DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14964 and Igfn1

DIOPT Version :9

Sequence 1:	NP_647779.2	Gene:	CG14964 / 38384	FlyBaseID:	FBgn0035410	Length:	1443	Species:	Drosophila melanogaster
Sequence 2:	XP_008767806.2	Gene:	Igfn1 / 304823	RGDID:	1565384	Length:	2699	Species:	Rattus norvegicus

Alignment Length:	557	Identity:	144/557 - (25%)
Similarity:	210/557 - (37%)	Gaps:	97/557 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 PSPPGRPILTPVALPEQQPDVVNLRWDRPLHDGGSPITGYTVEHRRMGSPHWVRATPTPVDRCDV 93
            |.||..|     |:.......:.|.|..|...|.:.|.||.||.|:.||..|:.....||.....
  Rat  2192 PGPPSAP-----AILSASSQSITLTWGAPQGPGSTHILGYLVEKRKKGSSTWMAVNEQPVSERRY 2251

  Fly    94 CISGLEPGWRYQFRCFAENIVG------RSDASELSDP---------LTVT-LQRNAITVPRFID 142
            .:..|..|.:|:||..|..:.|      .|||....||         |.|| ....:|||...:.
  Rat  2252 TVVDLRQGCQYEFRVMAVTLSGPGEPGPPSDAVFARDPMRPPGPVRDLQVTDTSDTSITVSWMVP 2316

  Fly   143 ELVDTNAVEDERIEFRVRILGEPPPEINWFKDGYE------------IFSSRRTKIVNDNEASVL 195
            :..|.    ||...:.|.:.|         .|.::            ||:::..:
  Rat  2317 DAQDA----DEAQGYIVELCG---------SDSHQWSPCHMGTVPGTIFTAKGLR---------- 2358

  Fly   196 VIHQVALTDEGE-IKCTATNRAGH-VITKARLMVQAPPKIRLPR-----TYEDGLIVEADEVLRL 253
                   ..||. ::.||.|..|. .......:|.|.|....||     :.:|.|:|...:.:|:
  Rat  2359 -------PQEGYFVRVTAVNDGGRSPAMSLDTLVHAMPATVCPRFLMDSSTKDTLMVRVGDSIRV 2416

  Fly   254 KVGVAGQPPPAITWLHEGEVIAPGGRFEVSNTEKNSL--LKIDNVLREDRGEYMVKAWNRLGEDS 316
            .|.....|.|.:|||.:|   .|..:..|: |.|:.|  |.|......|.|.|.|:..|..|:::
  Rat  2417 PVPFEAAPMPEVTWLKDG---LPLPKRSVT-TVKDGLTQLLIPVASLSDCGRYTVRLRNLHGKEA 2477

  Fly   317 T-SFLVTVTARPNPPGTPKLNMSFGKSATLSWTAPLDDGGCKIGNYIVEYFRVGWNVWLKAAT-T 379
            | ||.::|.|.|..||:..|..:...:.|:.|....|:......:|.|.........|.:.|. .
  Rat  2478 TYSFFISVAACPQAPGSIYLQENVPGTVTVQWEPSPDEAQGTPLHYTVLMRSSSHGSWHEVADYV 2542

  Fly   380 RALSTTLHDLIEGSEYKFRVKAENPYGLSEPSGESELLFIPDPKRGITKPKSATRIAGDEKDKPK 444
            |....||..::.|.||.|||.|:|..|.|:||..|:...|| .:|.....||.|....|...||:
  Rat  2543 RTNRFTLLGVLPGHEYHFRVLAKNELGASKPSDTSQPWCIP-KQRDRFSVKSPTYREPDLSQKPR 2606

  Fly   445 TGAGGMQVPPRRKTLSPPRPQADASTGMSPKQSPSAKRKPKPQL--IDNEQLTHEMSYGTSDHAL 507
            ...|      .|..|.|        .|...:.:.:.:..|:||:  ..|:|.........|...|
  Rat  2607 FLVG------LRAHLLP--------QGCECRMTCAVQGSPQPQVTWFKNDQSLDSNPAMYSTDLL 2657

  Fly   508 KMDVRKSPSLNSADSANKPTTDSSNPKLNLTLVTTTL 544
            .:.....||::..||...... :.|| |...:.|.||
  Rat  2658 GVCSLIIPSVSPKDSGEYKAV-AKNP-LGQAISTATL 2692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14964	NP_647779.2	FN3	29..127	CDD:238020	32/112 (29%)
		I-set	138..227	CDD:254352	14/102 (14%)
		Ig	155..224	CDD:143165	11/82 (13%)
		IG_like	243..323	CDD:214653	26/82 (32%)
		Ig	250..323	CDD:299845	24/75 (32%)
		FN3	327..411	CDD:238020	24/84 (29%)
Igfn1	XP_008767806.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0613
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900