DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14964 and igfn1.3

DIOPT Version :9

Sequence 1:	NP_647779.2	Gene:	CG14964 / 38384	FlyBaseID:	FBgn0035410	Length:	1443	Species:	Drosophila melanogaster
Sequence 2:	XP_005168832.1	Gene:	igfn1.3 / 100331959	ZFINID:	ZDB-GENE-131122-44	Length:	1355	Species:	Danio rerio

Alignment Length:	957	Identity:	201/957 - (21%)
Similarity:	303/957 - (31%)	Gaps:	347/957 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PQGGRPKKNVHWKSAERPSPPGR-------PILTPVALPEQQPDVVNLRWDRPLHDGGSPITGY- 68
            |:..:||        .:|.|..:       ||..|.|.|:.:|:|   |.::|..:..:|....
Zfish   486 PEPHKPK--------PKPQPQPQIKQESEGPIEEPEAEPKPEPEV---REEKPKTEEAAPPQAEE 539

  Fly    69 --TVEHRRMGSPHWVRATPTPVDRCDVCISGLEPGWRYQFRCFAENIVGRSDASELSDPLTVTLQ 131
              |.|..|..    ||..|...|      :.::||
Zfish   540 EPTKEEPRKR----VRTGPLVPD------TVIDPG------------------------------ 564

  Fly   132 RNAITVPRFIDELVDTNAVEDERIEFRVRILGEPPPEINWFKDGYEIFSSRRTKIVNDNEASVLV 196
                  ..|...|.|.:|:..:..|...::..|....| |:|||.||.::...|||.|.....:|
Zfish   565 ------VHFTSGLSDVHAIIGQTAEMVCKLSSENCDGI-WYKDGIEITATDDLKIVKDGAVHKIV 622

  Fly   197 IHQVALTDEGEIKCTATNRAGHVITKARLMVQAPPKIRLP--RTYEDGLIVEADEVLRLKVGVAG 259
            :......|.|:.:..|..|.    |:|.|:|:.||:|.|.  ..:.:.:|::..:....|:...|
Zfish   623 VSNCTEDDNGKYRFEADGRK----TEAILVVEDPPRINLEDLAKFSEPVIIKVGQNATFKLEFVG 683

  Fly   260 QPPPAITWLHEGEVIAPGGRFEVSNTEKNSLLKIDNVLREDRGEYMVKAWNRLGE-DSTSFLVTV 323
            :.|..|.|..|||.:......::..:..:|.|.:....|:|.||..:|..|..|. ::.|.|:.:
Zfish   684 REPMKIQWYQEGEEMLEDNHIKIERSSIHSRLLLVKCQRKDSGEIKLKLKNEFGTIEARSKLIVI 748

  Fly   324 TARPNPPGTPKLNMSFGKSATLSWTAPLDDGGCKIGNYIVEYFRVGWNVWLKAAT---------- 378
            ....||.|...:..:........|..|.||||..|.||.:|..::|.|.|:|...
Zfish   749 DKPTNPMGPVDVIEASSSCVEFKWRPPKDDGGSPIINYYLERNQIGRNTWMKIGNIPGEPHYKDN 813

  Fly   379 -----------TRALST------------------------------------------------ 384
                       .|||:.
Zfish   814 DVDHGRKYCYRIRALTAEGTSDVYETSDIQAGTKAYPGQPSTPKVVSAFKNCITLAWTPPTNTGG 878

  Fly   385 ---------------------------------TLHDLIEGSEYKFRVKAENPYGLSEPSGESEL 416
                                             .:.|::||.||:|||.|.|..|..|||..||.
Zfish   879 TNIVGYNMEKRKRGSNLWGQVNPPEEPIKGKQYDVKDVVEGMEYEFRVSAINFSGAGEPSAPSEF 943

  Fly   417 LFIPDPKRGITKPKSATRIAGDEKDKPKTGAGGMQVPPRRKTLSPPRPQADASTGMSPKQSPSAK 481
            :...|||:                                    ||....|.....|...|.|..
Zfish   944 VIARDPKK------------------------------------PPGKVIDLKVTDSTYSSLSLS 972

  Fly   482 -RKPKPQLIDNEQLTHEMSYGTSDHALKMDVRKSPSLNSADSANKPTTDSSNPKLNLTLVTTTLA 545
             .|||.:            .|..|.|....|...|: .|.|...    .:|||     |:|.:..
Zfish   973 WTKPKEE------------KGVQDEAKGYFVELRPA-ESIDWGR----CNSNP-----LITASYT 1015

  Fly   546 PLDKSVPSPKAPRTPATSPLKLFNPKPSGAPKDRS--------PVQP-----KPQPLPTPPMETP 597
            .|.....:....|..||      |....|.|||..        ||:|     |.:.......|..
Zfish  1016 ILGLKSMAMYWVRVVAT------NEGGDGEPKDLDNYIIAMPPPVRPNFTNRKMKSFMVVRAENS 1074

  Fly   598 DKASPNPKRSLSPPNKRQPPPLRKSPTPPEPIKVTPALLRSAEPVQLGVNQNVRRFSGQTLSPAR 662
            .:.:.|               ...||||      |...|:...||...||          :|.|.
Zfish  1075 ARVNIN---------------FEASPTP------TIIWLKDGMPVSKRVN----------ISNAD 1108

  Fly   663 NVPTLALAVA----SGVSAV-----IGEKLPTIEISAPPTPQEEEPPVLER------SPSPEPAP 712
            .:..|.:|.|    ||:.::     :|::..::||.....|:...|..||.      :.|.||:.
Zfish  1109 GMSQLLIASAERSDSGIYSITVKNMVGQETFSVEIRVTDDPKPPGPVELEENVPGTLTVSWEPSS 1173

  Fly   713 -------------KSQSNARRFSRSADK-------HDDVHTSNEFMLVVFDKN----SKVKDK-- 751
                         |..|..|.:...||:       ..::....|:...|:.||    |:..:.
Zfish  1174 DEKRDNHLHYMVMKRDSVKRTWQTVADRLFNNNFTAVNITPGREYKFRVYAKNDIGLSEPSESLK 1238

  Fly   752 ----DKQDSFELDLEDAIQPP--PISI-SAPDLAFLEFT---NLHTT 788
                .|::.|.|:|     ||  |.:. |||:     ||   .:|||
Zfish  1239 WGVVKKREKFILNL-----PPSKPCNFDSAPN-----FTVPLKMHTT 1275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14964	NP_647779.2	FN3	29..127	CDD:238020	21/107 (20%)
		I-set	138..227	CDD:254352	25/88 (28%)
		Ig	155..224	CDD:143165	19/68 (28%)
		IG_like	243..323	CDD:214653	20/80 (25%)
		Ig	250..323	CDD:299845	19/73 (26%)
		FN3	327..411	CDD:238020	32/185 (17%)
igfn1.3	XP_005168832.1	I-set	44..135	CDD:254352
		I-set	326..410	CDD:333254
		I-set	566..638	CDD:333254	20/72 (28%)
		I-set	662..747	CDD:333254	20/84 (24%)
		FN3	751..834	CDD:214495	20/82 (24%)
		FN3	850..944	CDD:238020	16/93 (17%)
		FN3	953..1040	CDD:238020	26/114 (23%)
		Ig	1076..1145	CDD:325142	21/99 (21%)
		FN3	1149..1236	CDD:238020	17/86 (20%)
		I-set	1264..1353	CDD:254352	6/17 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0613
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900