Protein Alignment KPNA2 and Kap-alpha1

DIOPT Version :10

• Sequence 1: NP_002257.1
• Gene: KPNA2 / 3838
• HGNCID: 6395
• Length: 529
• Species: Homo sapiens
• Sequence 2: NP_524167.1
• Gene: Kap-alpha1 / 40160
• FlyBaseID: FBgn0024889
• Length: 543
• Species: Drosophila melanogaster
• Alignment Length: 552
• Identity: 251/552 - (45%)
• Similarity: 345/552 - (62%)
• Gaps: 44/552 - (7%)

Human    11 AARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSP----LQENRNNQ 71
            |:...|:||...|||||||||.||.::|||.|::.|:.|||||...|  |||.    ::.|.:|:
  Fly     3 ASHKQRYKNAALDSTEMRRRREEVGIQLRKNKREQQLFKRRNVVLEP--ATSSTSAGVESNTDNE 65

Human    72 ---------------------------GTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQ 109
                                       ..:|   :::::.:.|.....||:|||..||||||:..
  Fly    66 QQAADMHMADSSTGGQNEEAAGSGAQPSVIN---EEMIQMLFSGRENEQLEATQKFRKLLSRDPN 127

Human   110 PPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASP 174
            |||:.:|:.|::|:||:||..:..:.:|||:||.|||||||||:|||.|::.||:|.||.||:||
  Fly   128 PPIEEVIQKGIVPQFVTFLRNSANATLQFEAAWTLTNIASGTSQQTKVVIEAGAVPIFIDLLSSP 192

Human   175 HAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRN 239
            |..:.|||||||||||||..:.||.::..|.::|||.:|:..|..::    :||..||||||||.
  Fly   193 HDDVQEQAVWALGNIAGDSPMCRDHLLGSGILEPLLHVLSNSDRITM----IRNAVWTLSNLCRG 253

Human   240 KNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGA 304
            |:|......:...||.|.|||.:.|.:||:||||||.||:||||::|..|:..||..:||:||..
  Fly   254 KSPPADFAKISHGLPILARLLKYTDADVLSDTCWAIGYLSDGPNDKIQAVIDAGVCRRLVELLLH 318

Human   305 SELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQ 369
            .:..:.|.||||:||||||.|:||||::...||.....||.:....|:||:.||:|||.||.::|
  Fly   319 PQQNVSTAALRAVGNIVTGDDQQTQVILGYNALTCISHLLHSTAETIKKESCWTISNIAAGNREQ 383

Human   370 IQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDT 434
            ||.::|..:.|.|:.::..|:|||:|||.||:||.||.||.|||.|||..|.:.|:.:.||..|:
  Fly   384 IQALINANIFPQLMVIMQTAEFKTRKEAAWAITNATSSGTHEQIHYLVQVGCVPPMCDFLTVVDS 448

Human   435 KIILVILDAISNIFQAAEKL-GETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSV 498
            .|:.|.|:|:.||.:|.||. ......:|.|||||||||||.||.|||..:|..|..:||:||.
  Fly   449 DIVQVALNALENILKAGEKFQTRPNPYAITIEECGGLDKIEYLQAHENRDIYHKSFYIIEQYFG- 512

Human   499 EEEEDQNVVPETTSEGYTFQVQDGAPGT-FNF 529
            .||||..|.|...::.:.|. .|..|.| |||
  Fly   513 NEEEDSRVAPVAGTQQFEFD-PDNMPSTGFNF 543

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KPNA2	NP_002257.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27		7/15 (47%)
		SRP1	10..528	CDD:227396	248/549 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	43..72		12/59 (20%)
		Nuclear localization signal. /evidence=ECO:0000250	45..54		5/8 (63%)
		ARM 1, truncated	71..111		13/66 (20%)
		ARM 2	112..151		19/38 (50%)
		armadillo repeat	115..147	CDD:293788	14/31 (45%)
		NLS binding site (major). /evidence=ECO:0000250	142..238		53/95 (56%)
		armadillo repeat	155..191	CDD:293788	23/35 (66%)
		armadillo repeat	197..236	CDD:293788	14/38 (37%)
		ARM 4	200..244		18/43 (42%)
		ARM 5	246..282		18/35 (51%)
		armadillo repeat	253..278	CDD:293788	15/24 (63%)
		ARM 6	283..322		17/38 (45%)
		armadillo repeat	286..322	CDD:293788	16/35 (46%)
		NLS binding site (minor). /evidence=ECO:0000250	315..403		42/87 (48%)
		armadillo repeat	328..362	CDD:293788	13/33 (39%)
		ARM 8	367..409		19/41 (46%)
		armadillo repeat	370..404	CDD:293788	15/33 (45%)
		ARM 9	410..456		20/46 (43%)
		armadillo repeat	413..447	CDD:293788	13/33 (39%)
		ARM 10, atypical	457..496		21/38 (55%)
		armadillo repeat	460..495	CDD:293788	21/34 (62%)
Kap-alpha1	NP_524167.1	SRP1	1..543	CDD:227396	249/550 (45%)
		armadillo repeat	133..165	CDD:293788	14/31 (45%)
		armadillo repeat	173..209	CDD:293788	23/35 (66%)
		armadillo repeat	215..250	CDD:293788	14/38 (37%)
		armadillo repeat	267..292	CDD:293788	15/24 (63%)
		armadillo repeat	300..336	CDD:293788	16/35 (46%)
		armadillo repeat	342..376	CDD:293788	13/33 (39%)
		armadillo repeat	384..421	CDD:293788	17/36 (47%)
		armadillo repeat	427..461	CDD:293788	13/33 (39%)