DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14964 and OBSL1

DIOPT Version :9

Sequence 1:	NP_647779.2	Gene:	CG14964 / 38384	FlyBaseID:	FBgn0035410	Length:	1443	Species:	Drosophila melanogaster
Sequence 2:	XP_011509159.1	Gene:	OBSL1 / 23363	HGNCID:	29092	Length:	1918	Species:	Homo sapiens

Alignment Length:	1483	Identity:	288/1483 - (19%)
Similarity:	444/1483 - (29%)	Gaps:	518/1483 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 SAERPSPP-----GRPI---------LTPVALPEQQPDVVNLRWDRPLHDGGSPITGYTVEHRRM 75
            |.::.|||     .||:         |..|.|.|..|.||   |::    ||..:..    ..|:
Human     5 SGDQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVV---WEK----GGQQLAA----SERL 58

  Fly    76 -----GSPHWVRATPT-PVDRCDVCISGLEPGWRYQFRCFAENIVGRSDAS--------ELSDPL 126
                 |:.|.:..|.. |.|      :|:       :.|.|.|..|.:.|:        ..|||.
Human    59 SFPADGAEHGLLLTAALPTD------AGV-------YVCRARNAAGEAYAAAAVTVLEPPASDPE 110

  Fly   127 TVTLQR------NAITVPRFIDELVDTNAVEDERIEFRVRILGEPPPEINWFKDGY---EIFSSR 182
            ....:|      :....|.|:........:....:....|..|.|.|.:.|.|||.   |::.|.
Human   111 LQPAERPLPSPGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSS 175

  Fly   183 RTKI----VNDNEASVLVIHQVA--LTDEGEIKCTATNRAGHVITKARLMVQAPPKIR------- 234
            ...:    ..|...:.|.:..:|  |.|.|...|.|.|..||....|.|.|..||:..
Human   176 HFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEA 240

  Fly   235 ----------LPRTYEDGLIVEADEVLRLKVGVAGQPPPAITWLHEGEVIAPG-GRFEVSNTEKN 288
                      .|:|:    .|...:..:.:..|.|:|.|.|.|..||..:.|. .|....:.:..
Human   241 PAPVVEPLKCAPKTF----WVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGG 301

  Fly   289 SLLKIDNVLREDRGEYMVKAWNRLGEDSTSFLVTVTARPNPPGTPKLNMSFGKSATLSWTAPLDD 353
            .:||:.....:|||.|:..|.|..|:..::..:.|                 |...|.:|.||.|
Human   302 FVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHV-----------------KEPRLRFTRPLQD 349

  Fly   354 G----------GCKIGNYIVEYFRVGWNVWLKAATTRALSTTLHDLIEGSEYK----FRVKAEN- 403
            .          .||:.|..:.      ..|.: ...|.|....::.||....:    .|:||::
Human   350 VEGREHGIAVLECKVPNSRIP------TAWFR-EDQRLLPCRKYEQIEEGTVRRLIIHRLKADDD 407

  Fly   404 ---------------------------PYGLSEPSGESELLFIPDPKRGITKPKSATRIAGDEKD 441
                                       |..|....||:.:|.:...:.|:     ..|.:.|.::
Human   408 GIYLCEMRGRVRTVANVTVKGPILKRLPRKLDVLEGENAVLLVETLEAGV-----EGRWSRDGEE 467

  Fly   442 KP---KTGAGGMQVPPRRKTLSPPRPQADASTGMSPKQSPSAKRKPKPQLIDNEQLTHEMSYGTS 503
            .|   ::.:|.|
Human   468 LPVICQSSSGHM----------------------------------------------------- 479

  Fly   504 DHALKMDVRKSPSLNSADSANKPTTDSSNPKLNLTLVTTTLAPLDKSVPSPKAPRTPATSPLKLF 568
             |||.:     |.:...| |.:.|....|.:      ||||..:.....||
Human   480 -HALVL-----PGVTRED-AGEVTFSLGNSR------TTTLLRVKCVKHSP-------------- 517

  Fly   569 NPKPSGAPKDRSPVQPKPQPLPTPPMETPDKASPNPKRSLSPPNKRQPPPLRKSPTPPEPIKVTP 633
                                 |.||:             |:...|.....:..:..||||...||
Human   518 ---------------------PGPPI-------------LAEMFKGHKNTVLLTWKPPEPAPETP 548

  Fly   634 ALLRSAEPVQLGVNQNVRRF----------------------------SGQTLSP-------ARN 663
            .:.| .|..::|....::.|                            ||...||       |..
Human   549 FIYR-LERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHL 612

  Fly   664 VPTLALA-------VASGVSAVIGEKLPTI----------EISAPPTPQEEEPPVLERSPSPEPA 711
            |||..|.       |..|..||....|.||          |:.:.....:.||..|..      .
Human   613 VPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQGTWFLNGEELKSNEPEGQVEPGALRY------R 671

  Fly   712 PKSQSNARRFSRSADKHDDVHTSNEFMLVVFDKNSKVKDKDKQDSFELDLEDAIQPPPISISAP- 775
            .:.:....|....|.||.|     ...||.|      .....|||..|    .||..|:.|.:|
Human   672 IEQKGLQHRLILHAVKHQD-----SGALVGF------SCPGVQDSAAL----TIQESPVHILSPQ 721

  Fly   776 DLAFLEFTNLHTTFPLRRSVSSTELLYERAMARFYEAVELEQASKSRKTSRDKLVTPVPHQTPAN 840
            |...|.||.      ..|.|.:.||......|.:|:        ..:|....:|:.     ...:
Human   722 DRVSLTFTT------SERVVLTCELSRVDFPATWYK--------DGQKVEESELLV-----VKMD 767

  Fly   841 LRKRLGSISEA---ERLSFERRSE-------MRRQSADVVSISRKWDSRENVNEMGNLTRIHT-T 894
            .||....:.||   :...||.|:|       :..|...|..:    |.||:|       .:|. |
Human   768 GRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIV----DPREHV-------FVHAIT 821

  Fly   895 GQLPFETRKDLRESEAEEEHEEGEEEHLTESTADDSEDMDLDYDEDLDVDYPPQKKLQQQSSNDL 959
            .:......:..||......:::|:|       .::|:.:.|:.:       .|.::|...::...
Human   822 SECVMLACEVDREDAPVRWYKDGQE-------VEESDFVVLENE-------GPHRRLVLPATQPS 872

  Fly   960 GSDYTESTASSEQDSIEKFKMELLARTRSPSPRDLETYHPRTM-GAGTFTPYRAPTPEQAAVVLN 1023
            .....:..|..|.                       .|...|: ...::..|.:.....|||.|.
Human   873 DGGEFQCVAGDEC-----------------------AYFTVTITDVSSWIVYPSGKVYVAAVRLE 914

  Fly  1024 RPVPLPSPDFVPKPILKRSSNEHMEQAVSPLPSSFASEAPTI--IVPPTATVANSNPSTLKMDLA 1086
            |.|....   :.:|..:....:..|:.|.. |:....:..|:  :|.|...:.:|.....::|
Human   915 RVVLTCE---LCRPWAEVRWTKDGEEVVES-PALLLQKEDTVRRLVLPAVQLEDSGEYLCEID-- 973

  Fly  1087 KGIKSFFSRDKRSATEKNTEANEEISNPLERTNAAAIAADLEVKRKAKEEEELRRKEEERLMQEE 1151
                    .:..|.|...||....|..|.:.....|:..:..|...     ||.|::
Human   974 --------DESASFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMC-----ELSRED-------- 1017

  Fly  1152 AHAAVDHYSDLVKEVGSSHKYHTPLYLDRDELK-RAAAKAAAETDEEDMLTHAEELKKRRATGGS 1215
              |.|..|.|.: ||..|.    .|.|:||..: |....||...|..:.:..|          |.
Human  1018 --APVRWYKDGL-EVEESE----ALVLERDGPRCRLVLPAAQPEDGGEFVCDA----------GD 1065

  Fly  1216 EDLFL-----APPVVRERRLSISEREQLVHVRDAASSLAFH---------RSPEKPESDQ----- 1261
            :..|.     |||            |::||  .||.||..|         |....|...|
Human  1066 DSAFFTVTVTAPP------------ERIVH--PAARSLDLHFGAPGRVELRCEVAPAGSQVRWYK 1116

  Fly  1262 ---EHESPKSQQ--DEEPEYPTVLVVPPPKSKNKNESET--ESVMSEMVEARP 1307
               |.|:..:.|  .|.|.....|....|:...:...||  |::...::.|.|
Human  1117 DGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEP 1169

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14964	NP_647779.2	FN3	29..127	CDD:238020	30/125 (24%)
		I-set	138..227	CDD:254352	25/97 (26%)
		Ig	155..224	CDD:143165	21/77 (27%)
		IG_like	243..323	CDD:214653	20/80 (25%)
		Ig	250..323	CDD:299845	19/73 (26%)
		FN3	327..411	CDD:238020	19/125 (15%)
OBSL1	XP_011509159.1	IG_like	18..101	CDD:214653	24/106 (23%)
		IGc2	25..88	CDD:197706	19/86 (22%)
		IG	134..226	CDD:214652	23/91 (25%)
		IGc2	142..216	CDD:197706	19/73 (26%)
		IG	252..336	CDD:214652	22/87 (25%)
		Ig	252..336	CDD:299845	22/87 (25%)
		I-set	342..426	CDD:254352	15/90 (17%)
		Ig	358..421	CDD:143165	11/69 (16%)
		IG_like	435..510	CDD:214653	23/145 (16%)
		FN3	518..602	CDD:238020	17/97 (18%)
		IG	725..802	CDD:214652	19/95 (20%)
		Ig	734..802	CDD:143165	15/80 (19%)
		Ig	825..893	CDD:143165	12/104 (12%)
		Ig	916..984	CDD:143165	12/81 (15%)
		IG	1005..1074	CDD:214652	22/98 (22%)
		Ig	1007..1075	CDD:143165	22/97 (23%)
		IG_like	1097..1154	CDD:214653	10/56 (18%)
		IGc2	1099..1159	CDD:197706	12/59 (20%)
		Ig_Semaphorin_C	1178..1267	CDD:143180
		IG	1180..1262	CDD:214652
		IG	1282..1343	CDD:214652
		IGc2	1283..1341	CDD:197706
		I-set	1361..1444	CDD:254352
		ig	1364..1430	CDD:278476
		IG_like	1456..1535	CDD:214653
		Ig	1481..1536	CDD:143165
		I-set	1541..1624	CDD:254352
		I-set	1631..1714	CDD:254352
		Ig	1635..1724	CDD:299845
		I-set	1725..1803	CDD:254352
		Ig	1814..1893	CDD:299845
		IG_like	1815..1893	CDD:214653
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0613
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900