Protein Alignment CG14964 and AgaP_AGAP007556

DIOPT Version :9

• Sequence 1: NP_647779.2
• Gene: CG14964 / 38384
• FlyBaseID: FBgn0035410
• Length: 1443
• Species: Drosophila melanogaster
• Sequence 2: XP_308323.4
• Gene: AgaP_AGAP007556 / 1269678
• VectorBaseID: AGAP007556
• Length: 1262
• Species: Anopheles gambiae
• Alignment Length: 1512
• Identity: 535/1512 - (35%)
• Similarity: 741/1512 - (49%)
• Gaps: 331/1512 - (21%)

  Fly     1 MGNQPGKLHTH-PQGGRPKKNVHWKSAERPSPPGRPILTPVALPEQQPDVVNLRWDRPLHDGGSP 64
            ||||......| ...|:|||.|||||||.|.|||:|.|.| ..|...||||.:||.||..|||||
Mosquito     1 MGNQHSIAIKHGSTAGKPKKAVHWKSAEPPGPPGKPALVP-GSPSSAPDVVTIRWSRPTTDGGSP 64

  Fly    65 ITGYTVEHRRMGSPHWVRATPTPVDRCDVCISGLEPGWRYQFRCFAENIVGRSDASELSDPLTVT 129
            |.||.||.||.||||||||.|:.|.:.::.:||||||||||||..||||||||::||||||||||
Mosquito    65 ILGYVVEQRRTGSPHWVRACPSLVQQTELSLSGLEPGWRYQFRIMAENIVGRSESSELSDPLTVT 129

  Fly   130 LQRNAITVPRFIDELVDTNAVEDERIEFRVRILGEPPPEINWFKDGYEIFSSRRTKIVNDNEASV 194
            ||||||:.|||:.||.|..|||:|::||||.:.|.|.|:|:|||||:||:||||.:|:.:.:.||
Mosquito   130 LQRNAISAPRFVHELFDATAVENEKVEFRVHVAGTPAPQISWFKDGFEIYSSRRARIITEADVSV 194

  Fly   195 LVIHQVALTDEGEIKCTATNRAGHVITKARLMVQAPPKIRLPRTYEDGLIVEADEVLRLKVGVAG 259
            |||||.||||||||||.|||||||.:|:..|.:.|.|||||||.||||||:||:||:|:|||:||
Mosquito   195 LVIHQTALTDEGEIKCAATNRAGHTVTRCHLTIDAYPKIRLPRQYEDGLIIEAEEVVRMKVGLAG 259

  Fly   260 QPPPAITWLHEGEVIAPGGRFEVSNTEKNSLLKIDNVLREDRGEYMVKAWNRLGEDSTSFLVTVT 324
            :||||:.|.|.||.:...||.|:..|:|||.|||.:..|.|||||.::|.|:||||:.|||||||
Mosquito   260 RPPPAVEWAHNGEPLTNDGRHEIVTTDKNSTLKIVSTNRADRGEYHIRALNKLGEDNASFLVTVT 324

  Fly   325 ARPNPPGTPKLNMSFGKSATLSWTAPLDDGGCKIGNYIVEYFRVGWNVWLKAATTRALSTTLHDL 389
            |||.|||...:.:|:||:|||||:||.||||||||||||||.||||:|||||||.|.|:.||.||
Mosquito   325 ARPEPPGRVTVAISYGKTATLSWSAPDDDGGCKIGNYIVEYNRVGWDVWLKAATVRQLTATLSDL 389

  Fly   390 IEGSEYKFRVKAENPYGLSEPSGESELLFIPDPKRGITKPKSATRIAGDEKDKPKTGAGGMQVPP 454
            ||||:|:||||||||||:|:||.|||:||:||||||||   .|:::   :..:|.|      :|.
Mosquito   390 IEGSQYRFRVKAENPYGVSDPSEESEVLFVPDPKRGIT---DASKM---QAQQPST------LPR 442

  Fly   455 RRKTLSPPRPQADASTGMSPKQSPSAKRKPK----PQLIDNEQLTHEMSYGTSDHALKMDVRKSP 515
            :|:.||               |||..:..||    |:......:..||||||
Mosquito   443 KRRDLS---------------QSPMRESLPKKAFTPEPYGRVDVMREMSYGT------------- 479

  Fly   516 SLNSADSANKPTTDSSNPKLNLTLVTTTLAPLDKSV----PSPKAPRTPATSPLKLFNPKPSGAP 576
                                          |||:|:    .:..|| .||.
Mosquito   480 ------------------------------PLDRSIGQGYTNTVAP-VPAL-------------- 499

  Fly   577 KDRSPVQPKPQPLPTPPMETPDKASPNPKRSLSPPNKRQPPPLRKSPTPPEPIKVTPALLRSAEP 641
                 |..:|.||..|..|:......:..|.::|.:.:   .::|....|.|:|::...|.|..
Mosquito   500 -----VVTEPAPLAEPESESESIGPVSNGRGMAPSSLK---AMQKFSKEPSPLKMSDRELSSTG- 555

  Fly   642 VQLGVNQNVRRFSGQTLSPARNVPTLALAVASGVSAVIGEKLPTIEISAPPTPQEEEPPVLERSP 706
                 |.:.:..||                                       .|.|      |.
Mosquito   556 -----NSSDQMGSG---------------------------------------SENE------SS 570

  Fly   707 SPEPAPKSQSNARRFSRSADKHDDVHTSNEFMLVVFDKNSKVKDKDKQDSFELDLEDAI-QPPPI 770
            ..:|:.|:.               :|.|:|||||:::: .:.|...:..:|:.:|::.: .|||:
Mosquito   571 QQQPSSKAA---------------IHNSSEFMLVLYNE-QEAKKSTRNSTFDFELDELVAPPPPL 619

  Fly   771 SISAPDLAFLEFTNLHTTFP---LRRSVSSTELLYERAMARFYEAVELEQASKSRKTSRDKLV-- 830
            |:|||:|      |:... |   :|..||||||||||||||||:||..|::...||.:..:..
Mosquito   620 SLSAPEL------NVEPP-PAPTMRVGVSSTELLYERAMARFYQAVAYEESENQRKEAEQEQAVR 677

  Fly   831 ---TPVPHQTPANLRKRLGSISE---AERLSFERRSEMRRQSADVVSISRKWDSRENVNEMGNLT 889
               .....|.|:...|...|::.   :.||:..|.|..:|.|.|..||.:
Mosquito   678 RRQAAASAQEPSQDDKTGASVTTTTVSNRLADRRSSLRKRLSGDKDSIVK--------------- 727

  Fly   890 RIHTTGQLPFETRKDL---RESEAEEEHEEGEEEHLTESTADDSEDMDLDYDEDLDVDYPPQKKL 951
                  |..||..:.:   .:.:.:..|....||.:.|..:.             .|:...|::|
Mosquito   728 ------QSSFEQDQPIVPPSQQQQQLSHSTLAEETIVEEPSH-------------GVEQQQQQQL 773

  Fly   952 QQQSSNDLG-SDYTESTASSEQDSIEKFKME------------LLARTR---SPSPRDLETYHPR 1000
            :..:|..:| |:..||.:||....||:.|..            :|.:.|   .....|.|.|||.
Mosquito   774 ESFTSLPIGYSEGEESVSSSMNSMIEELKRREQQQKLLEQQVLILPKRRGFMDDDETDEEPYHPG 838

  Fly  1001 TMGAGTFTPYRAPTPEQAAVVLNRPVPLPSPDFVPKPILKRSSNEHMEQAVSPLPSSFASE---- 1061
              |....:|||.|.|.||..||.:|:|||.|:|||||||||.|.|.:.:...|:.|..:|.
Mosquito   839 --GERMRSPYRNPDPSQAIEVLTKPMPLPDPNFVPKPILKRPSTEVLSKGEQPVVSKQSSSNLQL 901

  Fly  1062 APTIIVPPTATVANSNPSTLKMDLAKGIKSFFSRDKRSATEKNTEANEEISNPLERTNAAAIAAD 1126
            :|.  .||.........|.:|:......|......:...:||.....:||...:
Mosquito   902 SPP--QPPKQPTPEREKSPVKVPTPPAKKEEPPEQQMPLSEKQPPKGQEIERAI----------- 953

  Fly  1127 LEVKRKAKEEEELRRKEEERLMQEEAHAAVDHYSDLVKEVGSSHK-YHTPLYLDRDELK----RA 1186
                  ..|....||.|..:...||:.|..|.|||:|:::.||.| ...|||:..||::    |.
Mosquito   954 ------VSEASRQRRLESRQNSIEESRAVADFYSDMVQQIESSKKPRKLPLYMSPDEVRRLNERE 1012

  Fly  1187 AAKAAAETDEEDMLTHAEELKKRRATGGSEDLFLAPPVVRERRLSISEREQLVHVRDAASSLAFH 1251
            .::.::.......|:..:....|..|..|..|....|:|.:|....:...:::..|.|:......
Mosquito  1013 YSRNSSRAGSRSPLSVEDPYLMRGRTSRSPSLASDHPIVVQRGTKPARESKILRQRSASIESETA 1077

  Fly  1252 RSPEKPESDQEHESPKSQQDEEPEYPTVLVVPPPKSKNKNESETESVMSEMVEARPDARGRTRLV 1316
            ..|.....|: ..||...:|:||:..    :..|..|.:......|
Mosquito  1078 SRPPSVVGDR-IGSPVQARDDEPDGR----ISRPLDKKRGTGRAGS------------------- 1118

  Fly  1317 KVKRVIRRRVPSSTRSRDASL-----TRPAIAEVEGSQQTSLVLSAADRDLLQKAATLAILQSEE 1376
                .:|.|..|::.:|.|.:     ..|.:|.|..:......:....|.:..|..|     .|.
Mosquito  1119 ----GVRNRSRSNSAARTAGMQGNTAVAPKVAPVAVAPPPVTAVPPTARVISNKQPT-----PEP 1174

  Fly  1377 QAHEK---------------------VRSALSYCTDLVLFLVACYVYLFKDARLVLPILGLIIYR 1420
            .|..|                     ::..:||.||:.||::||::||||:.:|.:|::.||:||
Mosquito  1175 PARSKPVPETPIEPEPMPPVVPDATELKPTISYLTDVALFVIACWLYLFKNPKLAIPVILLIMYR 1239

  Fly  1421 QLGEAVRGYVPGWLRRR 1437
            .:.|||:..:|.|:||:
Mosquito  1240 HIREAVKDKLPAWMRRK 1256

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14964	NP_647779.2	FN3	29..127	CDD:238020	64/97 (66%)
		I-set	138..227	CDD:254352	56/88 (64%)
		Ig	155..224	CDD:143165	45/68 (66%)
		IG_like	243..323	CDD:214653	46/79 (58%)
		Ig	250..323	CDD:299845	41/72 (57%)
		FN3	327..411	CDD:238020	61/83 (73%)
AgaP_AGAP007556	XP_308323.4	FN3	30..127	CDD:238020	64/97 (66%)
		I-set	138..227	CDD:254352	56/88 (64%)
		Ig	155..217	CDD:143165	41/61 (67%)
		Ig	250..323	CDD:299845	41/72 (57%)
		FN3	327..416	CDD:238020	65/88 (74%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	214	1.000	Domainoid score	I5937
eggNOG	1	0.900	-	-		E1_KOG0613
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	783	1.000	Inparanoid score	I1490
OMA	1	1.010	-	-		QHG27673
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000709
OrthoInspector	1	1.000	-	-		oto107861
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X825
TreeFam	0	0.000	Not matched by this tool.
	9	8.870