DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14964 and Igfn1

DIOPT Version :9

Sequence 1:	NP_647779.2	Gene:	CG14964 / 38384	FlyBaseID:	FBgn0035410	Length:	1443	Species:	Drosophila melanogaster
Sequence 2:	NP_808310.2	Gene:	Igfn1 / 226438	MGIID:	3045352	Length:	2849	Species:	Mus musculus

Alignment Length:	570	Identity:	147/570 - (25%)
Similarity:	212/570 - (37%)	Gaps:	123/570 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 PSPPGRPILTPVALPEQQPDVVNLRWDRPLHDGGSPITGYTVEHRRMGSPHWVRATPTPVDRCDV 93
            |.||..|     |:.......:.|.|..|...|.:.|.||.:|..:.||..|:.....||.....
Mouse  2342 PGPPSAP-----AILSASSQSITLTWGAPQGPGSNHILGYLIEKHKKGSNTWMAVNEQPVSERRY 2401

  Fly    94 CISGLEPGWRYQFRCFAENIVG------RSDASELSDP---------LTVTLQRN-AITVPRFID 142
            .:.||..|.:|:||..|..:.|      .|||....||         |.||...| :|||...:.
Mouse  2402 TVVGLRQGCQYEFRVTAVTLSGPGDPGPPSDAVFARDPMRPPGPVRDLQVTDTSNTSITVSWMVP 2466

  Fly   143 ELVDTNAVEDERIEFRVRILGEPPPEINWF-------------------KDGYEIFSSRRTKIVN 188
            :..|.    ||...:.|.:.|....:  |.                   ::||.:    |...||
Mouse  2467 DARDA----DEAQGYIVELCGSDSHQ--WSPCHVGTVPGTTFTAKGLRPQEGYFV----RVTAVN 2521

  Fly   189 D---NEASVL--VIHQVALT-------DEGEIKCTATNRAGHVITKARLMVQAPPKIRLPRTYED 241
            |   ::|:.|  ::|.:..|       |.|              ||..|||:....||:|.::|
Mouse  2522 DGGRSQATSLDTLVHAMPATVCPRFLMDSG--------------TKDTLMVRVGDSIRVPLSFE- 2571

  Fly   242 GLIVEADEVLRLKVGVAGQPPPAITWLHEGEVIAPGGRFEVSNTEKNSL--LKIDNVLREDRGEY 304
                             ..|.|.:|||.:|   .|..:..|: |.|..|  |.|......|.|.|
Mouse  2572 -----------------AAPMPEVTWLKDG---LPLPKRSVT-TVKAGLTQLLIPAASLSDCGRY 2615

  Fly   305 MVKAWNRLGEDST-SFLVTVTARPNPPGTPKLNMSFGKSATLSWTAPLDDG-GCKIGNYIVEYFR 367
            .|...|..|:::| ||.:.|.|.|..||:..|..:...:.|:.|....|:. |..: :|.|....
Mouse  2616 TVMLRNLQGKEATHSFFINVAACPQAPGSIYLQENVPGTVTVQWEPSPDEAQGIPL-HYTVLMRS 2679

  Fly   368 VGWNVWLKAAT-TRALSTTLHDLIEGSEYKFRVKAENPYGLSEPSGESELLFIPDPKRGITKPKS 431
            .....|.:.|. .|....||..::.|.||.|||.|:|..|:|:||..|:...||..:...| .||
Mouse  2680 SSHRSWHEVADHVRTNRFTLLGVLPGHEYHFRVLAKNELGVSKPSDTSQPWCIPRQRDRFT-VKS 2743

  Fly   432 ATRIAGDEKDKPKTGAGGMQVPPRRKTLSPPRPQADASTGMSPKQSPSAKRKPKPQL--IDNEQL 494
            .|....|...||:...|      .|..|.|        .|...:.:.:.:..|:|.:  ..|:|.
Mouse  2744 PTYQDPDLSQKPRFLVG------LRAHLLP--------QGCECRMTCAVQGSPQPHVTWFKNDQS 2794

  Fly   495 THEMSYGTSDHALKMDVRKSPSLNSADSANKPTTDSSNPKLNLTLVTTTL 544
            ........|...|.:.....||::..||...... :.|| |...:.|.||
Mouse  2795 LDRNPAVYSTDLLGVCSLVIPSVSLKDSGEYKAV-AKNP-LGQAVSTATL 2842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14964	NP_647779.2	FN3	29..127	CDD:238020	31/112 (28%)
		I-set	138..227	CDD:254352	21/119 (18%)
		Ig	155..224	CDD:143165	17/99 (17%)
		IG_like	243..323	CDD:214653	22/82 (27%)
		Ig	250..323	CDD:299845	22/75 (29%)
		FN3	327..411	CDD:238020	25/85 (29%)
Igfn1	NP_808310.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	82..108
		I-set	187..278	CDD:254352
		Ig	204..278	CDD:299845
		IG_like	467..554	CDD:214653
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	577..600
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	652..760
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	864..924
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	962..981
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1061..1103
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1221..1258
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1312..1338
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1350..1384
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1498..1523
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1654..1675
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1724..1780
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1827..2055
		I-set	2055..2138	CDD:254352
		IG_like	2154..2238	CDD:214653
		Ig	2163..2238	CDD:299845
		FN3	2242..2334	CDD:238020
		FN3	2342..2434	CDD:238020	28/96 (29%)
		FN3	2443..2530	CDD:238020	20/96 (21%)
		IG_like	2555..2635	CDD:214653	29/101 (29%)
		Ig	2563..2635	CDD:299845	26/93 (28%)
		FN3	2639..2728	CDD:238020	27/89 (30%)
		I-set	2755..2844	CDD:254352	22/104 (21%)
		Ig	2773..2841	CDD:143165	14/69 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0613
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900