DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KPNA2 and Kap-alpha3

DIOPT Version :9

Sequence 1:	NP_001307540.1	Gene:	KPNA2 / 3838	HGNCID:	6395	Length:	529	Species:	Homo sapiens
Sequence 2:	NP_001163572.1	Gene:	Kap-alpha3 / 41158	FlyBaseID:	FBgn0027338	Length:	514	Species:	Drosophila melanogaster

Alignment Length:	524	Identity:	261/524 - (49%)
Similarity:	360/524 - (68%)	Gaps:	24/524 - (4%)

- Green bases have known domain annotations that are detailed below.

Human    13 RLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWS 77
            ||..|||||||..||||||.||.|||||.|:::.:||||||.:        |..|.:.:..::.|
  Fly     8 RLQNFKNKGKDQDEMRRRRNEVTVELRKNKREETILKRRNVPN--------LDSNTDEEEQLSSS 64

Human    78 VD--DIVK-GINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFE 139
            :|  .:.| ..:::..|.||.|.||||||||.:|.|||:::|::.::|..|..|.:.:.:.:|||
  Fly    65 IDLKKLAKAAADATKPEQQLAAVQAARKLLSSDKNPPINDLIQSDILPILVECLKQHNHTMLQFE 129

Human   140 SAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYG 204
            :||||||||||||.||..||..||:|.|:.||.||..::.||||||||||.|||.:.||.|||:|
  Fly   130 AAWALTNIASGTSAQTNEVVAAGAVPLFLQLLNSPAPNVCEQAVWALGNIIGDGPLLRDFVIKHG 194

Human   205 AVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLA 269
            .|.|||:.:. ||   :...:|||:||.:.||||||:||||...:.:|||.|..|:||.|..:|.
  Fly   195 VVQPLLSFIK-PD---IPITFLRNVTWVIVNLCRNKDPAPPTATIHEILPALNVLIHHTDTNILV 255

Human   270 DTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDA 334
            ||.|||||||||.|::|.||:::||||:|:.|||.||:.:.|.||||:||||||:|||||||::.
  Fly   256 DTVWAISYLTDGGNDQIQMVIESGVVPKLIPLLGNSEVKVQTAALRAVGNIVTGSDEQTQVVLNY 320

Human   335 GALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVW 399
            .||:.||.||::||..|:|||.|.:||||||.|.|:|.|:|.||:|.::..|||.:|:|||||.|
  Fly   321 DALSYFPGLLSHPKEKIRKEAVWFLSNITAGNQSQVQAVINVGLLPKIIENLSKGEFQTQKEAAW 385

Human   400 AVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMI 464
            |::|.|..|..||:..|:..|:|.|..:||:.:||::|.|:||.::|:.:.|:  ...|.::..|
  Fly   386 AISNLTISGNREQVFTLIKEGVIPPFCDLLSCQDTQVINVVLDGLNNMLKVAD--SHVEAVANCI 448

Human   465 EECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAP----G 525
            |||.||.|||.||:|||..:||.:..:|::||: :|.|..|:.|  ||:|..:.....|.    .
  Fly   449 EECEGLAKIERLQSHENVEIYKLAYEIIDQYFT-DEGEQTNMAP--TSDGAQYNFDPHADRLTMN 510

Human   526 TFNF 529
            :|||
  Fly   511 SFNF 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KPNA2	NP_001307540.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27		9/13 (69%)
		SRP1	10..528	CDD:227396	258/521 (50%)
		IBB	10..98	CDD:280005	38/87 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..72		8/28 (29%)
		Nuclear localization signal. /evidence=ECO:0000250	45..54		5/8 (63%)
		ARM 1, truncated	71..111		16/42 (38%)
		ARM 2	112..151		17/38 (45%)
		ARM	113..238	CDD:237987	63/124 (51%)
		armadillo repeat	115..147	CDD:293788	12/31 (39%)
		NLS binding site (major). /evidence=ECO:0000250	142..238		55/95 (58%)
		armadillo repeat	155..191	CDD:293788	21/35 (60%)
		armadillo repeat	197..236	CDD:293788	17/38 (45%)
		ARM 4	200..244		22/43 (51%)
		ARM 5	246..282		19/35 (54%)
		ARM	252..364	CDD:237987	68/111 (61%)
		armadillo repeat	253..278	CDD:293788	14/24 (58%)
		ARM 6	283..322		22/38 (58%)
		armadillo repeat	286..322	CDD:293788	21/35 (60%)
		NLS binding site (minor). /evidence=ECO:0000250	315..403		53/87 (61%)
		armadillo repeat	328..362	CDD:293788	18/33 (55%)
		ARM	329..449	CDD:237987	59/119 (50%)
		ARM 8	367..409		21/41 (51%)
		armadillo repeat	370..404	CDD:293788	17/33 (52%)
		ARM 9	410..456		16/45 (36%)
		armadillo repeat	413..447	CDD:293788	12/33 (36%)
		ARM 10, atypical	457..496		18/38 (47%)
		Arm_3	458..508	CDD:292804	23/49 (47%)
		armadillo repeat	460..495	CDD:293788	17/34 (50%)
Kap-alpha3	NP_001163572.1	IBB	7..88	CDD:280005	38/87 (44%)
		SRP1	8..500	CDD:227396	257/508 (51%)
		ARM	104..224	CDD:237987	63/123 (51%)
		armadillo repeat	104..137	CDD:293788	12/32 (38%)
		armadillo repeat	145..181	CDD:293788	21/35 (60%)
		armadillo repeat	187..222	CDD:293788	17/38 (45%)
		ARM	236..350	CDD:237987	68/113 (60%)
		armadillo repeat	239..264	CDD:293788	14/24 (58%)
		armadillo repeat	272..308	CDD:293788	21/35 (60%)
		armadillo repeat	314..348	CDD:293788	18/33 (55%)
		ARM	315..433	CDD:237987	58/117 (50%)
		armadillo repeat	356..390	CDD:293788	17/33 (52%)
		armadillo repeat	399..433	CDD:293788	12/33 (36%)
		Arm_3	442..485	CDD:292804	21/43 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5064
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54553
OrthoDB	1	1.010	-	-		D1111872at2759
OrthoFinder	1	1.000	-	-		FOG0000157
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.830