DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14964 and Egflam

DIOPT Version :9

Sequence 1:	NP_647779.2	Gene:	CG14964 / 38384	FlyBaseID:	FBgn0035410	Length:	1443	Species:	Drosophila melanogaster
Sequence 2:	NP_001276425.1	Gene:	Egflam / 268780	MGIID:	2146149	Length:	1017	Species:	Mus musculus

Alignment Length:	369	Identity:	81/369 - (21%)
Similarity:	129/369 - (34%)	Gaps:	117/369 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 GEIKCTA-------TNRAGHVITKARLMVQAPPKIRLPRTYEDGLIVEADEVLRLKVGVAGQPPP 263
            |.:.|||       ..|:|..|            |.....|.:   |.:|:.||.:   :...|.
Mouse    44 GALNCTAFSIQWKTPKRSGSSI------------IGYTVFYSE---VGSDKSLRER---SHNVPV 90

  Fly   264 AITWLHEGEVIA---PGGRFEVSNTEKNSLLKIDNVLREDRGEYMVKAWNRLGEDSTSFLVTVTA 325
            ....|...|||.   ||..::||                      |.|:::.|:...||...||.
Mouse    91 GQDTLITEEVIGDLKPGTEYQVS----------------------VAAYSQTGKGRLSFPRHVTT 133

  Fly   326 -------RPNPPGTPKLNMSFGKSATLSWTAPLDDGGCKIGNYIVEYFR----VGWNVWLKAATT 379
                   .|..|..|.:.:.......|||....::|...|.:|.||:.|    ..|.:..:  ..
Mouse   134 LSQDSCLPPAAPQQPHVLVVSDSEVALSWRPGENEGSAPIQSYSVEFIRPDFDKSWTIIQE--RL 196

  Fly   380 RALSTTLHDLIEGSEYKFRVKAENPYGLSEPSGESELL----------------FIPDPKRGIT- 427
            :..|..:..|...:.|:|.|||.|.:|.|..|..|..:                :|.:|  |::
Mouse   197 QMDSMVIKGLDPDTNYQFAVKAMNAHGFSPRSWPSNTVRTLGPGEAGSGHYGPGYITNP--GVSE 259

  Fly   428 ------------------KPKSATRIAGDEK---DKPKTGAGGMQVPPRRKTLSPPRPQADASTG 471
                              ||..||:: |::|   :..||......:..|   |:.|...:...|.
Mouse   260 DDDGSEDELDLDVSFEEVKPLPATKV-GNKKFSVESKKTSVSNSVMGSR---LAQPTSASLHETT 320

  Fly   472 MSPKQSPSAKRKPK------PQLID---NEQLTHEMSYGTSDHA 506
            ::...:| |:||.|      .:|.|   :|.|....|:..:|:|
Mouse   321 VAIPPTP-AQRKGKNSVAMMSRLFDMSCDETLCSADSFCVNDYA 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14964	NP_647779.2	FN3	29..127	CDD:238020
		I-set	138..227	CDD:254352	7/27 (26%)
		Ig	155..224	CDD:143165	7/24 (29%)
		IG_like	243..323	CDD:214653	18/82 (22%)
		Ig	250..323	CDD:299845	16/75 (21%)
		FN3	327..411	CDD:238020	23/87 (26%)
Egflam	NP_001276425.1	FN3	36..133	CDD:238020	28/128 (22%)
		FN3	142..236	CDD:238020	25/95 (26%)
		LamG	391..541	CDD:238058
		EGF_CA	560..602	CDD:238011
		LamG	618..765	CDD:238058
		EGF_CA	790..820	CDD:238011
		Laminin_G_2	868..993	CDD:280389
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0613
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900