DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG14964 and mylk

DIOPT Version :9

Sequence 1:NP_647779.2 Gene:CG14964 / 38384 FlyBaseID:FBgn0035410 Length:1443 Species:Drosophila melanogaster
Sequence 2:XP_031749515.1 Gene:mylk / 101730432 XenbaseID:XB-GENE-22164540 Length:1969 Species:Xenopus tropicalis


Alignment Length:1590 Identity:307/1590 - (19%)
Similarity:496/1590 - (31%) Gaps:528/1590 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MGNQPG-----KLHTHPQG----------GRPKKNVHWKSAERPSPPGRPILTPVALPEQQPDVV 50
            :|..||     .....|:|          |.|:..|.|.....            ||.|:  |.|
 Frog   252 LGTAPGFDLSPSSQEVPEGSEVIFRCKVSGDPRPRVEWFRENS------------ALGER--DGV 302

  Fly    51 NLRWDRPLHDGGSPITGYTVEHRRMGSPHWVRATPTPVDRCDVCISGLEPGWRYQFRCFAENIVG 115
            .:|                 |..|:.|.|.::|               :.|....:.|...|..|
 Frog   303 RIR-----------------EGARIHSLHLLKA---------------QTGDSGNYSCEVSNARG 335

  Fly   116 RSDASELSDPLTVTLQRNAITVPRFIDELVDTNAVEDERIEFRVRILGEPPPEINWFKDGYEIFS 180
            |...|.   .|:||.::.....|||:.:|...:.:|.|.......|.|:|.|||:|..:...|..
 Frog   336 RVSHSW---TLSVTRRKMEAVAPRFVRKLRGCSIIEGEDFVLECSIEGQPAPEISWLLNDQPIQY 397

  Fly   181 SRRTKIVNDNEASVLVIHQVAL-TDEGEIKCTATNRAGHVITKARLMV---------------QA 229
            :.  ....|..|.:.|  |.|| .|||...|.|.||.|.|...|.:.|               ::
 Frog   398 AH--SAYEDGVARLRV--QDALPEDEGVYTCLAQNRGGKVSCCATVTVTEKKAAEEPGGDREPKS 458

  Fly   230 PPKIRLPRTYEDGLIVEADEVLRLKVGVAGQPPPAITWLHEGEVIAPGGRFEVSNTEKNSLLKID 294
            .|.|.|.| ..|..:::..:| .:.|.::|.||..|.|.|.|:.|.....|....:.....|.|.
 Frog   459 SPPIFLKR-LTDLQVMDGSQV-TMSVELSGTPPAEILWFHNGKEIQETEDFHFEQSGNEHRLCIQ 521

  Fly   295 NVLREDRGEYMVKAWNRLGEDSTSFLVTVT-----ARPNPPGTPK-LNMSFGKSATLS------- 346
            .|..||.|.||.||||.||:.:|...:||.     .:|.....|| .:.|.|::..||       
 Frog   522 EVFPEDTGTYMCKAWNSLGQTATEATLTVQEPQEGIQPWFISKPKCTSASVGQNVILSCAIAGDP 586

  Fly   347 -----W------------------------TAPLDDGG--------------CKIG--------- 359
                 |                        .....|||              |::.         
 Frog   587 FPRVQWLKDGRELPPERILQSDDVFTLILRNVQQSDGGQYQITLINAVGECSCRVSLMVEGSSGG 651

  Fly   360 -------NYIVEYF-----------------RVGW---NVWLKAATTRALSTTLHDLI------- 390
                   :.||.:.                 |.||   :......||......:..::       
 Frog   652 PSHTHQTSLIVSFCLFPNRTLRQREQLRSCERDGWDEEDALSLGRTTEEQQENIRGVLKRRVEVK 716

  Fly   391 EGSEYKFRVKAENPYGLSEPSG---------ESELLFIPDPKRGI-------TKPKSATRIAGDE 439
            |.||.|.|.:...........|         |.:|..||..:...       .|||     |.||
 Frog   717 ESSEEKLRQQEAEQVDFRRVLGKKVSTRSVSEEDLKDIPPEQMDFRANLQRQVKPK-----AEDE 776

  Fly   440 K--DKPKTGAGGMQV---------PPRRKTLSPPRPQADAST----------------GMSPKQS 477
            :  :.|:      ||         |...||..|.:..|.|:|                ..||...
 Frog   777 RKVNSPQ------QVDFRSVLGKKPSTPKTPLPEKVVAKAATPDFRSVLGGKKKLPTENGSPNDV 835

  Fly   478 PSAKRKPKPQ---LIDNEQLTHEMSYGTSDHALKMDVRKSPSLNSADSANKP-TTDSSNPKLNLT 538
            |..:.|.|..   ::|.....:.::..:..:|.|:      |:.|.|.||.| |..:|.|.::.|
 Frog   836 PHEQGKSKVNCCTVVDGGVAKNSVTNNSVPNAAKI------SVLSVDKANVPGTAKNSVPSVDKT 894

  Fly   539 LVTTTLAPLDKSVPSPKAPRTPAT--------SPLKLFNPKPSGAP------------------- 576
            ....|   ...||||......|:|        |.........:|.|                   
 Frog   895 SAPGT---AKNSVPSVDKTSAPSTAKNSVSSGSKASFLGADKAGVPSVAKTSVPTATKTNVPSVD 956

  Fly   577 KDRSPVQPKPQ-------PLPTPP---METPDKAS-----------------------------P 602
            |...|...|..       .|||..   :.:.||||                             |
 Frog   957 KTNVPAATKTNVPSLAKTSLPTATKTNVPSVDKASVPSVDKSSVPAAVKTNDKDVAPSADKQLTP 1021

  Fly   603 NPKRSLSPPNKRQ-PPPLRKSPTPPEPIKVTPALLRSAEPVQLGVNQNVRRFSGQTLSPARN--- 663
            |..:.::|.:::. .|.:.|...|.....|.|::.:...|   .|::::...|.:.::|:.:   
 Frog  1022 NVDKDIAPSSEKDVAPSVDKDVAPSSEKDVAPSVDKDIAP---SVDKDIAPSSDKDVAPSSDKDV 1083

  Fly   664 VPTLALAVASGVSAVIGEKLPTIEISAPPTPQEEEPPVLERSPSP----EPAPKSQSNARRFSRS 724
            .|:....||.|....:.   |:.:....|:.:::..|..|:..:|    :.||.|:.:... |..
 Frog  1084 APSSDKDVAPGSDKDVA---PSSDKDVAPSSEKDVAPSSEKDVAPNSEKDVAPNSEKDVAP-SSE 1144

  Fly   725 ADKHDDVHTSNEFMLVVFDKNSKVKDKDKQDSFELDLEDAIQPPPISISAPDLAFLEFT------ 783
            .|......|..||..|:.|  .:|.|.:|   ..|......:|||..:...|...::.:      
 Frog  1145 KDVAPSAPTKPEFSEVLQD--VRVTDGEK---LVLQCRVTAEPPPTVVWTLDGKVIKSSKYIVLS 1204

  Fly   784 --------NLHTTFPLRRS--VSSTELLYERAMARFYEAVELEQASKS-RKTSRDKLVTPVPHQT 837
                    ::..|||....  :.:.|....||.......||....:|. :|:.:.:...|:.:.|
 Frog  1205 QEGSVCSLSIEKTFPEDEGQYLCAVENAAGRAECACNVTVEDTSGNKGIKKSKKPRSNAPLSNAT 1269

  Fly   838 --PANLRKRLG------SISEAERLSF-ERRSEMRRQSADVV-------SISRKW-DSRENVNEM 885
              .|.::|:..      :.|..:.|.| |.|.....:|.:::       .|:..| ..|:.:.| 
 Frog  1270 ENEATIKKKPAPKTPPKAASAPQILQFPEDRKVKAGESVELLCKVGGTQPITCMWMKFRKEIKE- 1333

  Fly   886 GNLTRIHTTGQLPFETRKDLRESEAEEEH----------EEGEEEHLTESTADDSEDMDLDYDED 940
            ....:|.:|.    ||.| |..|.|.:||          ::|.::.....|..|..|        
 Frog  1334 SEFIKIESTE----ETSK-LTISSARQEHCGCYTLVAENKQGSKQAQVNLTVFDKPD-------- 1385

  Fly   941 LDVDYPPQKKLQQQSSNDLGSDYTESTASSEQDSIEKFKMELLARTRSPSPRDLETYHPRTMGAG 1005
                 ||.               ....||..:.|:                ..|..|.|...|..
 Frog  1386 -----PPA---------------GVPCASCMKGSV----------------LTLSWYGPTYDGGS 1414

  Fly  1006 TFTPYRAPTPEQAAVVLNRPVPLPSPDFVPKPILK--------RSSNEHMEQAVSPLPSSFASEA 1062
            ....|.....:....|........|..|..:.:|:        |::|.|            .:..
 Frog  1415 VVESYSVEIWDSVGKVWTDLTSCRSTSFNVENLLQDREYKFRVRATNIH------------GTSE 1467

  Fly  1063 PTIIVPPTATVANSNPSTLKMDLAKGIKSFFSRDKRSATEKNTEANEEISNPLERTNAAAIAADL 1127
            |:         ..|.|.|.|                   ||..|..||                 
 Frog  1468 PS---------QESEPVTYK-------------------EKEEEHKEE----------------- 1487

  Fly  1128 EVKRKAKEEEELRRKEEERLMQEEAHAAVDHYSDLVKEVGSSHKYHTPLYLDRDELKRAAA---- 1188
              :.:..::||...:.|.|.:...:...|..|.|:.:.:|:. |:.....:...:.::..|    
 Frog  1488 --EAEVSDDEEKESEPEYRDVTLNSSEKVTDYYDVEERLGTG-KFGQVFRIVEKKSRKIYAGKFF 1549

  Fly  1189 KAAAETDEE---------DMLTHAEELKKRRATGGSEDLFLAPPVVR---------ERRLSISER 1235
            ||.:..|:|         :.|.|.:.::...|.....|:.:...:|.         :....::||
 Frog  1550 KAYSAKDKEGIRQEIAIMNCLHHPKLVQCVDAFESKADMVMVLELVSGGELFERIIDEDFELTER 1614

  Fly  1236 EQLVHVRDAASSLAF-HRS-----PEKPES 1259
            |.:.:::.....:.| |:.     ..|||:
 Frog  1615 EVIKYMKQICEGVEFIHKQGIVHLDLKPEN 1644

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG14964NP_647779.2 FN3 29..127 CDD:238020 17/97 (18%)
I-set 138..227 CDD:254352 30/89 (34%)
Ig 155..224 CDD:143165 23/69 (33%)
IG_like 243..323 CDD:214653 26/79 (33%)
Ig 250..323 CDD:299845 26/72 (36%)
FN3 327..411 CDD:238020 24/177 (14%)
mylkXP_031749515.1 Ig 1865..1952 CDD:416386
Ig strand A 1865..1868 CDD:409353
Ig strand A' 1870..1873 CDD:409353
Ig strand B 1877..1886 CDD:409353
Ig strand C 1891..1897 CDD:409353
Ig strand C' 1900..1902 CDD:409353
Ig strand D 1908..1913 CDD:409353
Ig strand E 1916..1924 CDD:409353
Ig strand F 1932..1939 CDD:409353
Ig strand G 1942..1952 CDD:409353
Ig strand A 255..258 CDD:409353 1/2 (50%)
I-set 256..345 CDD:400151 26/137 (19%)
Ig strand A' 261..265 CDD:409353 0/3 (0%)
Ig strand B 273..281 CDD:409353 0/7 (0%)
Ig strand C 286..291 CDD:409353 2/4 (50%)
Ig strand C' 294..296 CDD:409353 0/13 (0%)
Ig strand D 302..307 CDD:409353 2/21 (10%)
Ig strand E 310..315 CDD:409353 1/4 (25%)
Ig strand F 324..332 CDD:409353 1/7 (14%)
Ig 354..441 CDD:416386 30/90 (33%)
Ig strand A 354..357 CDD:409353 1/2 (50%)
Ig strand A' 363..366 CDD:409353 0/2 (0%)
Ig strand B 371..379 CDD:409353 0/7 (0%)
Ig strand C 385..389 CDD:409353 2/3 (67%)
Ig strand C' 392..395 CDD:409353 0/2 (0%)
Ig strand D 399..403 CDD:409353 0/5 (0%)
Ig strand E 407..412 CDD:409353 2/6 (33%)
Ig strand F 420..428 CDD:409353 3/7 (43%)
Ig strand G 431..441 CDD:409353 3/9 (33%)
Ig 461..550 CDD:416386 30/90 (33%)
Ig strand A 461..464 CDD:409353 1/2 (50%)
Ig strand A' 469..472 CDD:409353 1/2 (50%)
Ig strand B 478..485 CDD:409353 2/7 (29%)
Ig strand C 491..496 CDD:409353 2/4 (50%)
Ig strand C' 499..501 CDD:409353 0/1 (0%)
Ig strand D 506..510 CDD:409353 1/3 (33%)
Ig strand E 516..520 CDD:409353 1/3 (33%)
Ig strand F 529..537 CDD:409353 5/7 (71%)
Ig strand G 540..550 CDD:409353 2/9 (22%)
I-set 559..645 CDD:400151 12/85 (14%)
Ig strand A 562..565 CDD:409353 0/2 (0%)
Ig strand A' 567..571 CDD:409353 0/3 (0%)
Ig strand B 574..583 CDD:409353 2/8 (25%)
Ig strand C 589..594 CDD:409353 1/4 (25%)
Ig strand C' 597..600 CDD:409353 0/2 (0%)
Ig strand D 603..608 CDD:409353 0/4 (0%)
Ig strand E 609..617 CDD:409353 0/7 (0%)
Ig strand F 624..632 CDD:409353 1/7 (14%)
Ig strand G 635..645 CDD:409353 1/9 (11%)
MSCRAMM_ClfA <869..1146 CDD:411231 56/292 (19%)
I-set 1155..1244 CDD:400151 18/93 (19%)
Ig strand A' 1160..1164 CDD:409353 2/5 (40%)
Ig strand B 1172..1180 CDD:409353 1/7 (14%)
Ig strand C 1185..1190 CDD:409353 0/4 (0%)
Ig strand C' 1193..1195 CDD:409353 0/1 (0%)
Ig strand D 1201..1206 CDD:409353 0/4 (0%)
Ig strand E 1209..1214 CDD:409353 0/4 (0%)
Ig strand F 1223..1231 CDD:409353 0/7 (0%)
Ig strand G 1234..1244 CDD:409353 2/9 (22%)
Ig 1291..1388 CDD:416386 24/115 (21%)
Ig strand A 1291..1294 CDD:409353 0/2 (0%)
Ig strand A' 1299..1303 CDD:409353 1/3 (33%)
Ig strand B 1307..1316 CDD:409353 1/8 (13%)
Ig strand C 1320..1326 CDD:409353 2/5 (40%)
Ig strand C' 1329..1331 CDD:409353 0/1 (0%)
Ig strand D 1337..1342 CDD:409353 1/4 (25%)
Ig strand E 1346..1351 CDD:409353 2/5 (40%)
Ig strand F 1359..1367 CDD:409353 0/7 (0%)
Ig strand G 1370..1380 CDD:409353 1/9 (11%)
FN3 1384..1476 CDD:238020 21/156 (13%)
PKc_like 1515..1773 CDD:419665 22/131 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 60 1.000 Domainoid score I10423
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
22.000

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