DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14964 and mylk5

DIOPT Version :9

Sequence 1:	NP_647779.2	Gene:	CG14964 / 38384	FlyBaseID:	FBgn0035410	Length:	1443	Species:	Drosophila melanogaster
Sequence 2:	XP_005164113.1	Gene:	mylk5 / 100003770	ZFINID:	ZDB-GENE-050309-74	Length:	856	Species:	Danio rerio

Alignment Length:	473	Identity:	117/473 - (24%)
Similarity:	175/473 - (36%)	Gaps:	107/473 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GNQPGKLHTHPQGGRP--KK--------NVHWKSAERPSPP-------------GRPILTPVALP 43
            |.||     :.||.||  ||        |.::....:..||             |..|....::.
Zfish    20 GFQP-----NGQGSRPVIKKPEDTSSAVNGNYNHTRQLDPPLFTKPLEDCIVDEGNDITLNGSIT 79

  Fly    44 EQQPDVVNLRWDRPLHDGGSPITGYTVEHRRMGSPHWVRATPTPVDRCDVCISGLEPGWRYQFRC 108
            ..||  :::.|   ||:|         |..|.|....|....|.|.|  .|:    |.....:.|
Zfish    80 GSQP--ISISW---LHNG---------ETVRFGKSSLVGEKVTLVVR--ECL----PEDAGAYTC 124

  Fly   109 FAENIVGRSDASELSDPLTVTLQRNAITVPRFIDELVDTNAVEDERIEFRVRILGEPPPEINWFK 173
            .||||.|::.:|             |....|..:.:|..|    ..|..:.......|..:|.
Zfish   125 MAENIAGKTSSS-------------AAVCVRDYESIVRVN----NNIINKSHAHPHTPDLLNG-- 170

  Fly   174 DGYEIFSSRRTKIVNDNEASVL---VIHQVALTDEGEIKCTATNRAGHVITKARLMVQAPPKIRL 235
                  :|..|.:....|:...   |.:...|..|..:|..:::.||..         |||...:
Zfish   171 ------TSEDTSVCKGPESPQTGSPVTNSPVLKREVHVKRRSSSGAGFT---------APPLQFV 220

  Fly   236 PRTYEDGLIVEADEVLRLKVGVAGQPPPAITWLHEGEVIAPGGRFEVSNTEKNSLLKIDNVLRED 300
            ...  |.|.|:..|..||:....|..|.|..|:...:.:....||.:.:.::||.|.|...|.||
Zfish   221 DPL--DRLEVQVGETARLECFFKGSSPVASCWVFNKKEVEESSRFHLESCDENSSLVISEALPED 283

  Fly   301 RGEYMVKAWNRLGEDSTSFLVTVTARPNPPGT-PKLNMSFGKSATLSWTAPLDDGGCKIGNYIVE 364
            .|.|.:...:|......:..:.|...|.||.: |...:....|..|||:.|..|||..:..|:||
Zfish   284 SGRYTIFVRDRKSSAQHTVTLNVIDLPQPPASCPVARVLSPHSLVLSWSGPSYDGGSAVTGYVVE 348

  Fly   365 YFRVGWNVWLKAATTRALSTTLH---DLIEGSEYKFRVKAENPYGLSEPSGESELLFIPDPKRGI 426
            ........| |..|.:..||:|.   .|....:|.||::|.|..|:||||.||:.:.:.:|
Zfish   349 VCEKESEQW-KELTAQCKSTSLRVTSGLQPQGQYCFRIRACNTVGVSEPSQESQTVTMDNP---- 408

  Fly   427 TKPKSATRIAGDEK-DKP 443
                      ||.: :||
Zfish   409 ----------GDSREEKP 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14964	NP_647779.2	FN3	29..127	CDD:238020	26/110 (24%)
		I-set	138..227	CDD:254352	15/91 (16%)
		Ig	155..224	CDD:143165	12/71 (17%)
		IG_like	243..323	CDD:214653	21/79 (27%)
		Ig	250..323	CDD:299845	18/72 (25%)
		FN3	327..411	CDD:238020	30/87 (34%)
mylk5	XP_005164113.1	I-set	55..141	CDD:254352	26/118 (22%)
		Ig	72..137	CDD:143165	23/97 (24%)
		Ig	217..314	CDD:299845	25/98 (26%)
		I-set	218..306	CDD:254352	22/89 (25%)
		FN3	310..404	CDD:238020	34/94 (36%)
		S_TKc	434..689	CDD:214567
		STKc_MLCK	440..689	CDD:271005
		I-set	764..855	CDD:254352
		Ig	781..852	CDD:143165
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0613
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900