DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14964 and AgaP_AGAP005471

DIOPT Version :9

Sequence 1:	NP_647779.2	Gene:	CG14964 / 38384	FlyBaseID:	FBgn0035410	Length:	1443	Species:	Drosophila melanogaster
Sequence 2:	XP_315475.4	Gene:	AgaP_AGAP005471 / 1276165	VectorBaseID:	AGAP005471	Length:	5295	Species:	Anopheles gambiae

Alignment Length:	1661	Identity:	319/1661 - (19%)
Similarity:	530/1661 - (31%)	Gaps:	531/1661 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 PITG----------YTVEHRRMGSPHWVRATPTPVDR-CDVCISGLEPGWRYQF---RC------ 108
            ||.|          :||:...|.:..|::......|| .|..|:.......|..   .|
Mosquito  1729 PIRGLTVEPGENAKFTVQVDEMSNMQWLKDNKPLDDRLADRVITKENDDLTYSLEIQHCREQDSG 1793

  Fly   109 --FAENIVGRSDASELSDPLTVTL---QRNAIT---VPRFIDELVDTNAVEDERIEFRVRILGEP 165
              .|..|.|..:||..:..:..||   ||.|::   .|.|..:|.||..:|...:.|.|::.|:|
Mosquito  1794 IYTARAINGTENASCTAQLIVETLTPEQRKAMSESNSPVFSVQLKDTEVIEKTYLTFMVKVKGDP 1858

  Fly   166 PPEINWFKDGYEIFSSRRTKIVNDNEASV----LVIHQVALTDEGEIKCTATNRAGHVITKARLM 226
            .|::.:.||..||..:.:...:|.:.|.:    |:|.:|...|.|...|||.|:.|...|:|:|:
Mosquito  1859 APKVRFCKDDKEILDTDKRMKINRDRADIGYYELIIPEVHKGDCGVYSCTAWNKFGTTKTEAQLL 1923

  Fly   227 V---------------------------------------------------------------- 227
            |
Mosquito  1924 VADQLDLFSELDNLDDKTKFVWKKNGVAFDPEERFKVLMADDSDSLALVFQHVKPEDAGLYTCVA 1988

  Fly   228 -----------------------QAPPKIRLPRTYEDGLIVEADEVLR-------LKVGVAGQPP 262
                                   |.|.|..|.        ||:.|.|.       |::.|.|.|.
Mosquito  1989 ATSSGNIQCSAELTVQGQVNQLIQEPSKPHLE--------VESREALARIGGKALLEMKVKGYPK 2045

  Fly   263 PAITWLHEGEVIAPGGRFEVSNTEKNSL-LKIDNVLREDRGEYMVKAWNRLGEDSTSFLVTVTAR 326
            |.|.|.|||.:|.||||::....:..|: |.|.:|...|.|.|.:.|.|.|||||| |:..|...
Mosquito  2046 PEIVWRHEGTIIEPGGRYKFLYEDAESVSLVIKDVQPSDAGAYSIVAQNELGEDST-FINLVVKT 2109

  Fly   327 PNPPGTP---------KLNMSFGKSATLSWTAPLDDGGCKI------------------------ 358
            |.....|         :..||...:|..:.|......|.:|
Mosquito  2110 PPTITKPHDMAAMVNEQYKMSIEVNAVPAATVRFFRNGKEIREDDRIKFLTAENYYIIKFNHTVL 2174

  Fly   359 ---GNYIV----------EYFRVGWNVWLKA---ATTRALSTTLHDLIEGSEYKFRVKAE-NPY- 405
               |||.:          |:    |...:.:   .|.|....|:  :.|..:.:..|||| ||.
Mosquito  2175 EDAGNYSIIAMNEISQASEF----WEFTINSPPRTTLRLQEETI--VNEKEDIELVVKAESNPAP 2233

  Fly   406 -------GLSEPSGESELLFIPDPKRGITKPKSATR---------IAGD-----EKDKPKTGAGG 449
                   |....:....::.|.:..|.:.|..:|.|         |..|     ||.:...
Mosquito  2234 IVRWYKDGKEVVADGKRVVIIAEDGRYVLKIHAANRDDTALYTADIINDYGTVTEKSQVNV---- 2294

  Fly   450 MQVPPRRKTLSPPRPQADASTGMSPKQSPSAKRK----PKPQL---IDNEQLTHEMSYGTSDHAL 507
                   .|.|..|.|..|.|....:.....:.|    |:|::   ||:.::|.    ..:::.|
Mosquito  2295 -------STKSKVREQLTALTCKEGETDVMLEVKADGYPRPKVQWYIDDVEITE----SRNEYKL 2348

  Fly   508 KMD-----------------VRKSPSLN--SADSANKPTTDSSNPKLNLTLVTTTLAPLDKSVPS 553
            :.|                 |.|:...|  ..|..:..||...:||:...||.|   .:|::
Mosquito  2349 QEDGLYYQLVLKEVKAEMQGVYKARFTNELGTDETSAMTTVQCSPKVRKPLVDT---DVDEN--- 2407

  Fly   554 PKAPRTPATSPLKLFNPKPSGAPKDRSPVQPKP--------QPLPTPPMETPDKASPNPK----- 605
                 |..|..::::             .:|.|        ||:.|....|..:.|...:
Mosquito  2408 -----TTLTLEVEIY-------------AEPVPEVTWFKNGQPIQTDARLTIKRDSQRVENYTLS 2454

  Fly   606 -----------------RSLSPPNKRQPPPLRKSPTPPEPIKVTPALLRSAEPVQLGVNQNVRRF 653
                             .|:.....:....::|......|:.:....| ..|.|.:.|.:.|.:.
Mosquito  2455 LTMVRGADSGDYEVRAVNSMGTATTKGRVVVQKQADGEPPVVIEEEAL-VTETVAIEVEETVLQV 2518

  Fly   654 SGQ------TLSPAR-----NVPTLALAVASGVSAVIGEKLPTIEISAPPTPQEEEPPVLERSP- 706
            ..|      ...||.     ||.|:.:   |....::.|.:..:.|:||....|:.|..:|..|
Mosquito  2519 QSQEEEEQIVEEPAEEEVQPNVVTVEM---SEEVTLVQEVVSEVTIAAPIAVPEQVPETIEDVPA 2580

  Fly   707 ----SPEP----------APKSQSNARRFSRSADKHDDVHTSNEFMLVVFDKNSKVKDKDKQDSF 757
                :|||          :|...:.|.|......|   :....|.::|.....:.:.::|.....
Mosquito  2581 PVQKAPEPISEQQEAIVASPGENAEAHRMISECMK---IGQHGETIMVSMRATTVIFEEDSGSPI 2642

  Fly   758 ELDLEDAIQPPPISISAPDLAFLEFTNLHTTFP-LRRSVSSTELLYERAMARFYEAVELEQASKS 821
            |: ::..|.|.....||  |...|...:..|.| .:|...|.:...:.|...|.|..|.:..|..
Mosquito  2643 EV-MQKIIYPNKPHASA--LHVEEIDTITFTSPEQKRQYQSQQSASDAATRTFIEEFESDNDSAG 2704

  Fly   822 RKTSRDKLVTPVPHQTPANLRKRLGSISEAERLSFERRSEMRRQSADVVSISRKWDSRENVNEMG 886
            .|....:.|:             :.|.||.|.....|::
Mosquito  2705 GKGKLSRGVS-------------INSASEDELQLLSRQA-------------------------- 2730

  Fly   887 NLTRIHTTGQLPFETRKDLRESEAEEEHEEGEEEHLTESTADDSEDMDLDYDEDLDVDYPPQKKL 951
              :|..:....|.....|..|.|.|...:|..||...|:...:            ||...|:|
Mosquito  2731 --SRTESVPATPTNATLDKSELEKETISQESCEEPKVEAVKVE------------DVPDSPRK-- 2779

  Fly   952 QQQSSNDLGSDYTESTASSEQDSIEK---FKMELLARTRSPSPRDLETYHPRTMGAGTFTPYRAP 1013
                .|.|.|...|..|...  ||||   |:.||                         :|.:..
Mosquito  2780 ----GNLLESGTYEERAGKR--SIEKKVSFEDEL-------------------------SPQQGK 2813

  Fly  1014 TPEQAAVVLNRP-VPLP------------SPDFVPKPILKRSSNEHMEQAVSPLPSSFASEAPTI 1065
            |.|:..|:.|.| .|.|            |...|.:.|:..:..|..|:||....|...:....:
Mosquito  2814 TLERQEVIDNEPEQPEPVKEEVVEKRSASSKALVKETIMDGTVEESAEKAVITEESQEPARPEAV 2878

  Fly  1066 IVPPTATV------ANSNPSTLKMDLAKGIKSFFS--------RDKRSATEKNTEANEEISNPLE 1116
            ...|...:      .:::|..||.|:| .:.:|.|        .|.....|.....|:|:....:
Mosquito  2879 YATPVNRLFAVRYPHSASPEILKTDIA-DVTTFDSLPLIWTVEADGIPRPEVCWYHNDELVKSSD 2942

  Fly  1117 RTNAAAIAADLEVK-RKAKEEE--ELRRKEEERLMQEEAHAAVDHYSDLVKEVGSSHKYHTPLYL 1178
            |..........::: |..||.:  |.:...:.|:.::...|.:        .|....:|..|.::
Mosquito  2943 RIRITDSGTTYKIENRDVKEADAGEWKAVVKNRIGEKSLPAKL--------TVIPCKEYRRPKFM 2999

  Fly  1179 --------DRDELKRAAAKAAAETDEE-DMLTHAEELKKRRATGGSEDLFLAPPVVRERRLSISE 1234
                    .::|....:....::.:.| ..|.:..|:|       ::|..:....::|...::.|
Mosquito  3000 KGLQNISVHKNEPVTLSVTLTSDPEPEITWLQNGNEVK-------ADDYIVLKTEIKELEYNLKE 3057

  Fly  1235 REQLVHVRDAASSLAFHRSPEKPESDQEHESPKSQQDEEPEYPTVLVVPPPKSKNKNESE----T 1295
            ....:|:..|.         .....|...:: |::.|.......:.|:..|:.:|..::.    |
Mosquito  3058 ITYTLHIDQAR---------HYDTGDYTFQA-KNKYDVSESNGRLDVLLKPEIENFRDTTVLPFT 3112

  Fly  1296 ESVMSEMVEARPDARGRTRLVKVKRVIRRRVPSSTRSRDA-SLTR----PAIAEVEGSQQTSLVL 1355
            :.|...:|:|.|.                  |..|.::|. :|..    ..||::|....|.::.
Mosquito  3113 QGVFQVLVKANPK------------------PKVTWTKDGLNLCNNDNCDVIADIEKEVYTLVIE 3159

  Fly  1356 SAADRDLLQKAATLAILQSEEQAHEKVRSALSYCTD 1391
            |.|    |.:..|..:..|..|......:.|:..|:
Mosquito  3160 SCA----LAEHGTYTLTASNAQGETVATANLNVHTE 3191

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14964	NP_647779.2	FN3	29..127	CDD:238020	18/84 (21%)
		I-set	138..227	CDD:254352	30/92 (33%)
		Ig	155..224	CDD:143165	22/72 (31%)
		IG_like	243..323	CDD:214653	35/87 (40%)
		Ig	250..323	CDD:299845	32/80 (40%)
		FN3	327..411	CDD:238020	24/141 (17%)
AgaP_AGAP005471	XP_315475.4	RhoGEF	140..284	CDD:238091
		PH-like	313..409	CDD:302622
		BASP1	1001..1214	CDD:283191
		DUF4775	1100..1451	CDD:292620
		I-set	1724..1814	CDD:254352	18/84 (21%)
		Ig	1752..1811	CDD:143165	12/58 (21%)
		I-set	1831..1924	CDD:254352	30/92 (33%)
		Ig	1848..1921	CDD:143165	22/72 (31%)
		Ig	1942..2000	CDD:143165	0/57 (0%)
		I-set	2017..2107	CDD:254352	36/98 (37%)
		Ig	2036..2107	CDD:299845	31/71 (44%)
		Ig	2110..2194	CDD:299845	11/83 (13%)
		I-set	2110..2192	CDD:254352	11/81 (14%)
		IG	2210..2294	CDD:214652	18/85 (21%)
		Ig	2221..2287	CDD:143165	14/65 (22%)
		I-set	2303..2389	CDD:254352	16/89 (18%)
		Ig	2316..2385	CDD:143165	12/72 (17%)
		I-set	2393..2485	CDD:254352	16/115 (14%)
		Ig	2409..2485	CDD:299845	9/88 (10%)
		Ig	2923..2987	CDD:299845	10/71 (14%)
		I-set	2996..3094	CDD:254352	14/114 (12%)
		Ig	3013..3089	CDD:143165	12/92 (13%)
		I-set	3104..3188	CDD:254352	20/105 (19%)
		Ig	3120..3188	CDD:299845	18/89 (20%)
		I-set	3193..3293	CDD:254352
		Ig	3216..3290	CDD:143165
		I-set	3298..3389	CDD:254352
		Ig	3316..3383	CDD:143165
		I-set	3396..3484	CDD:254352
		IGc2	3410..3476	CDD:197706
		I-set	3493..3582	CDD:254352
		Ig	<3518..3578	CDD:299845
		I-set	3595..3680	CDD:254352
		IGc2	3608..3674	CDD:197706
		I-set	3691..3780	CDD:254352
		Ig	<3716..3780	CDD:299845
		I-set	3793..3882	CDD:254352
		Ig	3810..3880	CDD:143165
		FN3	3906..3999	CDD:238020
		Ig	4065..4129	CDD:299845
		I-set	4141..4231	CDD:254352
		Ig	4159..4231	CDD:299845
		PKc_like	4256..4514	CDD:304357
		S_TKc	4260..4514	CDD:214567
		I-set	4730..4820	CDD:254352
		Ig	4749..4814	CDD:143165
		FN3	4824..4917	CDD:238020
		PKc_like	4970..5229	CDD:304357
		S_TKc	4974..5229	CDD:214567
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0613
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900