DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Asciz and ATMIN

DIOPT Version :9

Sequence 1:	NP_001261357.1	Gene:	Asciz / 38381	FlyBaseID:	FBgn0035407	Length:	388	Species:	Drosophila melanogaster
Sequence 2:	NP_056066.2	Gene:	ATMIN / 23300	HGNCID:	29034	Length:	823	Species:	Homo sapiens

Alignment Length:	443	Identity:	93/443 - (20%)
Similarity:	156/443 - (35%)	Gaps:	119/443 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 VFGNLSHYQLHLRRRHQEVIPPSVIGPIVA---------FHCPVEKCIYHVATKG-ARSFTSLRL 82
            :..|.....:||.:.|:  :...::.|.:.         :.||:|.|     .:| .|.|:...|
Human    94 ILPNSPALNMHLVKSHR--LQDGIVNPTIRKDLKTGPKFYCCPIEGC-----PRGPERPFSQFSL 151

  Fly    83 LRQHYQKSHLDKNYKCLACGGKFLLQHHLEKH--QCSK-HKCPVCELTYNSKAGLRTHMRRKNHL 144
            ::||:.|.|.:|.:||..|...:..:..|::|  .|.| .:| .|...|.|:..|::|:.|..|.
Human   152 VKQHFMKMHAEKKHKCSKCSNSYGTEWDLKRHAEDCGKTFRC-TCGCPYASRTALQSHIYRTGHE 215

  Fly   145 VHHE-----SDKVPIPSLA--------TWKRLNPQPIP-VSADSLTAHSLKTGSDLHPSEEYINN 195
            :..|     |.|..:.:.|        |.:.||.|||| .....|.|..:|    |.||.|  ::
Human   216 IPAEHRDPPSKKRKMENCAQNQKLSNKTIESLNNQPIPRPDTQELEASEIK----LEPSFE--DS 274

  Fly   196 LPSNLAGVT----ELYAE---IPNPEANM-----------------------PSTLELDTNLPAA 230
            ..||....|    ..|.:   :|.|:..:                       |..|.:|......
Human   275 CGSNTDKQTLTTPPRYPQKLLLPKPKVALVKLPVMQFSVMPVFVPTADSSAQPVVLGVDQGSATG 339

  Fly   231 EEHILCFLPIMDVSYALEMSSQKLDMET-------------------------QTEEDDLNEIRN 270
            ..|:   :|:...:..|.:.|:...::.                         ::..:.|.|:.|
Human   340 AVHL---MPLSVGTLILGLDSEACSLKESLPLFKIANPIAGEPISTGVQVNFGKSPSNPLQELGN 401

  Fly   271 EVLAPLLRDIETQTPDTRGDIGTMTDDFPEEQEPVAVGSHFHAYSETEPMFDLQTSAHMYTQTCD 335
            ......:..|..||     |:...:.:|....:.....|...:.|:|:..||.|.|
Human   402 TCQKNSISSINVQT-----DLSYASQNFIPSAQWATADSSVSSCSQTDLSFDSQVS--------- 452

  Fly   336 DLFEELGLSHIQTQTHWPDGLYNTQHTQTCDEIMDELFPDNFQSTCTQTRWLD 388
                 |.:| :.|||..|.....:......|..||..|.....|..|||..::
Human   453 -----LPIS-VHTQTFLPSSKVTSSIAAQTDAFMDTCFQSGGVSRETQTSGIE 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Asciz	NP_001261357.1	C2H2 Zn finger	98..117	CDD:275368	4/20 (20%)
		zf-C2H2_2	<116..>143	CDD:289522	9/27 (33%)
		C2H2 Zn finger	121..139	CDD:275368	6/17 (35%)
ATMIN	NP_056066.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..67
		C2H2 Zn finger	133..160	CDD:275368	11/31 (35%)
		C2H2 Zn finger	167..184	CDD:275368	3/16 (19%)
		C2H2 Zn finger	185..209	CDD:275368	7/24 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	214..234		4/19 (21%)
		Required for formation of RAD51 foci	223..442		39/232 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	268..289		6/22 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	610..634
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	87	1.000	Domainoid score	I8068
eggNOG	1	0.900	-	-		E33208_3BE7S
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	87	1.000	Inparanoid score	I5149
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006179
OrthoInspector	1	1.000	-	-		oto90613
orthoMCL	1	0.900	-	-		OOG6_108086
Panther	1	1.100	-	-	LDO	PTHR46664
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5759
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.890