DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14964 and Fndc3b

DIOPT Version :9

Sequence 1:	NP_647779.2	Gene:	CG14964 / 38384	FlyBaseID:	FBgn0035410	Length:	1443	Species:	Drosophila melanogaster
Sequence 2:	NP_001178633.1	Gene:	Fndc3b / 294925	RGDID:	1311673	Length:	1207	Species:	Rattus norvegicus

Alignment Length:	632	Identity:	131/632 - (20%)
Similarity:	212/632 - (33%)	Gaps:	236/632 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 SAERPSPPGRPILT-PVALPEQQPDVVNLRWDRPLHDGGSPITGYTVEHRRMGSPHWVRATPTPV 88
            |.:||.||.||:|. ||.     ....:::||.|..:|||.|..|.:|         :....:..
  Rat   571 SPDRPGPPTRPLLKGPVT-----SHGFSVKWDAPKDNGGSEILKYLLE---------ITDGASEA 621

  Fly    89 DRCDVCISG---------LEPGWRYQFRCFAENIVGRSDASELSDPLTVTLQRNAITVPRFIDEL 144
            .:.:|..||         |:||..|:.|.......|.|..||.....|::|.......|
  Rat   622 GQWEVAYSGSATEYVFTHLKPGTLYKLRACCIGTGGHSQCSESLPVRTLSLAPGQCRPP------ 680

  Fly   145 VDTNAVEDERIEFRVRILGEPPPE---INW----FKDGYEIFSSRRTKIVNDNEASVLVIHQVAL 202
                           |:||.|..:   :.|    .:.|.|: |....::....|.:..|.|
  Rat   681 ---------------RVLGRPKHKEVHLEWDVPASEGGCEV-SEYSVEMTEPEEVASEVYH---- 725

  Fly   203 TDEGEIKCTATNRAGHVITKARLMVQAPPKIRLPRTYEDGLIVEADEVLRLKVGVAGQPP----- 262
              ..|::||..|.....:.:.|:           |...||......:|  .::..|..||
  Rat   726 --GPELECTVGNLLPGTVYRFRV-----------RALNDGGYGPYSDV--SEITTAAGPPGQCRA 775

  Fly   263 PAITWLHEGEVI-------APGG-----RFEVSNTEK---------NSLLKIDNVLREDRGEYMV 306
            |.:::..:|.|:       :||.     |.|....|:         ::..:|.::|...:....:
  Rat   776 PCVSFTPDGCVLVGWESPESPGADISEFRLEWGEDEESLELIYHGPDTCFEIRDLLPAAQYCCRL 840

  Fly   307 KAWNRLGEDSTSFLV---TVTARPNPPGT---------------PKLNMSFGKSATLSWTAPLDD 353
            :|:|..|....|.||   |..:.|:|..|               |.:.:      .|:|..|
  Rat   841 QAFNPAGAGPYSELVHCQTPASAPDPVSTLCVLEEEPLSAHLDSPSVCL------VLTWEEP--- 896

  Fly   354 GGCKIGNYIVEYFRVGWNVWLKAATTRALSTTLH---DLIEGSEYKFRVKAENPYGLSEPSGESE 415
              |..|:.|:.|     |:.|........:||.|   :|:..:.|:.|::|.|..| ..|..:
  Rat   897 --CSNGSEIIAY-----NIDLGDTCITVGNTTTHVLKNLLPETTYRIRIQAVNDIG-DGPFSQ-- 951

  Fly   416 LLFIPDPKRGITKPKSATRIAGDEKDKPKTGAGGMQVPPRRKTLSPPRPQADASTGMSPKQSPSA 480
              ||          |:.||                .:||     ||||.:..||
  Rat   952 --FI----------KAKTR----------------PLPP-----SPPRLECAAS----------- 972

  Fly   481 KRKPKPQLI------DNEQL--THEMSYGTSDHALKMDVR--------KSPSLN----------- 518
                .||.:      .|.::  .|:|.|     .|:::.|        :.||..
  Rat   973 ----GPQSLKLKWGDSNSKIHAAHDMVY-----TLQLEDRNKRFISIYRGPSHTYKVQRLTEFTC 1028

  Fly   519 -------SADSANKPTTDSSNPKLNLTLVTTTLAPLDKSVPSPKAPR 558
                   ::::...|.:|:      .|..||...|     |:.||||
  Rat  1029 YSFRIQATSEAGEGPFSDT------YTFSTTKSVP-----PTLKAPR 1064

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14964	NP_647779.2	FN3	29..127	CDD:238020	29/107 (27%)
		I-set	138..227	CDD:254352	17/95 (18%)
		Ig	155..224	CDD:143165	15/75 (20%)
		IG_like	243..323	CDD:214653	20/108 (19%)
		Ig	250..323	CDD:299845	20/101 (20%)
		FN3	327..411	CDD:238020	22/101 (22%)
Fndc3b	NP_001178633.1	FN3	283..377	CDD:238020
		FN3	382..473	CDD:238020
		FN3	481..570	CDD:238020
		FN3	575..669	CDD:238020	29/107 (27%)
		FN3	674..765	CDD:238020	21/131 (16%)
		FN3	770..859	CDD:238020	17/88 (19%)
		fn3	889..950	CDD:394996	19/77 (25%)
		FN3	973..1052	CDD:238020	13/89 (15%)
		FN3	1057..1130	CDD:238020	6/13 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0613
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900