DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14964 and EGFLAM

DIOPT Version :9

Sequence 1:	NP_647779.2	Gene:	CG14964 / 38384	FlyBaseID:	FBgn0035410	Length:	1443	Species:	Drosophila melanogaster
Sequence 2:	NP_001192230.1	Gene:	EGFLAM / 133584	HGNCID:	26810	Length:	1017	Species:	Homo sapiens

Alignment Length:	297	Identity:	64/297 - (21%)
Similarity:	106/297 - (35%)	Gaps:	96/297 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   272 EVIA---PGGRFEVSNTEKNSLLKIDNVLREDRGEYMVKAWNRLGEDSTSFLVTVTA-------R 326
            |||.   ||..:.||                      :.|:::.|:...|....||.       .
Human    99 EVIGDLKPGTEYRVS----------------------IAAYSQAGKGRLSSPRHVTTLSQDSCLP 141

  Fly   327 PNPPGTPKLNMSFGKSATLSWTAPLDDGGCKIGNYIVEYFRVGWN-VWLKAATTRALSTTLHDLI 390
            |..|..|.:.:.......|||.....:|...|..|.||:.|..:: .|          |::|:.|
Human   142 PAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKW----------TSIHERI 196

  Fly   391 E-----------GSEYKFRVKAENPYGLSEPSGESELLFIPDPKR---GITKPKSATRIAGDEKD 441
            :           .:.|:|.|:|.|.:|.|..|..|:::....|:.   |...|:..|.:...|.|
Human   197 QMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCPEEAGSGRYGPRYITDMGAGEDD 261

  Fly   442 K------------------PKTGAGGMQ--VPPRRKTLSPPR------PQADAS---TGMSPKQS 477
            :                  |.|..|..:  |..::.::|.|:      |...||   |.::|:..
Human   262 EGFEDDLDLDISFEEVKPLPATKGGNKKFLVESKKMSISNPKTISRLIPPTSASLPVTTVAPQPI 326

  Fly   478 PSAKRKPK------PQLID---NEQLTHEMSYGTSDH 505
            | .:||.|      .:|.|   :|.|....|:..:|:
Human   327 P-IQRKGKNGVAIMSRLFDMPCDETLCSADSFCVNDY 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14964	NP_647779.2	FN3	29..127	CDD:238020
		I-set	138..227	CDD:254352
		Ig	155..224	CDD:143165
		IG_like	243..323	CDD:214653	10/53 (19%)
		Ig	250..323	CDD:299845	10/53 (19%)
		FN3	327..411	CDD:238020	23/95 (24%)
EGFLAM	NP_001192230.1	FN3	36..133	CDD:238020	11/55 (20%)
		FN3	142..234	CDD:238020	25/101 (25%)
		LamG	391..541	CDD:238058
		EGF_CA	560..602	CDD:238011
		LamG	618..765	CDD:238058
		EGF_CA	<792..820	CDD:238011
		Laminin_G_2	868..993	CDD:280389
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0613
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900