DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG14964 and AgaP_AGAP003610

DIOPT Version :9

Sequence 1:NP_647779.2 Gene:CG14964 / 38384 FlyBaseID:FBgn0035410 Length:1443 Species:Drosophila melanogaster
Sequence 2:XP_313369.5 Gene:AgaP_AGAP003610 / 1274273 VectorBaseID:AGAP003610 Length:2338 Species:Anopheles gambiae


Alignment Length:1351 Identity:270/1351 - (19%)
Similarity:444/1351 - (32%) Gaps:453/1351 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   140 FIDELVDTNAVEDERIEFRVRILGEPPPEINWFKDGYEIFSSRRTKIVNDNEASVLVIH--QVAL 202
            |...|.:....|..:::.....:| |.|.|.|||:...:..|:..|  ||.:..|..:|  ...|
Mosquito  1233 FEANLKNQTVAEGSQLKLVCSCVG-PKPTIKWFKNNIPLVWSKNVK--NDTKMGVGAVHILSAEL 1294

  Fly   203 TDEGEIKCTATNRAGHVITKARLMVQ--------APPKIRLPRTYEDGLIVEADEVLRLKVGVAG 259
            .|.|..||||:|..|.|.|..:::|.        ||..:|..:.:.|   ::.:::: |:|.|.|
Mosquito  1295 NDSGTYKCTASNAVGEVETTCKVIVYPVPEKQHVAPSFVRNVKEHYD---IQTNDLV-LEVNVRG 1355

  Fly   260 QPPPAITWLHEG-EVIAPGGRFEVSNTEKNSLLK--IDNVLREDRGEYMVKAWNRLGEDSTSFLV 321
            .|.|.|.||.:| :::.|.|.......|...:.|  |.:...:|.|:|..:|.|.:|:|.....|
Mosquito  1356 NPMPTIKWLRDGIDLVDPTGEKFFPMREPGGVFKLTIHDPQAKDEGQYACEATNVVGKDVLRHAV 1420

  Fly   322 -TVTAR--------------------------PNPPGTPKLNMSFGKSATLSWTAPLDDGGCKIG 359
             .:..|                          |.|...|:.:..|         ..|:||...|.
Mosquito  1421 RRIMERKIAESHVFGIRYHDPNLMKHGVYEEPPKPEPAPRPHREF---------IFLEDGSYYIR 1476

  Fly   360 NYIVEYFRVGWNVWLKAATTRALSTTLHDLIEGSEYKFRVKAE---NPYGLSEPSGESE------ 415
            ....|:      :|.....|.|          .|||:..|..|   .| .:.||..|.|      
Mosquito  1477 GQTPEH------LWEWETDTSA----------PSEYEDYVSPEPEPEP-EVPEPEPEPEPAPVEK 1524

  Fly   416 ----------LLFIPDPKRGITKPKSATRIAGDEKDKPKTGAGGMQVPPRRKTLSPPRPQADAST 470
                      |:..|.|    ..||....:..|::|:.:......:.||      ||        
Mosquito  1525 VPSRSPSPDFLIKTPPP----PPPKQPEPVEADDEDEDEEDEDEEEAPP------PP-------- 1571

  Fly   471 GMSPKQSPS-----AKRKPKPQLIDNEQLTHEMSYGTSDHALKMDVRKSPSLNSADSANKPTTDS 530
               ||:.|.     .||.|:||::..|:                                     
Mosquito  1572 ---PKRGPKIKKLRKKRVPQPQVVPEEE------------------------------------- 1596

  Fly   531 SNPKLNLTLVTTTLAPLDKSVPSPKAPRTPATSPLKLFNPKPSGAPKDRSPVQPKPQPLPTPPME 595
                      ....||   :.|.|:.|:..|..|:::..|......:|:..:: |.:.|...|..
Mosquito  1597 ----------AAIAAP---AAPVPEPPKEVAAPPVEVAAPAEGEPAEDKDKLR-KERYLRLFPEL 1647

  Fly   596 TPDKASPNPKRSLSPPNKRQPPPLRKSPT-------PPEPIKVTPALLRSAEPVQLGVNQNVRRF 653
            .||:|.....|::          ||...|       ..:|:::...:|.|....:...|.....|
Mosquito  1648 NPDEAKRVDARAV----------LRFGSTLHDINIVEGKPVRLFCTVLGSKADFKWYKNGEPMEF 1702

  Fly   654 SGQ--TLSPARNVPTLALAVASGVSAVIGEKLPTIEISAPPTPQEEEPPVLERS----------- 705
            :.|  .||.|:.        .:||.|        ...::.....:.|..|.::|           
Mosquito  1703 TKQIKNLSDAQE--------GTGVIA--------FNKASRDDTADYEVVVKDKSGAVIRGTCRLN 1751

  Fly   706 --PSPEPAPKSQSNARRFSRSADKHDDVHTSN---------------EFML--VVFDKNSK-VKD 750
              |:|...|.::..|.||.|...:|.|:...:               |:.|  ::.:.|.| ::.
Mosquito  1752 VLPAPVRIPVAEGEAPRFVRCMTQHYDLRVDDLVLETQIKGTGPIKVEWFLDGIIIENNEKFIQI 1816

  Fly   751 KDKQDSFELDLEDAIQPPPISISAPDL--AFLEFTNLHTTFPLRRSVSSTELLYERAMARFYEAV 813
            ::.....:|.|.:    |.|..:...|  |..:|......:.||....:.      ||..::   
Mosquito  1817 REPHGIHKLCLHN----PQIRDNGRYLVKASNDFGTEELKYTLRFEGKAA------AMPMYH--- 1868

  Fly   814 ELEQASKSRKTSRDKLVTPVPHQTPANLRKRLGSISEAERLSFERRSEMRRQSADVVSISRKWDS 878
             :..|.|.|....:|:|.|                               ||..:||.:      
Mosquito  1869 -MHHADKRRTFEEEKVVEP-------------------------------RQHREVVFL------ 1895

  Fly   879 RENVNEMGNLTRIHTTGQLP-----FETRKDLRESEAEEEHEEGEEEHLTESTADDSEDMDLDYD 938
                 |.|:   .:..||.|     :||     ::|||.|:    ||::...|:.:.|:.:.:..
Mosquito  1896 -----EDGS---YYLKGQTPERFWEWET-----DTEAESEY----EEYVPGDTSSEEEEAEAEEQ 1943

  Fly   939 EDLDVD----------YPPQKKLQQQSSNDLGSDYTESTASSEQDSIEKFKMELLARTRSPSPRD 993
            .:.:..          .||....|::.:.:         |..|::.:|.....:   .|.|..:.
Mosquito  1944 PEAEEQPATPAKTPQPAPPAAAEQEEEAEE---------AEEEEEEVESPPKPV---KRGPKIKK 1996

  Fly   994 LETYHPRTMGAGTFTPYRAPTPEQAAVVLNRP--VPL---PSPDFVPKPILKRSSNEHMEQAVSP 1053
            |....|           :.|.|||  ||..||  ||.   |.|...||..|            |.
Mosquito  1997 LRRKLP-----------KQPAPEQ--VVEERPKEVPRQREPQPGAQPKVKL------------SQ 2036

  Fly  1054 LPSSFASEAPTIIVPPTATVANSNPSTLKMDLAKGIKSFFSRDKRSATEKNTEANEEISNPLERT 1118
            |.||..|.||    |....|..         ..|.|:..|....||.|.|.       ...|...
Mosquito  2037 LISSGKSLAP----PEVPRVKR---------WKKPIEVEFISHLRSGTIKK-------GKNLTLN 2081

  Fly  1119 NAAAIAADLEVKRKAKEEEELRRKEEERLMQEEAHAAVDHYS----DLVKEVGSSHKYHTPLYLD 1179
            ...:.||.:|| ...|::|.|       :|.....:.|....    |||           .|.|:
Mosquito  2082 CCCSDAAKIEV-TWLKDDEPL-------VMGPRCRSDVTRQGYCTLDLV-----------DLRLE 2127

  Fly  1180 RDELKRAAAKAAAETDEEDMLTHAEELKKRRATGGSEDLFLAPPVVRERRLSISEREQLVHVRDA 1244
            ...:.:..||.|..|..:.......||:|:      :::.|.||..      |:...:|.|    
Mosquito  2128 DTGVYKCVAKTANGTATDSCRITVFELEKK------DEVELVPPTF------ITPLRELYH---- 2176

  Fly  1245 ASSLAFHRSPEKPESDQEHESPKSQQDEEPEYPTVL-VVPPPKSKNKNESETESVMSEMVEARPD 1308
                        |.::..|...:.:.:..|.:..:. .:|..:|..|.|...:...         
Mosquito  2177 ------------PTTNDLHLEIRVRGNPVPTFRWMYDGIPILQSNAKYEIFNQHYY--------- 2220

  Fly  1309 ARGRTRLVKVKRVIRRRVPSSTRSRDAS----LTRPAIAEVEGSQQTSLVL 1355
             ..||::..|:.:|     :..:.||:.    :.|..:..||.|:|.|:.|
Mosquito  2221 -ENRTKITTVQLII-----NDPQLRDSGKYTLIARNDVKSVEMSRQVSIPL 2265

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG14964NP_647779.2 FN3 29..127 CDD:238020
I-set 138..227 CDD:254352 27/88 (31%)
Ig 155..224 CDD:143165 24/70 (34%)
IG_like 243..323 CDD:214653 23/83 (28%)
Ig 250..323 CDD:299845 23/76 (30%)
FN3 327..411 CDD:238020 19/86 (22%)
AgaP_AGAP003610XP_313369.5 I-set 321..409 CDD:254352
Ig 338..401 CDD:143165
Ig <450..510 CDD:299845
I-set 590..673 CDD:254352
Ig 602..668 CDD:143165
Ig 701..769 CDD:143165
Ig 909..995 CDD:299845
I-set 910..995 CDD:254352
I-set 1006..1089 CDD:254352
Ig 1024..1086 CDD:299845
I-set 1232..1319 CDD:254352 27/88 (31%)
IGc2 1244..1309 CDD:197706 22/67 (33%)
Ig 1347..1414 CDD:143165 21/67 (31%)
I-set 1662..1752 CDD:254352 17/105 (16%)
Ig 1670..1742 CDD:299845 15/87 (17%)
Ig 1784..1854 CDD:143165 11/73 (15%)
IG_like 2068..2151 CDD:214653 23/108 (21%)
Ig 2078..2146 CDD:143165 19/86 (22%)
I-set 2165..2263 CDD:254352 22/134 (16%)
Ig 2184..2258 CDD:143165 14/88 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0613
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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