DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Asciz and IKZF5

DIOPT Version :9

Sequence 1:	NP_001261357.1	Gene:	Asciz / 38381	FlyBaseID:	FBgn0035407	Length:	388	Species:	Drosophila melanogaster
Sequence 2:	NP_001258769.1	Gene:	IKZF5 / 64376	HGNCID:	14283	Length:	419	Species:	Homo sapiens

Alignment Length:	341	Identity:	76/341 - (22%)
Similarity:	128/341 - (37%)	Gaps:	67/341 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 KCIY-HVATKGARSFTSLRLLRQHYQKSHLDKNYKCLACGGKFLLQHHLEKHQCS-----KHKCP 122
            ||.| :.|:||     :.||: :|.:....:|.::|..|......:.|||.|..|     .:||.
Human    83 KCRYCNYASKG-----TARLI-EHIRIHTGEKPHRCHLCPFASAYERHLEAHMRSHTGEKPYKCE 141

  Fly   123 VCELTYNSKAGLRTHMRRKNHLVHHESDKVPIPSLATWKRLNPQPIPVSADSLTAHSLKTGSDLH 187
            :|....:.::.|..|.|||:.:|..:..:..:.|...|..|..:...:........:|...|.:.
Human   142 LCSFRCSDRSNLSHHRRRKHKMVPIKGTRSSLSSKKMWGVLQKKTSNLGYSRRALINLSPPSMVV 206

  Fly   188 PSEEYINNLPSNLAGVTELYAEIPNPEANMPSTLELDT---NLPAAEEHILCFLPIMDVS-YALE 248
            ...:|:|:...          ||||.:.:...::...|   .||...:.::...|:..:| .|.:
Human   207 QKPDYLNDFTH----------EIPNIQTDSYESMAKTTPTGGLPRDPQELMVDNPLNQLSTLAGQ 261

  Fly   249 MSSQKLDMETQTEEDDLNEIRNEVLAPLLRDIETQTPDTRGDIGTMTDDFPEEQEPVAV---GSH 310
            :||...:.:.....|       .|..|..:....|.|.|:..:..::...|:...|.:.   .||
Human   262 LSSLPPENQNPASPD-------VVPCPDEKPFMIQQPSTQAVVSAVSASIPQSSSPTSPEPRPSH 319

  Fly   311 FHA-YS-----ETEPMFDLQTSAHMYTQTCDDLFEELGLSHIQT-----QTHWPDGLYNTQHTQT 364
            ... ||     .:||      |||..|.:       :|.|...|     ....|..|::.||
Human   320 SQRNYSPVAGPSSEP------SAHTSTPS-------IGNSQPSTPAPALPVQDPQLLHHCQH--- 368

  Fly   365 CDEIMDELFPDNFQST 380
            |    |..|.||...|
Human   369 C----DMYFADNILYT 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asciz	NP_001261357.1	C2H2 Zn finger	98..117	CDD:275368	6/18 (33%)
		zf-C2H2_2	<116..>143	CDD:289522	9/31 (29%)
		C2H2 Zn finger	121..139	CDD:275368	4/17 (24%)
IKZF5	NP_001258769.1	C2H2 Zn finger	84..104	CDD:275368	8/25 (32%)
		zf-H2C2_2	96..121	CDD:404364	6/25 (24%)
		C2H2 Zn finger	112..132	CDD:275368	6/19 (32%)
		zf-H2C2_2	124..148	CDD:404364	8/23 (35%)
		C2H2 Zn finger	140..158	CDD:275368	4/17 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	223..247		3/23 (13%)
		PHA03269	251..>361	CDD:165527	26/129 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	262..356		23/113 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000