Protein Alignment KPNA2 and alphaKap4

DIOPT Version :10

• Sequence 1: NP_002257.1
• Gene: KPNA2 / 3838
• HGNCID: 6395
• Length: 529
• Species: Homo sapiens
• Sequence 2: NP_648007.1
• Gene: alphaKap4 / 38675
• FlyBaseID: FBgn0035657
• Length: 442
• Species: Drosophila melanogaster
• Alignment Length: 486
• Identity: 129/486 - (26%)
• Similarity: 225/486 - (46%)
• Gaps: 59/486 - (12%)

Human    13 RLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWS 77
            |..||..||::...:|..|:|      ||||
  Fly     4 RKRRFLKKGQNLMMLRTLRLE------KAKK---------------------------------- 28

Human    78 VDDIVKGINSSNVENQLQATQAAR--KLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFES 140
                      :.::.:|....|..  ||.|.|..|.::.::::..|...|..||..:.:.|:.::
  Fly    29 ----------AELQKELTIYNALTKCKLTSSEVVPDVNKLLKSNTIGNLVESLGHGNKNKIRADA 83

Human   141 AWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGA 205
            |.||.:||||:||.:..:...||:|..|.||.||...:.|:.:.:|||:.......||.:|::|.
  Fly    84 ADALAHIASGSSEHSNLIAKAGAVPRLIRLLQSPDPEVCEKGILSLGNLLHFAPNLRDYIIRHGL 148

Human   206 VDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLAD 270
            :..|:::  :.|.|:... .|.::||.|..||.:..|:||.:|.| |:..|..:|::.:..||.|
  Fly   149 MQKLMSI--IQDKSTCTL-MLSHVTWVLRKLCISSQPSPPDNAAE-IIQALNIVLYNPEANVLED 209

Human   271 TCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAG 335
            ...|:..|..| ||.|.|::...|||:::.||....:.:...||:|:.||.||::||.|.:::..
  Fly   210 ALMAVRNLAHG-NETIQMLLDFEVVPRIIYLLEHPNVTVQNAALQALINIATGSEEQIQELLNNN 273

Human   336 ALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWA 400
            .|....:|::|...:|:.:....:.||..|...|...::|.||:..::..|.......:..|...
  Fly   274 LLPHLSALMSNSDPDIRCQVLKLLLNIADGNIFQRHAIMNAGLLHKILECLKADAISLKSAAALT 338

Human   401 VTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIE 465
            :|..........:.||:..|:|....|||..::..|:..:||.:|.:.......  :.::|.:||
  Fly   339 ITTLAIDKDKNLLCYLMRQGVIPEFCNLLFCQERDILSNVLDILSTMLDVDPSF--SAEVSGIIE 401

Human   466 ECGGLDKIEALQNHENESVYKASLSLIEKYF 496
            ..|.|:.|..||:.|:|.:...:..:|..||
  Fly   402 WSGALNNIRMLQSSEHEEIAAVARKIIGNYF 432

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KPNA2	NP_002257.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27		5/13 (38%)
		SRP1	10..528	CDD:227396	129/486 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	43..72		1/28 (4%)
		Nuclear localization signal. /evidence=ECO:0000250	45..54		0/8 (0%)
		ARM 1, truncated	71..111		6/41 (15%)
		ARM 2	112..151		11/38 (29%)
		armadillo repeat	115..147	CDD:293788	8/31 (26%)
		NLS binding site (major). /evidence=ECO:0000250	142..238		32/95 (34%)
		armadillo repeat	155..191	CDD:293788	12/35 (34%)
		armadillo repeat	197..236	CDD:293788	11/38 (29%)
		ARM 4	200..244		12/43 (28%)
		ARM 5	246..282		10/35 (29%)
		armadillo repeat	253..278	CDD:293788	6/24 (25%)
		ARM 6	283..322		14/38 (37%)
		armadillo repeat	286..322	CDD:293788	12/35 (34%)
		NLS binding site (minor). /evidence=ECO:0000250	315..403		21/87 (24%)
		armadillo repeat	328..362	CDD:293788	5/33 (15%)
		ARM 8	367..409		7/41 (17%)
		armadillo repeat	370..404	CDD:293788	6/33 (18%)
		ARM 9	410..456		11/45 (24%)
		armadillo repeat	413..447	CDD:293788	11/33 (33%)
		ARM 10, atypical	457..496		11/38 (29%)
		armadillo repeat	460..495	CDD:293788	11/34 (32%)
alphaKap4	NP_648007.1	SRP1	45..432	CDD:227396	113/393 (29%)
		armadillo repeat	98..134	CDD:293788	12/35 (34%)
		armadillo repeat	140..176	CDD:293788	11/38 (29%)
		armadillo repeat	192..217	CDD:293788	6/24 (25%)
		armadillo repeat	224..260	CDD:293788	12/35 (34%)
		armadillo repeat	266..300	CDD:293788	5/33 (15%)
		armadillo repeat	308..342	CDD:293788	6/33 (18%)
		armadillo repeat	350..383	CDD:293788	10/32 (31%)