DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14964 and SPEG

DIOPT Version :9

Sequence 1:	NP_647779.2	Gene:	CG14964 / 38384	FlyBaseID:	FBgn0035410	Length:	1443	Species:	Drosophila melanogaster
Sequence 2:	XP_011508781.1	Gene:	SPEG / 10290	HGNCID:	16901	Length:	3277	Species:	Homo sapiens

Alignment Length:	1906	Identity:	366/1906 - (19%)
Similarity:	551/1906 - (28%)	Gaps:	762/1906 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 KSAERPSPPGRPIL----------TPVALPEQQPDVVNLRWDRPLHDGGSPITGYTVEHRRMGSP 78
            ||:.:||||..|:.          .|..|  .:||:|                 |.||    |.|
Human  1375 KSSSKPSPPSEPVQLLEHGPTLEEAPAML--DKPDIV-----------------YVVE----GQP 1416

  Fly    79 HWVRATPTPVDRCDVCISGLEPGWRYQFRCFAENIVGRSDASELSDP------------------ 125
            ..|..|...|:...|        ||   .|....:..|:...|||.|
Human  1417 ASVTVTFNHVEAQVV--------WR---SCRGALLEARAGVYELSQPDDDQYCLRICRVSRRDMG 1470

  Fly   126 -LTVT------LQRNAITV-----PRFIDELVDTNAVEDERIEFRVRILGEPPPEINWFKDGYEI 178
             ||.|      .|..::|:     |||...:.|......|...|.|.:.|:|.|:|.|:||  |:
Human  1471 ALTCTARNRHGTQTCSVTLELAEAPRFESIMEDVEVGAGETARFAVVVEGKPLPDIMWYKD--EV 1533

  Fly   179 F---SSRRTKIVNDNEASVLVIHQVALTDEGEIKCTATNRAGHVITKARLMV------------- 227
            .   ||..:.:..:||.| ||:......|.|...|||.|.||.|..||.|.|
Human  1534 LLTESSHVSFVYEENECS-LVVLSTGAQDGGVYTCTAQNLAGEVSCKAELAVHSAQTAMEVEGVG 1597

  Fly   228 -----------------------------------------------QAPPKIR-------LPRT 238
                                                           ||.||..       |.|.
Human  1598 EDEDHRGRRLSDFYDIHQEIGRGAFSYLRRIVERSSGLEFAAKFIPSQAKPKASARREARLLARL 1662

  Fly   239 YED-------------GLIVE----ADEVLRLKVGVAGQPP--------------PAITWLHEGE 272
            ..|             ||::.    .:|:|.   .:|.:|.              ..|.:||:..
Human  1663 QHDCVLYFHEAFERRRGLVIVTELCTEELLE---RIARKPTVCESEIRAYMRQVLEGIHYLHQSH 1724

  Fly   273 VIAPGGRFEVSNTEKNSLLKIDNVLRED--RGEYMVKAWNRLGEDSTSFLVTVTARPNPP----- 330
            |:    ..:|         |.:|:|..|  .||..|    |:.:...:..:|    |..|
Human  1725 VL----HLDV---------KPENLLVWDGAAGEQQV----RICDFGNAQELT----PGEPQYCQY 1768

  Fly   331 GTPK------LNMSFGKSATLSWTAPLDDGGCKIG-----------------NYIVEY------- 365
            |||:      :|.|.....|..|...:....|..|                 ||.|.:
Human  1769 GTPEFVAPEIVNQSPVSGVTDIWPVGVVAFLCLTGISPFVGENDRTTLMNIRNYNVAFEETTFLS 1833

  Fly   366 -FRVGWNVWLKAATTRALSTTLHDLIE---------GSE---------------------YK--- 396
             .|......:|......|..|..:.:|         |:|                     ||
Human  1834 LSREARGFLIKVLVQDRLRPTAEETLEHPWFKTQAKGAEVSTDHLKLFLSRRRWQRSQISYKCHL 1898

  Fly   397 --------FRVKAENPY-----------GLSEPSG--ESELLFIPDPKRGITKPKSATRIA---- 436
                    .|...|..:           |||..|.  |.||..:|...|.:....|.:|::
Human  1899 VLRPIPELLRAPPERVWVTMPRRPPPSGGLSSSSDSEEEELEELPSVPRPLQPEFSGSRVSLTDI 1963

  Fly   437 --GDEK-DKPKTGAG--------GMQVPPRRKTLSP---PRPQADASTGMSPKQ----------- 476
              .||. ..|:|||.        |......::..||   |.|..:.:.|.||::
Human  1964 PTEDEALGTPETGAATPMDWQEQGRAPSQDQEAPSPEALPSPGQEPAAGASPRRGELRRGSSAES 2028

  Fly   477 ----------------------------SPSAKRKPKPQLIDNE------QLTHEMSYGTSDHAL 507
                                        ||.|.|..:..|.:.|      .|...:..|..:..
Human  2029 ALPRAGPRELGRGLHKAASVELPQRRSPSPGATRLARGGLGEGEYAQRLQALRQRLLRGGPEDG- 2092

  Fly   508 KMDVRKSPSLNS----------ADSANKPTTDSSNPKL-NLTLVTTTL----------------A 545
            |:...:.|.|.|          |.:|:........|.| |..|..::.                |
Human  2093 KVSGLRGPLLESLGGRARDPRMARAASSEAAPHHQPPLENRGLQKSSSFSQGEAEPRGRHRRAGA 2157

  Fly   546 PLDKSVPSPKAPR---TPATSPLKLFNPKPSGAPKDRSPVQPK-PQPLPTPPMETPDKASPNPKR 606
            ||:..|....|.|   :|:.|.|....|.....|....|..|| .:|..|.|.:.|...:|.|.:
Human  2158 PLEIPVARLGARRLQESPSLSALSEAQPSSPARPSAPKPSTPKSAEPSATTPSDAPQPPAPQPAQ 2222

  Fly   607 SLSPPNKRQPPPLRKS-PTPPEPIKVTPAL-----LRSAEPVQLGVNQNVRRFSGQTLSPARNVP 665
            ..:|  :.:|.|:|.| |.||.....|.||     .:..:.:||         ||....|::
Human  2223 DKAP--EPRPEPVRASKPAPPPQALQTLALPLTPYAQIIQSLQL---------SGHAQGPSQ--- 2273

  Fly   666 TLALAVASGVSAVIGEKLPTIEI-----SAPP------TPQEEEPPVL---ERSPSPEPAPKS-- 714
                    |.:|...|..|...:     |.||      .|....||||   .|.|:..|.|.|
Human  2274 --------GPAAPPSEPKPHAAVFARVASPPPGAPEKRVPSAGGPPVLAEKARVPTVPPRPGSSL 2330

  Fly   715 -------QSNA---RRFSRSADKHDDVHTSNEFMLVVFDKNSKVKDKDKQDSFELDLEDAIQPP- 768
                   :|.|   .:|.||.:.    ..|....|:     |:.:.:::......:.||.|..|
Human  2331 SSSIENLESEAVFEAKFKRSRES----PLSLGLRLL-----SRSRSEERGPFRGAEEEDGIYRPS 2386

  Fly   769 ----PISI--------SAPDLAFLEFTNLHTTFPLRR-SVSSTELLYERAMARFYEAVELE---- 816
                |:.:        |..||..:....|     :|| |:|.::.|.....|:.:.|.|..
Human  2387 PAGTPLELVRRPERSRSVQDLRAVGEPGL-----VRRLSLSLSQRLRRTPPAQRHPAWEARGGDG 2446

  Fly   817 QASKSRKTSRDKLVTPVPHQTPANLRKRLGSISE--AERLSFERRSE---------------MRR 864
            ::|:...::|.   :||     ..:|:||....|  :.||.....||               :||
Human  2447 ESSEGGSSARG---SPV-----LAMRRRLSFTLERLSSRLQRSGSSEDSGGASGRSTPLFGRLRR 2503

  Fly   865 QSADVVSISR-----------KWDSRENVNEMGNLTRIHTTGQLPFETRKDLRESEAEEEHEEG- 917
            .:::..|:.|           ...:..:...:|:.....:....|.|:|..||...:....::|
Human  2504 ATSEGESLRRLGLPHNQLAAQAGATTPSAESLGSEASATSGSSAPGESRSRLRWGFSRPRKDKGL 2568

  Fly   918 EEEHLTESTADDSEDMDLDYDEDLDVDYPP----------------------------------- 947
            ...:|:.|.   .|::...|... :.|:||
Human  2569 SPPNLSASV---QEELGHQYVRS-ESDFPPVFHIKLKDQVLLEGEAATLLCLPAACPAPHISWMK 2629

  Fly   948 -QKKLQQQSS-------------------------------NDLGSDYTESTAS----------- 969
             :|.|:.:.|                               |.|||..:..|.:
Human  2630 DKKSLRSEPSVIIVSCKDGRQLLSIPRAGKRHAGLYECSATNVLGSITSSCTVAVARVPGKLAPP 2694

  Fly   970 ----SEQD-SIEKFKMELLARTRSPSPRDLE-------TYHPRTMG------------AGTFTPY 1010
                :.|| ::..:|.   ..:|:|....||       .:||.:.|            .|....:
Human  2695 EVPQTYQDTALVLWKP---GDSRAPCTYTLERRVDGESVWHPVSSGIPDCYYNVTHLPVGVTVRF 2756

  Fly  1011 R---------APTPEQAAVVLNRPV----PLPSPDFVPKPILKRSSNEHMEQAVSPLPSSFASEA 1062
            |         .|....:..|..|..    .:||......|:..|.:......:.:.|....|..|
Human  2757 RVACANRAGQGPFSNSSEKVFVRGTQDSSAVPSAAHQEAPVTSRPARARPPDSPTSLAPPLAPAA 2821

  Fly  1063 PTIIVPPTATVANSNPSTLKMDLAKGIKSFFSRDKRSATEKNTEANEEISNPLERTNAAAIAADL 1127
            ||   ||:.||:.|:|.|........:|:.   .....|........:.:.|.|.|..:......
Human  2822 PT---PPSVTVSPSSPPTPPSQALSSLKAV---GPPPQTPPRRHRGLQAARPAEPTLPSTHVTPS 2880

  Fly  1128 EVKRKAKEEEELRRKEEERLMQEEAHAAVDHYSDL-------VKEVGSSHKYHTPLYLDRDELKR 1185
            |.|                      ...:|..:.:       ||.|.||    ||:|:....:..
Human  2881 EPK----------------------PFVLDTGTPIPASTPQGVKPVSSS----TPVYVVTSFVSA 2919

  Fly  1186 --AAAKAAAETDEEDMLTHAEELKKRRATGGSEDLFLAPPVVRERRLSISEREQLVHVRDAASSL 1248
              |....|.|...|......:.|
Human  2920 PPAPEPPAPEPPPEPTKVTVQSL------------------------------------------ 2942

  Fly  1249 AFHRSPEKPESDQEHESPKSQQDEEPEYPTVLVVPPPKSKNKNESETESVMSEMVEARPDARGRT 1313
                ||.|........||:|  ...||..|:...||.|.....|.:.......:...|.:|.|||
Human  2943 ----SPAKEVVSSPGSSPRS--SPRPEGTTLRQGPPQKPYTFLEEKARGRFGVVRACRENATGRT 3001

  Fly  1314 RLVKVKRVIRRRVPSSTRSRDASLTRPAIAEVEGSQQTSLVLSAADRDLLQKAATLAILQSEEQA 1378
            .:.|:       ||.:...:                          |.:||:...|..|.
Human  3002 FVAKI-------VPYAAEGK--------------------------RRVLQEYEVLRTLH----- 3028

  Fly  1379 HEKVRSA-LSYCTDLVLFLVA 1398
            ||::.|. .:|.|...|.|:|
Human  3029 HERIMSLHEAYITPRYLVLIA 3049

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14964	NP_647779.2	FN3	29..127	CDD:238020	27/126 (21%)
		I-set	138..227	CDD:254352	34/91 (37%)
		Ig	155..224	CDD:143165	27/71 (38%)
		IG_like	243..323	CDD:214653	18/99 (18%)
		Ig	250..323	CDD:299845	16/88 (18%)
		FN3	327..411	CDD:238020	28/171 (16%)
SPEG	XP_011508781.1	I-set	43..125	CDD:254352
		Ig	45..125	CDD:299845
		I-set	732..821	CDD:254352
		Ig	755..822	CDD:299845
		SPEG_u2	822..878	CDD:293256
		I-set	879..969	CDD:254352
		IGc2	892..959	CDD:197706
		I-set	983..1068	CDD:254352
		Ig	995..1065	CDD:143165
		I-set	1074..1163	CDD:254352
		Ig	1091..1163	CDD:299845
		I-set	1198..1287	CDD:254352
		Ig	1215..1287	CDD:299845
		I-set	1400..1490	CDD:254352	27/123 (22%)
		I-set	1495..1584	CDD:254352	34/91 (37%)
		Ig	1512..1581	CDD:143165	27/71 (38%)
		STKc_SPEG_rpt1	1608..1864	CDD:271010	46/279 (16%)
		S_TKc	1611..1864	CDD:214567	46/276 (17%)
		I-set	2594..2684	CDD:254352	9/89 (10%)
		Ig	2615..2684	CDD:299845	8/68 (12%)
		STKc_SPEG_rpt2	2972..3228	CDD:271013	24/116 (21%)
		S_TKc	2976..3228	CDD:214567	22/112 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0613
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900