEESAVIVLEKEGPRHR-------------LVLPAAQPSDGGEFQCV------- 880

  Fly   658 LSPARNVPTLALAVASG----------VSAVIGEKLP-TIEISAP-----PTPQEEEPPVLERSP 706
            :...|...|:.:...|.          |:||..|::. |.|:..|     .|...||  |||
  Rat   881 VGDERAYFTVTITDVSSWIVYPNGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEE--VLE--- 940

  Fly   707 SPEPAPKSQSNARRFSRSADKHDDVHTSNEFMLVVFDKNSKVKDKDKQDSFELDLEDAIQPPPIS 771
            ||....:.:...||....:.:.:|   |.|::..:.|:::         ||.:    .:..||:.
  Rat   941 SPALLLEKEDTIRRLVLPSVQLED---SGEYLCEIHDESA---------SFTI----TVTEPPVR 989

  Fly   772 ISAPDLAFLEFTNLHTTFPLRRSVSSTELLYERAMARFYEAVELEQASKSRKTSRDKLVTPVPHQ 836
            |..|.    :...||.. .|...|.:.||....|..|:|               :|.|
  Rat   990 IIYPQ----DEVTLHAV-SLECVVLTCELSRVDAPVRWY---------------KDGL------- 1027

  Fly   837 TPANLRKRLGSISEAERLSFERRSEMRRQSADVVSISRKWDSRENVNEMGNLTRIHT-TGQLPFE 900
                      .:.|.|.|..:.....||.   |:..::..|..|.|.:.|:.:...| |...|
  Rat  1028 ----------EVEETEALVLQSDGPRRRL---VLPAAQPEDGGEFVCDAGDDSAFFTVTVTAP-- 1077

  Fly   901 TRKDLRESEAEEEHEEGEEEHLTESTADDSEDMDLDYDEDLDVDYPPQKKLQQQSSNDLGSDYTE 965
                              .|.:....|   ..:||.:..      |...:|:.:          .
  Rat  1078 ------------------PERIVHPVA---RSLDLQFGA------PGHVELRCE----------V 1105

  Fly   966 STASSE----QDSIEKFKMELLARTRSPSPRDLETYHPRTMGAGTFTPYRAPTPEQAAV----VL 1022
            :.|.|:    :|.:|....:.|........|.|...|.:...||   .|...|.::|..    :.
  Rat  1106 APAGSQVRWYKDGLEVEVSDALQLGAEGPARTLTLPHAQPEDAG---EYVCETRDEAVTFNVSLA 1167

  Fly  1023 NRPVPLPSPDFVPKPILKRSSNEHMEQAVSPLPSSFASEAPTIIVPPTATVANSNPSTLKMDLAK 1087
            ..||...:|:.||.|:                          .:||       ..|..|..:|:
  Rat  1168 ELPVQFLAPEAVPNPL--------------------------CVVP-------GEPVMLSCELS- 1198

  Fly  1088 GIKSFFSRDKRSATEKNTEANEEISNPLERTNAAAIAADLEVKRKAKEEEELRRKEEERLMQEEA 1152
                      |::...:...|   .||:                |..|..|||.:...|::..:|
  Rat  1199 ----------RASAHVSWSHN---GNPV----------------KQGEGLELRAEGPRRILCIQA 1234

  Fly  1153 HAAVDHYSDLVKEVGSSHKYHTPLYLDRDELKRAAAKAA-----AETDEEDMLTHAEELKKRRAT 1212
                   :||.         ||.:|..:......|...:     ||.....:...|.:.:.|...
  Rat  1235 -------ADLA---------HTGVYTCQSGTAPGAPSLSFNVQVAEPPVRVVAPEAAQTRVRSTP 1283

  Fly  1213 GGSEDL--FLAPP------------VVRERRLSISE--REQLVHVRDAASSLAFHRSPEKPESDQ 1261
            ||..:|  .|:.|            :..:.|:.:.:  ..|::.||.|....|           .
  Rat  1284 GGDLELVVHLSRPGGPVRWYKDGERLASQGRVQLEQAGERQVLRVRGARRGDA-----------G 1337

  Fly  1262 EHESPKSQQD-------EEPEYPTVLVVPPPKSKNKNESETESVMSEMVEARPDARGRTRLVKVK 1319
            |:....||..       |||  |.|.:|........:|.:..:...|:  :.|||
  Rat  1338 EYLCDASQDSRIFIVSVEEP--PPVKLVSELTPLTVHEGDDATFQCEV--SPPDA---------- 1388

  Fly  1320 RVIRRRVPSSTRSRDASLTRPAIAEVEGSQQTSLVLSAADRDL------LQKAATLAIL--QSEE 1376
                    ..|..|:.::..|       ..|..:|.|.:.|.|      |:.|.|:...  .::.
  Rat  1389 --------EVTWLRNGAIVTP-------GPQLEMVHSGSSRTLIIRGCQLKDAGTVTARAGATDT 1438

  Fly  1377 QAHEKVRSALSYCTDLVLFLVACYVYLFKDARLVLPILGLIIYRQLGEAVRGYVPG---WLR 1435
            .|...||.     |:|:      ::...:|.|..   .|..:|.:: |..|...||   |||
  Rat  1439 SARLHVRE-----TELL------FLRRLQDVRAE---EGQDVYLEV-ETGRVGAPGAVRWLR 1485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14964	NP_647779.2	FN3	29..127	CDD:238020	21/109 (19%)
		I-set	138..227	CDD:254352	26/93 (28%)
		Ig	155..224	CDD:143165	21/69 (30%)
		IG_like	243..323	CDD:214653	28/168 (17%)
		Ig	250..323	CDD:299845	25/157 (16%)
		FN3	327..411	CDD:238020	26/97 (27%)
Obsl1	XP_017452317.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0613
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900