DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14964 and MYBPHL

DIOPT Version :9

Sequence 1:	NP_647779.2	Gene:	CG14964 / 38384	FlyBaseID:	FBgn0035410	Length:	1443	Species:	Drosophila melanogaster
Sequence 2:	NP_001010985.2	Gene:	MYBPHL / 343263	HGNCID:	30434	Length:	354	Species:	Homo sapiens

Alignment Length:	305	Identity:	86/305 - (28%)
Similarity:	129/305 - (42%)	Gaps:	62/305 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   227 VQAPPKIRLPRTYEDGLIVEADEVLRLKVGVAGQPPPAITWLHEGEVIAPGGRFEVSNTEKNSLL 291
            ::..|||.|||......|.:..:.:.|.:...|:|.|...|.|:|..: ...|..|.|.|::|:|
Human    47 IEEHPKIWLPRALRQTYIRKVGDTVNLLIPFQGKPKPQAIWTHDGCAL-DTRRVSVRNGEQDSIL 110

  Fly   292 KIDNVLREDRGEYMVKAWNRLG--EDSTSFLVTVTARPNPPGTPKLNMSFGKSATLSWTAPLDDG 354
            .|....|.|.|.|.::.  :||  |.:.:..:.|..||.||.:.||...:|.||||.||.|.|.|
Human   111 FIREAQRADSGRYQLRV--QLGGLEATATIDILVIERPGPPQSIKLVDVWGFSATLEWTPPQDTG 173

  Fly   355 GCKIGNYIVEYFRVGWNVWLKAATTRAL-----------STTLHDLIEGSEYKFRVKAENPYGLS 408
            ...:..|.|:          ||.|...|           |..:.|||.|:.|.|||.|||..|||
Human   174 NTALLGYTVQ----------KADTKSGLWFTVLEHYHRTSCIVSDLIIGNSYAFRVFAENQCGLS 228

  Fly   409 EPSG-ESELLFIPDPKRGITKPKSATRIAGDEKDKPKTGAGGMQVPPRRKTLSPPRPQADAS--T 470
            |.:. .::|..|   ::..|..|:......|..:.||.                .:|.||.:  |
Human   229 ETAPITTDLAHI---QKAATVYKTKGFAQRDFSEAPKF----------------TQPLADCTTVT 274

  Fly   471 GMSPKQSPSAKRKPKPQLIDNEQLTHEMSYGTSDHALKMDVRKSP 515
            |.:.:.....:..|:|::|..:.              |||::.:|
Human   275 GYNTQLFCCVRASPRPKIIWLKN--------------KMDIQGNP 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14964	NP_647779.2	FN3	29..127	CDD:238020
		I-set	138..227	CDD:254352	86/305 (28%)
		Ig	155..224	CDD:143165
		IG_like	243..323	CDD:214653	22/81 (27%)
		Ig	250..323	CDD:299845	21/74 (28%)
		FN3	327..411	CDD:238020	37/94 (39%)
MYBPHL	NP_001010985.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47		86/305 (28%)
		IG_like	61..142	CDD:214653	22/83 (27%)
		Ig	70..142	CDD:299845	21/74 (28%)
		FN3	146..235	CDD:238020	37/98 (38%)
		I-set	261..350	CDD:254352	14/75 (19%)
		Ig	280..344	CDD:143165	7/40 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000709
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000