DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14964 and prtg

DIOPT Version :9

Sequence 1:	NP_647779.2	Gene:	CG14964 / 38384	FlyBaseID:	FBgn0035410	Length:	1443	Species:	Drosophila melanogaster
Sequence 2:	XP_004912757.1	Gene:	prtg / 100496178	XenbaseID:	XB-GENE-922463	Length:	1173	Species:	Xenopus tropicalis

Alignment Length:	1198	Identity:	223/1198 - (18%)
Similarity:	373/1198 - (31%)	Gaps:	397/1198 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 ATPTPVDRCDVCISGL---------EPGWRYQFRCFAENIVGRSDASELSDPLTVT--------- 129
            |.|..:||..|...|:         :.|   .:||.|.::..|..::|.  .|||.
Frog   165 ALPLAMDRITVLSKGVLQIYGVTKRDAG---NYRCVATSVSNRRKSTEA--VLTVVPGERLNPRH 224

  Fly   130 -LQRNAITV----------PRFIDELVDTNAVEDERIEFRVRILGEPPPEINWFKDGYEIFSSRR 183
             |.:..:|:          |..|....:......:.:.......|.|.|.::|.:..::......
Frog   225 HLSQTQLTLRAKEKKYFQKPVIIAPPQNITTSMHQSVTLECVATGNPKPIVSWSRRDHKPIDVFN 289

  Fly   184 TKIVNDNEASVLVIHQVALTDEGEIKCTATNRAGHVITKA--RLMVQAPP-------KIRLPRTY 239
            |::|.:..   |:|..|.....|...|.||.......|.|  .:.|.|||       .:.:||..
Frog   290 TRVVGNGN---LIISDVKPHHSGVYICRATTPGTRNFTVAMTTVTVLAPPSFTEWPASLTMPRAS 351

  Fly   240 EDGLIVEADEVLRLKVGVAGQPPPAITWLHEGEVIAPGGRFEVSNTEKNSLLKIDNVLREDRGEY 304
            ....:.:|:          |.|.|.|:||..|:.|...||.::    .||.|.|.:::.||...|
Frog   352 TARFVCQAE----------GNPVPKISWLKNGQKINSNGRIKM----YNSKLVISHIMPEDDAVY 402

  Fly   305 MVKAWNRLGED-STSFLVTV--TARPNPPGTPKLNMSFGKSATLSWTAPLDDGGCKIGNYIVEYF 366
            ...|.|..|.. |.:.|:.|  ..||:.|...:.......:..|||..||.:.. ||..|.|.|.
Frog   403 QCMAENSQGSVLSRARLIVVMYEHRPSAPRQLRAETMSSSAIILSWERPLYNSE-KIIAYSVHYM 466

  Fly   367 RV-GWN-----VWLKAATTRALSTTLHDLIEGSEYKFRVKAENPYGLSEPSGESELLFIPDPKRG 425
            :. |.|     |.:...||..:   :.||...|.:.|.|.|..|.|.|:.|.......:.|
Frog   467 KAEGLNNEEYQVVIGNDTTHYI---IDDLDPASNFTFYVVAYMPMGASQMSDHVTQSTLED---- 524

  Fly   426 ITKPKSATRIAGDEKDKPKTGAGGMQVPPRRKTLS-PPRPQADASTGMSPKQSPSAK-RKPK--- 485
                                      ||.|...:| ..|...|......|   .||| |:.|
Frog   525 --------------------------VPLRAPEISLTSRSPTDVLISWLP---ISAKFRRGKIIH 560

  Fly   486 ---PQLIDNEQLTHEMSYGTSDHALKMDVRKSPSL---------------NSADSANKPTTDSS- 531
               ...:..|..||.:....|.|...::...|.:|               :||.::::....:|
Frog   561 YRLSYRMSTENTTHNVELPGSTHEYFLEGLNSDTLYLVRIAAATKVGWGESSAWTSHRTPKSTSI 625

  Fly   532 ----NPKLNL-TLVTTTLAPLDKSVPSPKA----------------------------------- 556
                :|:|.| .|..||:....:..|...|
Frog   626 RAPRSPELRLDPLNCTTITVRWQQDPDDTATIQGYKLYYKEEGQQESGPVLLDVKDFDYNIGGLD 690

  Fly   557 PRTPATSPLKLFNPKPSGAPKDRSPVQPKPQPLPTPP-METPDKASPNPKRSLSPPNKRQPPPLR 620
            ||......|..:|....|...|        |.:.||. :..||..:|             |||
Frog   691 PRKKYHVRLLAYNNMDEGYQAD--------QTVSTPVCVSAPDHVNP-------------PPP-- 732

  Fly   621 KSPTPPEPIKVTPALLRSAEPVQL-----------GVNQNVRRFSGQTLSPA--RNVPTLALAVA 672
                ||..:.   |...|:..:.|           .:|..||      .:|.  :|. :|.|.:.
Frog   733 ----PPHHLY---AKANSSSSIYLHWGRPAFSSAKAINYTVR------CNPVGLQNA-SLVLYLQ 783

  Fly   673 SGVSAVIGEKLPT-----------IEISAPPTPQEEEPPVLERSPSPEPAPKSQSNARRFSRSAD 726
            :..|.::.:.|..           :::.:.|.     .||:.:|..|:..|:.....:
Frog   784 TTESHILLQDLEANKKYEFAVRLHVDLLSSPW-----SPVVYQSTLPDAPPRPPVGVK------- 836

  Fly   727 KHDDVHTSNEFMLVVFDKNSKVKDKDKQDSFELDLEDAIQPPPISISAPDLAFLEFTNLHTTFP- 790
                        :.:.::|:.:               ....||..:   |.|...:|.|:|:..
Frog   837 ------------VTLIEENTAL---------------VSWKPPEEL---DSAVTSYTILYTSRKS 871

  Fly   791 --------LRRSVSSTELLYERAMARFYEAVELEQASKSRKTSRDKLVTPVPHQTPANLRKRLGS 847
                    :.|..:.|..|.|..:......|::..|:::.:                      |.
Frog   872 WIAGEWQIMHREGTMTMALLENLLPGNIYLVKISAANEAGE----------------------GP 914

  Fly   848 ISEAERLSFERRSEMRRQSADVVSISRKWDS--RENVNEMGNLTRIHTTG--------------- 895
            .|....|..|.:..:|     ||:.|::.||  ||:.:...:|.:...||
Frog   915 FSNVVELVVESKENLR-----VVTRSKQLDSGHREDYSSFYHLDQKSMTGIVVGVCIALTCILIC 974

  Fly   896 QLPFETRKDLRESEAEEEHEEGEEEHLTESTADDSEDMDLDYDEDLDVDYPPQKKLQQQSSNDLG 960
            .|....|...|::...:..:  :|.||
Frog   975 VLILIYRSKARKASIAKTAQ--QEPHL-------------------------------------- 999

  Fly   961 SDYTESTASSEQDSIEKFKMELLARTRSPSPRDLETYHPRTMGAGTFTPYRAPTPEQAAVVLNRP 1025
              ...:|||:..|..|:...:.:..:..|....:|:.|......|            :.:|:|..
Frog  1000 --LPHATASAPTDRQERKATDQVEGSTGPLIPSVESNHFIDAKGG------------SNLVINGY 1050

  Fly  1026 VPLPSPDFVPKPILKRSSNEHMEQAVSPLPSSFASEAP---TIIVPPTATVANSNPSTLKMDLAK 1087
            .|:.:......|..|.:.|..:||....:..:.....|   .:|....:..:..||.|.||
Frog  1051 GPVKNNTKKSWPFFKHNKNGSVEQPNKRIVKAMCLYQPGNRVLIGEDLSPASPGNPGTYKM---- 1111

  Fly  1088 GIKSFFSRDKRSATEK--NTEANEEISN 1113
                   |:..:.||.  |::.:.|.|:
Frog  1112 -------RNSIADTEHSGNSDESHETSD 1132

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14964	NP_647779.2	FN3	29..127	CDD:238020	12/52 (23%)
		I-set	138..227	CDD:254352	17/90 (19%)
		Ig	155..224	CDD:143165	15/70 (21%)
		IG_like	243..323	CDD:214653	23/80 (29%)
		Ig	250..323	CDD:299845	22/73 (30%)
		FN3	327..411	CDD:238020	26/89 (29%)
prtg	XP_004912757.1	Ig	32..121	CDD:386229
		Ig	128..214	CDD:386229	13/53 (25%)
		Ig_3	244..316	CDD:372822	13/74 (18%)
		I-set	336..421	CDD:369462	26/98 (27%)
		FN3	428..521	CDD:238020	27/96 (28%)
		FN3	529..619	CDD:238020	18/92 (20%)
		FN3	628..708	CDD:238020	12/79 (15%)
		FN3	735..823	CDD:238020	15/102 (15%)
		FN3	829..920	CDD:238020	17/149 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0613
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900